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Inhibition of the immune response by rapamycin, a new antifungal antibiotic
Abstract
Rapamycin, a new antifungal antibiotic, was found to inhibit the immune response in rats. It totally prevented the development of two experimental immunopathies (experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)) and the formation of humoral (IgE-like) antibody. It was about half as potent as cyclophosphamide in inhibiting EAE. In AA and on antibody formation, rapamycin and cyclophosphamide were about equipotent, whereas methotrexate was more potent. The immunosuppressant activity of rapamycin appears to be related to inhibition of the lymphatic system.
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Citations
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Metadata
- Authors
- Martel, R. R., Klicius, J., & Galet, S.
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 1977-02-01
- Volume
- 55
- Issue
- 1
- Pages
- 48-51
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W1976726113
- Cited by
- 463
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of the immune response by rapamycin, a new antifungal antibiotic. https://app.cochat.ai/papers/10.1139/y77-007
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- Martel, R. R., Klicius, J., & Galet, S. (1977). Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Canadian Journal of Physiology and Pharmacology. https://doi.org/10.1139/y77-007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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