The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Phospholipid biosynthesis in mammalian cells
Abstract
Identification of the genes and gene products involved in the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine has lagged behind that in many other fields because of difficulties encountered in purifying the respective proteins. Nevertheless, most of these genes have now been identified. In this review article, we have highlighted important new findings on the individual enzymes and the corresponding genes of phosphatidylcholine synthesis via its two major biosynthetic pathways: the CDP-choline pathway and the methylation pathway. We also review recent studies on phosphatidylethanolamine biosynthesis by two pathways: the CDP-ethanolamine pathway, which is active in the endoplasmic reticulum, and the phosphatidylserine decarboxylase pathway, which operates in mitochondria. Finally, the two base-exchange enzymes, phosphatidylserine synthase-1 and phosphatidylserine synthase-2, that synthesize phosphatidylserine in mammalian cells are also discussed.Key words: phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, biosynthesis.
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Cites
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses
Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257
The SREBP Pathway in Drosophila
Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00119-8 · Cited by 194
Cited by
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
Meikle, P. J., & Summers, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.169 · Cited by 423
Phosphatidylserine in the brain: Metabolism and function
Kim, H.-Y., Huang, B. X., & Spector, A. A. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.06.002 · Cited by 389
The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria
Fujimoto, M., Hayashi, T., & Su, T.-P. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.022 · Cited by 140
van Wijk, N., Broersen, L. M., de Wilde, M. C., Hageman, R. J. J., Groenendijk, M., Sijben, J. W. C., & Kamphuis, P. J. G. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130998 · Cited by 128
Phosphatidic acid: an emerging versatile class of cellular mediators
Kim, S.-C., & Wang, X. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190089 · Cited by 94
Metadata
- Authors
- Vance, J. E., & Vance, D. E.
- Venue
- Biochemistry and Cell Biology
- Publisher
- Canadian Science Publishing
- Published
- 2004-02-01
- Volume
- 82
- Issue
- 1
- Pages
- 113-128
- ISSN
- 0829-8211 (ISSN-L)
- 1208-6002
- OpenAlex
- W2053433344
- Cited by
- 373
- References
- 2
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vance, J. E., & Vance, D. E. (2004). Phospholipid biosynthesis in mammalian cells. Biochemistry and Cell Biology. https://doi.org/10.1139/o03-073
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