The SREBP Pathway in Drosophila
Open accessAbstract
In mammals, synthesis of cholesterol and unsaturated fatty acids is controlled by SREBPs, a family of membrane-bound transcription factors. Here, we show that the Drosophila genome encodes all components of the SREBP pathway, including a single SREBP (dSREBP), SREBP cleavage-activating protein (dSCAP), and the two proteases that process SREBP at sites 1 and 2 to release the nuclear fragment. In cultured Drosophila S2 cells, dSREBP is processed at sites 1 and 2, and the liberated fragment increases mRNAs encoding enzymes of fatty acid biosynthesis, but not sterol or isoprenoid biosynthesis. Processing requires dSCAP, but is not inhibited by sterols as in mammals. Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Homologs of SREBPs do not respond to changes in cholesterol, but rather changes in palmitate and/or phospholipids.
“It has been previously shown that the homologs of SREBPs do not respond to changes in cholesterol, but rather changes in palmitate and/or phospholipids (39,40).”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [40]
The Results report that palmitate reduced nuclear dSREBP in Drosophila S2 cells, whereas a cholesterol-containing sterol mixture failed to do so. The Discussion proposes that palmitic acid or a lipid derived from it regulates this pathway, but does not establish phospholipids as the signal. The claim also generalizes beyond the Drosophila homolog studied here. (LLM, conf=0.86)
Experimental — accuracy not yet measuredD. melanogaster is a cholesterol auxotroph and activation of SREBP is regulated by reduced levels of palmitate and/or phospholipids.
“D. melanogaster is a cholesterol auxotroph and activation of SREBP is regulated by reduced levels of palmitate and/or phospholipids.”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [40]
The paper says insects require dietary sterols, supporting the description of D. melanogaster as a cholesterol auxotroph. The Results and Discussion show that added palmitate inhibits dSREBP processing in cultured Drosophila cells, but the Discussion says it is not clear whether palmitate itself or a more complex lipid, possibly a phospholipid, is responsible. It does not establish that reduced phospholipid levels activate SREBP. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
A simple method for displaying the hydropathic character of a protein
Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,694 · see citing works
Real time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180 · see citing works
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works
Self-citationRegulated Intramembrane Proteolysis
Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80675-3 · Cited by 1,329 · see citing works
Self-citationA proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11041 · Cited by 1,327 · see citing works
Self-citationCell lines derived from late embryonic stages of Drosophila melanogaster
Schneider, I. (1972) · Development · doi:10.1242/dev.27.2.353 · Cited by 1,219 · see citing works
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Preprint
Kim, J. B., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.9.1096 · Cited by 1,026 · see citing works
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
Wang, X., Sato, R., Brown, M. S., Hua, X., & Goldstein, J. L. (1994) · Cell · doi:10.1016/0092-8674(94)90234-8 · Cited by 1,003 · see citing works
Self-citationYokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 968 · see citing works
Self-citationClemens, J. C., Worby, C. A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B. A., & Dixon, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110149597 · Cited by 843 · see citing works
Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., & Goldstein, J. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118951 · Cited by 810 · see citing works
Self-citationShimomura, I., Bashmakov, Y. K., & Horton, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30028 · Cited by 704 · see citing works
Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., & Shimano, H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2961 · Cited by 703 · see citing works
Self-citationBrown, M. S., Faust, J. R., Goldstein, J. L., Kaneko, I., & Endo, A. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38120-6 · Cited by 556 · see citing works
