The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Open accessAbstract
Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Bai, J., Zheng, Y., Wang, G., & Liu, P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5962832 · Cited by 73
RetractedNF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
The Nuclear Factor NF- B Pathway in Inflammation
Lawrence, T. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001651 · Cited by 4,898
Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
A global model of natural volatile organic compound emissions
Guenther, A., Hewitt, C. N., Erickson, D., Fall, R., Geron, C., Graedel, T., Harley, P., Klinger, L., Lerdau, M., Mckay, W. A., et al. (1995) · Journal of Geophysical Research: Atmospheres · doi:10.1029/94jd02950 · Cited by 4,169
The function of terpene natural products in the natural world
Gershenzon, J., & Dudareva, N. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.5 · Cited by 2,167
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies
Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J., & Xu, J. (2018) · Bone Research · doi:10.1038/s41413-018-0016-9 · Cited by 1,767
Cited by
Masyita, A., Mustika Sari, R., Dwi Astuti, A., Yasir, B., Rahma Rumata, N., Emran, T. B., Nainu, F., & Simal-Gandara, J. (2022) · Food Chemistry: X · doi:10.1016/j.fochx.2022.100217 · Cited by 1,052
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
He, Y.-Q., Zhou, C.-C., Yu, L.-Y., Wang, L., Deng, J.-L., Tao, Y.-L., Zhang, F., & Chen, W.-S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105224 · Cited by 412
Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review
Antonelli, M., Donelli, D., Barbieri, G., Valussi, M., Maggini, V., & Firenzuoli, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186506 · Cited by 237
Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper
Fieten, K. B., Drijver‐Messelink, M. T., Cogo, A., Charpin, D., Sokolowska, M., Agache, I., Taborda‐Barata, L. M., Eguiluz‐Gracia, I., Braunstahl, G. J., Seys, S. F., et al. (2022) · Allergy · doi:10.1111/all.15242 · Cited by 45
Donelli, D., Meneguzzo, F., Antonelli, M., Ardissino, D., Niccoli, G., Gronchi, G., Baraldi, R., Neri, L., & Zabini, F. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20042773 · Cited by 31
Metadata
- Authors
- Kim, T., Song, B., Cho, K. S., & Lee, I.-S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-22
- Volume
- 21
- Issue
- 6
- Pages
- 2187
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3012818802
- Cited by
- 281
- References
- 164
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases. https://app.cochat.ai/papers/10.3390/ijms21062187
- The paper
- Kim, T., Song, B., Cho, K. S., & Lee, I.-S. (2020). Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21062187
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
