Atropine-Induced HRV Alteration is Not Amended by Electroacupuncture on Zusanli
Abstract
Acupuncture is known to influence autonomic nervous activity. Acupuncture on Zusanli points has been shown to enhance the regularity of gastric myoelectrical activity and accelerate gastric emptying, partly through the vagal pathway, in dogs. The aim of this study was to evaluate whether atropine-induced autonomic nervous alteration, measured by heart rate variability (HRV), could be amended by electroacupuncture on Zusanli points. HRV measurements were recorded in 15 healthy volunteers before, during and after electroacupuncture. Each subject was studied for three sessions in a randomized sequence, which included electroacupuncture on the Zusanli (St 36) points with or without premedication of atropine and placebo stimulation on a non-acupoint. The analysis of low frequency (LF), high frequency (HF) and LF/HF ratios were compared between different sessions. Serum levels of gastrin, motilin and pancreatic polypeptide (PP) levels were also measured. There was an increase in the LF/HF ratio (indicating increased sympathetic activity) during the post-acupuncture period with 2 Hz of electrical stimulation on the Zusanli acupoints. When IV atropine was used immediately before the electroacupuncture, there was a decrease in the LF power and HF power during the acupuncture and post-acupuncture periods. In addition, there was a significant increase in the LF/HF ratio during the acupuncture and post-acupuncture periods. There was a significant decrease in serum PP in the post-acupuncture period after premedication with IV atropine. In conclusion, atropine-induced HRV change might be mediated via the vagal pathway. However, atropine-induced HRV alteration is not amended by electroacupuncture on Zusanli points.
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Acupuncture can elicit measurable increases in vagus nerve activity.
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From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [67]
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Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · see citing works
- Authors
- Chang, C.-H., Huang, J.-L., Ting, C.-T., Chang, C.-S., & Chen, G.-H.
- Affiliations
- National Chung Hsing University (TW)
- Taichung Veterans General Hospital (TW)
- Venue
- The American Journal of Chinese Medicine
- Publisher
- World Scientific Pub Co Pte Lt
- Published
- 2005-01
- Volume
- 33
- Issue
- 02
- Pages
- 307-314
- ISSN
- 0090-2942 (ISSN-L)
- 0192-415X
- 1793-6853
- OpenAlex
- W2107926040
- Cited by
- 37
- References
- 19
- Citations by year
- 2021: 3 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 6
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Chinese Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Taichung Veterans General Hospital
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- electroacupuncture, Zusanli (ST36), atropine, heart rate variability, vagal pathway, autonomic nervous system, sympathetic activity, LF/HF ratio, gastric myoelectrical activity, gastric emptying, gastrin, motilin, pancreatic polypeptide
- MeSH terms
- Adult, Anti-Arrhythmia Agents, Atropine, Autonomic Nervous System, Heart Rate, Humans, Infusions, Intravenous, Male, Placebos, Electroacupuncture
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