Self-citationSakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S., & Goldstein, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81304-5 · Cited by 528 · see citing works
Self-citationSequence, structure, and codon preference of theDrosophilaribosomal protein 49 gene
O'Connell, P., & Rosbash, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.13.5495 · Cited by 519 · see citing works
Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein
Hua, X., Nohturfft, A., Goldstein, J. L., & Brown, M. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81362-8 · Cited by 474 · see citing works
Self-citationUnsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells
Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L., & Brown, M. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007273200 · Cited by 448 · see citing works
Self-citationSakai, J., Rawson, R. B., Espenshade, P. J., Cheng, D., Seegmiller, A. C., Goldstein, J. L., & Brown, M. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80150-1 · Cited by 405 · see citing works
Self-citationShimomura, I., Shimano, H., Korn, B. S., Bashmakov, Y. K., & Horton, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35299 · Cited by 383 · see citing works
Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes
Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S., & Espenshade, P. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00037-4 · Cited by 347 · see citing works
Self-citationMatsuda, M., Korn, B. S., Hammer, R. E., Moon, Y.-A., Komuro, R., Horton, J. D., Goldstein, J. L., Brown, M. S., & Shimomura, I. (2001) · Genes & Development · doi:10.1101/gad.891301 · Cited by 338 · see citing works
Self-citationTransport-Dependent Proteolysis of SREBP
DeBose‐Boyd, R. A., Brown, M. S., Li, W., Nohturfft, A., Goldstein, J. L., & Espenshade, P. J. (1999) · Cell · doi:10.1016/s0092-8674(00)81668-2 · Cited by 326 · see citing works
Self-citationWorgall, T. S., Sturley, S. L., Seo, T., Osborne, T. F., & Deckelbaum, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25537 · Cited by 322 · see citing works
Kim, J. B., Spotts, G. D., Halvorsen, Y. C., Shih, H., Ellenberger, T., Towle, H. C., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2582 · Cited by 320 · see citing works
The Absence of Sterol Synthesis in Insects
Clark, A. J., & Bloch, K. E. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69741-8 · Cited by 277 · see citing works
Luong, A., Hannah, V. C., Brown, M. S., & Goldstein, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004160200 · Cited by 266 · see citing works
Self-citationSakai, J., Nohturfft, A., Goldstein, J. L., & Brown, M. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5785 · Cited by 222 · see citing works
Self-citationDuncan, E. A., Brown, M. S., Goldstein, J. L., & Sakai, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12778 · Cited by 177 · see citing works
Self-citationRawson, R. B., DeBose‐Boyd, R. A., Goldstein, J. L., & Brown, M. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28549 · Cited by 171 · see citing works
Self-citationFine mapping of antigenic site II of herpes simplex virus glycoprotein D
Isola, V. J., Eisenberg, R. J., Siebert, G. R., Heilman, C. J., Wilcox, W. C., & Cohen, G. H. (1989) · Journal of Virology · doi:10.1128/jvi.63.5.2325-2334.1989 · Cited by 164 · see citing works
Duncan, E. A., Davé, U. P., Sakai, J., Goldstein, J. L., & Brown, M. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17801 · Cited by 157 · see citing works
Self-citationHua, X., Sakai, J., K., H. Y., Goldstein, J. L., & Brown, M. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29422 · Cited by 154 · see citing works
Self-citationYe, J., Davé, U. P., Grishin, N. V., Goldstein, J. L., & Brown, M. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5123 · Cited by 143 · see citing works
Self-citationNohturfft, A., Brown, M. S., & Goldstein, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12848 · Cited by 135 · see citing works
Self-citationHerz, J., Kowal, R. C., Ho, Y. K., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45368-3 · Cited by 119 · see citing works
Self-citationZelenski, N. G., Rawson, R. B., Brown, M. S., & Goldstein, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21973 · Cited by 114 · see citing works
Self-citationThewke, D. P., Panini, S. R., & Sinensky, M. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21402 · Cited by 76 · see citing works
Synthesis of Rauscher murine leukemia virus-specific polypeptides in vitro.
