The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
NITRIC OXIDE AND MACROPHAGE FUNCTION
Abstract
▪ Abstract At the interface between the innate and adaptive immune systems lies the high-output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine requires at least 17 binding reactions to assemble a functional dimer. Sustained catalysis results from the ability of NOS2 to attach calmodulin without dependence on elevated Ca 2+. Expression of NOS2 in macrophages is controlled by cytokines and microbial products, primarily by transcriptional induction. NOS2 has been documented in macrophages from human, horse, cow, goat, sheep, rat, mouse, and chicken. Human NOS2 is most readily observed in monocytes or macrophages from patients with infectious or inflammatory diseases. Sustained production of NO endows macrophages with cytostatic or cytotoxic activity against viruses, bacteria, fungi, protozoa, helminths, and tumor cells. The antimicrobial and cytotoxic actions of NO are enhanced by other macrophage products such as acid, glutathione, cysteine, hydrogen peroxide, or superoxide. Although the high-output NO pathway probably evolved to protect the host from infection, suppressive effects on lymphocyte proliferation and damage to other normal host cells confer upon NOS2 the same protective/destructive duality inherent in every other major component of the immune response.
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Cites
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Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
HOW CELLS RESPOND TO INTERFERONS
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Metadata
- Authors
- MacMicking, J., Xie, Q.-W., & Nathan, C.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1997-04
- Volume
- 15
- Issue
- 1
- Pages
- 323-350
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2149200346
- Cited by
- 4,211
- References
- 9
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacMicking, J., Xie, Q.-W., & Nathan, C. (1997). NITRIC OXIDE AND MACROPHAGE FUNCTION. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.15.1.323
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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