Cited by 128Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchFatty Acid Research and Health

Targeting Synaptic Dysfunction in Alzheimer’s Disease by Administering a Specific Nutrient Combination

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van Wijk, Nick, Broersen, Laus M., de Wilde, Martijn C., Hageman, Robert J.J., Groenendijk, Martine, Sijben, John W.C., Kamphuis, Patrick J.G.H.·2013·Journal of Alzheimer s Disease

Abstract

Synapse loss and synaptic dysfunction are pathological processes already involved in the early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal membranes, and the neuronal and synaptic losses observed in AD have been linked to the degeneration and altered composition and structure of these membranes. Consequently, synapse loss and membrane-related pathology provide viable targets for intervention in AD. The specific nutrient combination Fortasyn Connect (FC) is designed to ameliorate synapse loss and synaptic dysfunction in AD by addressing distinct nutritional needs believed to be present in these patients. This nutrient combination comprises uridine, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium, and is present in Souvenaid, a medical food intended for use in early AD. It has been hypothesized that FC counteracts synaptic loss and reduces membrane-related pathology in AD by providing nutritional precursors and cofactors that act together to support neuronal membrane formation and function. Preclinical studies formed the basis of this hypothesis which is being validated in a broad clinical study program investigating the potential of this nutrient combination in AD. Memory dysfunction is one key early manifestation in AD and is associated with synapse loss. The clinical studies to date show that the FC-containing medical food improves memory function and preserves functional brain network organization in mild AD compared with controls, supporting the hypothesis that this intervention counteracts synaptic dysfunction. This review provides a comprehensive overview of basic scientific studies that led to the creation of FC and of its effects in various preclinical models.

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Crossref · 10.3233/jad-130998

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  • Research shows a positive correlation between increased physical activity, cognitive training, improved nutrition, and slowing cognitive and functional decline and intensity of BPSD.

    “Indeed, research shows a positive correlation between increased physical activity, cognitive training, improved nutrition, and slowing cognitive and functional decline and intensity of BPSD.”

    From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [171]

    The 'Clinical Utility of the Specific Nutrient Combination in AD' section reports improved memory after a specific nutritional intervention in patients with mild Alzheimer’s disease. It does not establish that physical activity or cognitive training slows decline, or that these approaches reduce functional decline or the intensity of behavioral and psychological symptoms of dementia (BPSD). The reported result is an intervention effect, not the broad correlation claimed. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Preclinical studies showed that administration of specific combinations of phospholipid synthesis-promoting nutrients can enhance neurotransmission and cognitive function.

    “Preclinical studies showed that administration of specific combinations of the phospholipid synthesis-promoting nutrients can enhance neurotransmission and cognitive function [159].”

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Authors
van Wijk, N., Broersen, L. M., de Wilde, M. C., Hageman, R. J. J., Groenendijk, M., Sijben, J. W. C., & Kamphuis, P. J. G. H.
Affiliations
  • Nutricia Advanced Medical Nutrition, Nutricia Research, Utrecht, The Netherlands
  • Nutricia Research (Netherlands) (NL)
  • Utrecht University (NL)
Venue
Journal of Alzheimer s Disease
Published
2013-11-25
Volume
38
Issue
3
Pages
459-479
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1504296704
Cited by
128
References
169
Citations by year
2026: 3 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 9 · 2017: 17 · 2016: 15 · 2015: 11 · 2014: 5 · 2013: 2
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
Alzheimer's disease, synaptic dysfunction
MeSH terms
Alzheimer Disease, Animals, Brain, Humans, Nutritional Status, Synapses, Dietary Supplements

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