Gielkens, A. L. J., Zaane, D. V., Bloemers, H. P. J., & BLOEMENDAL, H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.2.356 · Cited by 75 · see citing works
Nohturfft, A., Hua, X., Brown, M. S., & Goldstein, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13709 · Cited by 60 · see citing works
Self-citationTheopold, U., Ekengren, S. K., & Hultmark, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1195 · Cited by 45 · see citing works
Biosynthesis of medium chain fatty acids in Drosophila melanogaster
de Renobales, M., & Blomquist, G. J. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90004-3 · Cited by 31 · see citing works
HLH106, a DrosophilaSterol Regulatory Element-binding Protein in a Natural Cholesterol Auxotroph
Rosenfeld, J. M., & Osborne, T. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16112 · Cited by 29 · see citing works
Hohturfft, A. (1996) · Medical Entomology and Zoology · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
van der Veen, J. N., Kennelly, J. P., Wan, S., Vance, J. E., Vance, D. E., & Jacobs, R. L. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.006 · Cited by 1,514 · see citing works
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works
Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B. H., Quintana, A., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.019 · Cited by 876 · see citing works
Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B., & Pan, D. (2002) · Nature Cell Biology · doi:10.1038/ncb847 · Cited by 719 · see citing works
Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M. F., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 617 · see citing works
Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700899104 · Cited by 593 · see citing works
Self-citationRegulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
Brown, M. S., & Goldstein, J. L. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800054-jlr200 · Cited by 491 · see citing works
Self-citationDiabetic Larvae and Obese Flies—Emerging Studies of Metabolism in Drosophila
Baker, K. D., & Thummel, C. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.002 · Cited by 467 · see citing works
A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Walker, A. K., Jacobs, R. L., Watts, J. L., Rottiers, V., Jiang, K., Finnegan, D. M., Shioda, T., Hansen, M., Yang, F., Niebergall, L. J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.045 · Cited by 466 · see citing works
THE MEVALONATE PATHWAY AND THE SYNTHESIS OF JUVENILE HORMONE IN INSECTS
Bellés, X., Martı́n, D., & Piulachs, M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130356 · Cited by 432 · see citing works
Phosphatidylethanolamine is a key regulator of membrane fluidity in eukaryotic cells
Dawaliby, R., Trubbia, C., Delporte, C., Noyon, C., Ruysschaert, J.-M., Van Antwerpen, P., & Govaerts, C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.706523 · Cited by 385 · see citing works
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works
Phospholipid biosynthesis in mammalian cells
Vance, J. E., & Vance, D. E. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-073 · Cited by 374 · see citing works
Walker, A. K., Yang, F., Jiang, K., Ji, J., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S. A., Smith, J. J., et al. (2010) · Genes & Development · doi:10.1101/gad.1901210 · Cited by 352 · see citing works
The SREBP pathway — insights from insigs and insects
Rawson, R. B. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1174 · Cited by 323 · see citing works
Self-citationSREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes, A. L., Todd, B. L., & Espenshade, P. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.012 · Cited by 320 · see citing works
Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in <i>Drosophila</i>
Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., & Rawson, R. B. (2002) · Science · doi:10.1126/science.1071124 · Cited by 318 · see citing works
Self-citationSterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Bertolio, R., Napoletano, F., Mano, M., Maurer‐Stroh, S., Fantuz, M., Zannini, A., Bicciato, S., Sorrentino, G., & Sal, G. D. (2019) · Nature Communications · doi:10.1038/s41467-019-09152-7 · Cited by 296 · see citing works
The ins and outs of endoplasmic reticulum‐controlled lipid biosynthesis
Jacquemyn, J., Cascalho, A. C. C., & Goodchild, R. E. (2017) · EMBO Reports · doi:10.15252/embr.201643426 · Cited by 289 · see citing works
