The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages
Abstract
In this study, we found that alpha-pinene (α-pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-κB) pathway in mouse peritoneal macrophages. α-Pinene is found in the oils of many coniferous trees and rosemary. We investigated the inhibitory effects of α-Pinene on inflammatory responses induced by lipopolysaccharide (LPS) using mouse peritoneal macrophages. α-Pinene significantly decreased the LPS-induced production of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nitric oxide (NO). α-Pinene also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in LPS-stimulated macrophages. Additionally, the activations of MAPKs and NF-κB were attenuated by means of α-pinene treatment. These results indicate that α-pinene has an anti-inflammatory effect and that it is a potential candidate as a new drug to treat various inflammatory diseases.
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Cites
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Prostanoid Receptors: Subtypes and Signaling
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TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway
Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.-H., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00210-5 · Cited by 801
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Cited by
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Kim, T., Song, B., Cho, K. S., & Lee, I.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062187 · Cited by 281
Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review
Antonelli, M., Donelli, D., Barbieri, G., Valussi, M., Maggini, V., & Firenzuoli, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186506 · Cited by 237
Metadata
- Authors
- Kim, D.-S., Lee, H.-J., Jeon, Y.-D., Han, Y.-H., Kee, J.-Y., Kim, H.-J., Shin, H.-J., Kang, J., Lee, B. S., Kim, S.-H., Kim, S.-J., Park, S.-H., Choi, B.-M., Park, S.-J., Um, J.-Y., & Hong, S.-H.
- Venue
- The American Journal of Chinese Medicine
- Publisher
- World Scientific Pub Co Pte Ltd
- Published
- 2015-01
- Volume
- 43
- Issue
- 04
- Pages
- 731-742
- ISSN
- 0090-2942 (ISSN-L)
- 0192-415X
- 1793-6853
- OpenAlex
- W1851103126
- Cited by
- 277
- References
- 28
- FWCI
- 20.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, D.-S., Lee, H.-J., Jeon, Y.-D., Han, Y.-H., Kee, J.-Y., Kim, H.-J., Shin, H.-J., Kang, J., Lee, B. S., Kim, S.-H., Kim, S.-J., Park, S.-H., Choi, B.-M., Park, S.-J., Um, J.-Y., & Hong, S.-H. (2015). Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages. The American Journal of Chinese Medicine. https://doi.org/10.1142/s0192415x15500457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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