MESOBIOTIC EMERGENCE: MOLECULAR AND ENSEMBLE COMPLEXITY IN EARLY EVOLUTION
Abstract
In addition to the visible complexity expressed in the morphogenesis of multicellular organisms, two levels of microscopic complexity may be discerned within every living cell. The first level is related to covalently bonded structures, namely molecules. The second level has to do with the generation of non-covalent molecular assemblies. Origin of life research has largely focused on the first complexity level, i.e. the appearance of covalent biopolymers. We present a life emergence scenario based mainly on the second complexity level. We argue that homeostatic molecular ensembles, for which we have coined the term "mesobiotic," have assumed a half-way position between prebiotic organic synthesis and full-fledged cellular (biotic) life.
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A very large initial molecular repertoire is a necessary condition for the GARD model to operate.
“In fact, a very large initial molecular repertoire is a necessary condition for the GARD model to operate [47].”
From Systems protobiology: origin of life in lipid catalytic networks (2018) · cites this paper as [47]
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- Authors
- SHENHAV, B., SEGRÈ, D., & LANCET, D.
- Affiliations
- Crown Human Genome Center (IL)
- Harvard University (US)
- Venue
- Advances in Complex Systems
- Publisher
- World Scientific Pub Co Pte Ltd
- Published
- 2003-03
- Volume
- 06
- Issue
- 01
- Pages
- 15-35
- ISSN
- 0219-5259 (ISSN-L)
- 1793-6802
- OpenAlex
- W2007282744
- Cited by
- 37
- References
- 9
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Complex Systems (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- origin of life, molecular ensembles, prebiotic chemistry, early evolution, homeostasis, molecular complexity
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