Miyazaki, M., Dobrzyń, A., Man, W. C., Chu, K., Sampath, H., Kim, H.-J., & Ntambi, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402781200 · Cited by 283 · see citing works
Che, P., Bussell, J. D., Zhou, W., Estavillo, G. M., Pogson, B. J., & Smith, S. M. (2010) · Science Signaling · doi:10.1126/scisignal.2001140 · Cited by 270 · see citing works
Osborne, T. F., & Espenshade, P. J. (2009) · Genes & Development · doi:10.1101/gad.1854309 · Cited by 264 · see citing works
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Saba, J. D., & Hla, T. (2004) · Circulation Research · doi:10.1161/01.res.0000122383.60368.24 · Cited by 261 · see citing works
Kanehara, K., Ito, K., & Akiyama, Y. (2002) · Genes & Development · doi:10.1101/gad.1002302 · Cited by 258 · see citing works
Endocrine remodelling of the adult intestine sustains reproduction in Drosophila
Reiff, T., Jacobson, J., Cognigni, P., Antonello, Z. A., Ballesta‐Illán, E., Tan, K. J., Yew, J. Y., Domínguez, M., & Miguel‐Aliaga, I. (2015) · eLife · doi:10.7554/elife.06930 · Cited by 233 · see citing works
A journey into the world of insect lipid metabolism
Toprak, U., Hegedus, D. D., Doğan, C., & Güney, G. (2020) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21682 · Cited by 218 · see citing works
Triacylglycerol Metabolism in Drosophila melanogaster
Heier, C., & Kühnlein, R. P. (2018) · Genetics · doi:10.1534/genetics.118.301583 · Cited by 218 · see citing works
Obesity and the regulation of fat metabolism
Ashrafi, K. (2007) · WormBook · doi:10.1895/wormbook.1.130.1 · Cited by 204 · see citing works
A role for PPARα in the control of SREBP activity and lipid synthesis in the liver
Knight, B. L., Hebbachi, A., Hauton, D., Brown, A.-M., Wiggins, D. K., Patel, D. D., & Gibbons, G. F. (2005) · Biochemical Journal · doi:10.1042/bj20041896 · Cited by 188 · see citing works
Why do worms need cholesterol?
Kurzchalia, T. V., & Ward, S. F. (2003) · Nature Cell Biology · doi:10.1038/ncb0803-684 · Cited by 184 · see citing works
Control of fatty acid desaturation: a mechanism conserved from bacteria to humans
Aguilar, P. S., & de Mendoza, D. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05484.x · Cited by 180 · see citing works
Liu, Y., Wu, F.-Y., Tian, R.-Y., Shi, Y., Xu, Z.-Q., Liu, J.-Y., Huang, J., Xue, F.-F., Liu, B.-Y., & Liu, G. (2023) · Communications Biology · doi:10.1038/s42003-022-04154-6 · Cited by 178 · see citing works
Coordination of Lipid Metabolism in Membrane Biogenesis
Nohturfft, A., & Zhang, S. C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175344 · Cited by 175 · see citing works
Survival strategies of a sterol auxotroph
Carvalho, M., Schwudke, D., Sampaio, J. L., Palm, W., Riezman, I., Dey, G., Gupta, G. D., Mayor, S., Riezman, H., Shevchenko, A., et al. (2010) · Development · doi:10.1242/dev.044560 · Cited by 165 · see citing works
Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation
Hudry, B., de Goeij, E., Mineo, A., Gaspar, P., Hadjieconomou, D., Studd, C., Mokochinski, J. B., Kramer, H., Plaçais, P.-Y., Préat, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.029 · Cited by 159 · see citing works
SREBP-1c and lipogenesis in the liver: an update
Ferré, P., Phan, F., & Foufelle, F. (2021) · Biochemical Journal · doi:10.1042/bcj20210071 · Cited by 168 · see citing works
Schlegel, A., & Stainier, D. Y. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030199 · Cited by 159 · see citing works
Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism
Igal, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.009 · Cited by 159 · see citing works
Intramembrane proteolysis controls diverse signalling pathways throughout evolution
Urban, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00334-9 · Cited by 144 · see citing works
Insect Sterol Nutrition: Physiological Mechanisms, Ecology, and Applications
Jing, X., & Behmer, S. T. (2019) · Annual Review of Entomology · doi:10.1146/annurev-ento-011019-025017 · Cited by 141 · see citing works
Malathi, K., Higaki, K., Tinkelenberg, A. H., Balderes, D. A., Almanzar-Paramio, D., Wilcox, L. J., Erdeniz, N., Redican, F., Padamsee, M., Liu, Y., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310046 · Cited by 140 · see citing works
Fatty acid auxotrophy in Drosophila larvae lacking SREBP
Kunte, A. S., Matthews, K. A., & Rawson, R. B. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.011 · Cited by 139 · see citing works
Self-citationRole of TOR signaling in aging and related biological processes in Drosophila melanogaster
Katewa, S. D., & Kapahi, P. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.11.036 · Cited by 134 · see citing works
Wat, L. W., Chao, C. F., Bartlett, R., Buchanan, J. L., Millington, J. W., Chih, H. J., Chowdhury, Z. S., Biswas, P., Huang, V., Shin, L. J., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000595 · Cited by 137 · see citing works
COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication
Cherry, S. R., Kunte, A. S., Wang, H., Coyne, C. B., Rawson, R. B., & Perrimon, N. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020102 · Cited by 132 · see citing works
Self-citationMolecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolism
Vance, J. E. (2003) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(03)75003-x · Cited by 126 · see citing works
An allostatic control of membrane lipid composition by SREBP1
Hagen, R. M., Rodríguez‐Cuenca, S., & Vidal‐Puig, A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.004 · Cited by 126 · see citing works
Lim, H., Wang, W., Wessells, R. J., Ocorr, K. A., & Bodmer, R. (2011) · Genes & Development · doi:10.1101/gad.1992411 · Cited by 120 · see citing works
Isoprenoids Control Germ Cell Migration Downstream of HMGCoA Reductase
SANTOS, A. C. D. S., & Lehmann, R. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00023-1 · Cited by 120 · see citing works
Splyregulation of sphingolipid signaling molecules is essential for Drosophila development
Herr, D. R., Fyrst, H., Phan, V. H., Heinecke, K., Georges, R., Harris, G. L., & Saba, J. D. (2003) · Development · doi:10.1242/dev.00456 · Cited by 115 · see citing works
Adams, C. M., Goldstein, J. L., & Brown, M. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534833100 · Cited by 111 · see citing works
Self-citationCellular pathology of Niemann–Pick type C disease
Ikonen, E., & Hölttä‐Vuori, M. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.03.001 · Cited by 108 · see citing works
Kinch, L. N., Ginalski, K., & Grishin, N. V. (2005) · Protein Science · doi:10.1110/ps.051766506 · Cited by 105 · see citing works
Proteolysis and Sterol Regulation
Hampton, R. Y. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.032002.131219 · Cited by 104 · see citing works
Rong, S., Xia, M., Vale, G., Wang, S., Kim, C.-W., Li, S., McDonald, J. G., Radhakrishnan, A., & Horton, J. D. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.011 · Cited by 102 · see citing works
Diop, S. B., Bisharat‐Kernizan, J., Birse, R. T., Oldham, S., Ocorr, K. A., & Bodmer, R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.022 · Cited by 99 · see citing works
Zipper, L., Jassmann, D., Burgmer, S., Görlich, B., & Reiff, T. (2020) · eLife · doi:10.7554/elife.55795 · Cited by 98 · see citing works
Enzymes of Sphingolipid metabolism in Drosophila melanogaster
Acharya, U. R., & Acharya, J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4254-1 · Cited by 95 · see citing works
Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila
Bauer, R., Voelzmann, A., Breiden, B., Schepers, U., Farwanah, H., Hahn, I., Eckardt, F., Sandhoff, K., & Hoch, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.305 · Cited by 93 · see citing works
Hampton, R. Y., & Garza, R. M. (2009) · Chemical Reviews · doi:10.1021/cr800544v · Cited by 92 · see citing works
Porstmann, T., Santos, C. R., Lewis, C. A., Griffiths, B. L., & Schulze, A. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370278 · Cited by 92 · see citing works
Kniazeva, M., Sieber, M., McCauley, S., Zhang, K., Watts, J. L., & Han, M. (2003) · Genetics · doi:10.1093/genetics/163.1.159 · Cited by 92 · see citing works
Yabe, D., Xia, Z., Adams, C. M., & Rawson, R. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262669399 · Cited by 89 · see citing works
Self-citationMoon, Y.-A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E., & Horton, J. D. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m054353 · Cited by 83 · see citing works
Niwa, R., & Niwa, Y. S. (2011) · Cholesterol · doi:10.1155/2011/176802 · Cited by 82 · see citing works
Rava, P., Ojakian, G. K., Shelness, G. S., & Hussain, M. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512823200 · Cited by 81 · see citing works
The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?
Babin, P. J., & Gibbons, G. F. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.002 · Cited by 78 · see citing works
Worgall, T. S., Juliano, R. A., Seo, T., & Deckelbaum, R. J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125703.20434.4d · Cited by 73 · see citing works
Maguire, S. L., Wang, C., Holland, L. M., Brunel, F., Neuvéglise, C., Nicaud, J.-M., Zavrel, M., White, T. C., Wolfe, K. H., & Butler, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004076 · Cited by 69 · see citing works
Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP
Ziegler, A. B., Thiele, C., Tenedini, F. M., Richard, M., Leyendecker, P., Hoermann, A., Soba, P., & Tavosanis, G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.069 · Cited by 68 · see citing works
Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes
Ren, S., Li, X., Rodríguez‐Agudo, D., Gil, G., Hylemon, P. B., & Pandak, W. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.143 · Cited by 61 · see citing works
Bujold, M., Gopalakrishnan, A., Nally, E., & King‐Jones, K. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01327-09 · Cited by 61 · see citing works
Matsuoka, S., Armstrong, A. R., Sampson, L. L., Laws, K. M., & Drummond‐Barbosa, D. (2017) · Genetics · doi:10.1534/genetics.117.201921 · Cited by 63 · see citing works
The Role of Nuclear Receptor NHR-64 in Fat Storage Regulation in Caenorhabditis elegans
Liang, B., Ferguson, K., Kadyk, L. C., & Watts, J. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009869 · Cited by 60 · see citing works
Rawson, R. B. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.03.031 · Cited by 59 · see citing works
Self-citationEndocrine and physiological regulation of neutral fat storage in Drosophila
Lehmann, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.008 · Cited by 56 · see citing works
Bonaventure, G., Bao, X., Ohlrogge, J. B., & Pollard, M. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.043372 · Cited by 55 · see citing works
Sterols and sphingolipids: Dynamic duo or partners in crime?
Gulati, S., Liu, Y., Munkacsi, A. B., Wilcox, L. J., & Sturley, S. L. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.03.003 · Cited by 53 · see citing works
Montooth, K. L., Siebenthall, K. T., & Clark, A. G. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02448 · Cited by 53 · see citing works
Tittiger, C., Barkawi, L. S., Bengoa, C. S., Blomquist, G. J., & Seybold, S. J. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00358-1 · Cited by 52 · see citing works
Tian, H., Luo, J., Zhang, Z., Wu, J., Zhang, T., Busato, S., Huang, L., Song, N., & Bionaz, M. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03545 · Cited by 51 · see citing works
Regulation of fatty acid and cholesterol synthesis: co-operation or competition?
Gibbons, G. F. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00034-1 · Cited by 51 · see citing works
Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death
Kanda, H., Igaki, T., Okano, H., & Miura, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103242108 · Cited by 49 · see citing works
Herr, D. R., Fyrst, H., Creason, M. B., Phan, V. H., Saba, J. D., & Harris, G. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310647200 · Cited by 50 · see citing works
DROSOPHILA NUTRIGENOMICS CAN PROVIDE CLUES TO HUMAN GENE-NUTRIENT INTERACTIONS
Ruden, D. M., Luca, M. D., Garfinkel, M. D., Bynum, K. L., & Lu, X. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092708 · Cited by 48 · see citing works
Glycerophospholipids – Emerging players in neuronal dendrite branching and outgrowth
Ziegler, A. B., & Tavosanis, G. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.12.009 · Cited by 47 · see citing works
Xie, X.-J., Hsu, F.-N., Gao, X., Xu, W., Ni, J.-Q., Xing, Y., Huang, L.-Y., Hsiao, H., Zheng, H., Wang, C., et al. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002207 · Cited by 44 · see citing works
Substrate Recognition and Binding by RseP, an Escherichia coli Intramembrane Protease
Koide, K., Ito, K., & Akiyama, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709984200 · Cited by 45 · see citing works
Osipova, D., Kokoreva, K., Лазебник, Л. Б., Голованова, Е. В., Pavlov, C. S., Духанин, А. С., Orlova, S., & Starostin, K. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.797923 · Cited by 45 · see citing works
Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)
Jaramillo-Madrid, A. C., Ashworth, J. R., Fabris, M., & Ralph, P. J. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.03.018 · Cited by 43 · see citing works
Franta, Z., Vogel, H., Lehmann, R., Rupp, O., Goesmann, A., & Vilcinskas, A. (2016) · BioMed Research International · doi:10.1155/2016/8285428 · Cited by 42 · see citing works
Recent advances in branching mechanisms underlying neuronal morphogenesis
Menon, S., & Gupton, S. L. (2018) · F1000Research · doi:10.12688/f1000research.16038.1 · Cited by 38 · see citing works
Sterol and Steroid Biosynthesis and Metabolism in Plants and Microorganisms
Schaller, H. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00008-3 · Cited by 38 · see citing works
Gaining Insights into Diabetic Cardiomyopathy from Drosophila
Diop, S. B., & Bodmer, R. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.009 · Cited by 38 · see citing works
Sánchez‐Álvarez, M., Zhang, Q., Finger, F., Wakelam, M. J. O., & Bakal, C. (2015) · Open Biology · doi:10.1098/rsob.150093 · Cited by 38 · see citing works
Sphingolipid Synthetic Pathways are Major Regulators of Lipid Homeostasis
Worgall, T. S. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1_9 · Cited by 37 · see citing works
Dobrosotskaya, I. Y., Goldstein, J. L., Brown, M. S., & Rawson, R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306476200 · Cited by 37 · see citing works
Self-citationLige, B., Romano, J. D., Bandaru, V. V. R., Ehrenman, K., Levitskaya, J., Sampels, V., Haughey, N. J., & Coppens, I. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002410 · Cited by 36 · see citing works
BARBER, M. C., VALLANCE, A. J., Kennedy, H. T., & Travers, M. T. (2003) · Biochemical Journal · doi:10.1042/bj20030480 · Cited by 36 · see citing works
- Authors
- Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Goldstein, Joseph L.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 2
- Issue
- 2
- Pages
- 229-238
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1993125269
- Cited by
- 194
- References
- 45
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 12 · 2023: 10 · 2022: 8 · 2021: 3 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- National Institute of General Medical Sciences (GM-08014, T32GM008014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- SREBP pathway, SCAP, palmitic acid, fatty acid synthesis, sterol biosynthesis, isoprenoid biosynthesis, membrane integrity, cholesterol homeostasis, Drosophila, S2 cells, transcriptional regulation
- MeSH terms
- Animals, Cell Line, DNA-Binding Proteins, Drosophila, Fatty Acids, Humans, Membrane Proteins, Mutation, Peptide Fragments, Protein Processing, Post-Translational, RNA, Double-Stranded, RNA, Messenger, Sterols, Transcription Factors, Blotting, Western, Polymerase Chain Reaction, Sequence Homology, Amino Acid, Pyruvic Acid, Palmitic Acid, CCAAT-Enhancer-Binding Proteins, Intracellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review