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Cited by 64Genomics and Chromatin DynamicsNuclear Structure and FunctionChromatin Remodeling and Cancer

Weak interactions in higher-order chromatin organization

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Kantidze, Omar L, Razin, Sergey V·2020·Nucleic Acids Research
DOI 10.1093/nar/gkaa261PMC PMC7229822
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Abstract

The detailed principles of the hierarchical folding of eukaryotic chromosomes have been revealed during the last two decades. Along with structures composing three-dimensional (3D) genome organization (chromatin compartments, topologically associating domains, chromatin loops, etc.), the molecular mechanisms that are involved in their establishment and maintenance have been characterized. Generally, protein-protein and protein-DNA interactions underlie the spatial genome organization in eukaryotes. However, it is becoming increasingly evident that weak interactions, which exist in biological systems, also contribute to the 3D genome. Here, we provide a snapshot of our current understanding of the role of the weak interactions in the establishment and maintenance of the 3D genome organization. We discuss how weak biological forces, such as entropic forces operating in crowded solutions, electrostatic interactions of the biomolecules, liquid-liquid phase separation, DNA supercoiling, and RNA environment participate in chromosome segregation into structural and functional units and drive intranuclear functional compartmentalization.

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  • Current results strongly suggest that the demixing of enhancer- and promoter-associated proteins results in the assembly of a phase condensate that keeps the enhancer and promoter in spatial proximity.

    “Current results strongly suggest that the demixing of enhancer- and promoter-associated proteins results in the assembly of a phase condensate that keeps the enhancer and promoter in spatial proximity [97,98,99].”

    From Enhancer Function in the 3D Genome (2023) · cites this paper as [99]

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Cited by

Sorted by citations

Authors
Kantidze, O. L., & Razin, S. V.
Affiliations
Russian Academy of Sciences (RU)
Corresponding author
Razin, Sergey V
ORCID
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2020-04-20
Volume
48
Issue
9
Pages
4614-4626
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gkaa261
PMC
PMC7229822
OpenAlex
W3016788739
Cited by
64
References
18
Citations by year
2026: 2 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 19 · 2020: 4 · 2019: 2
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Nucleic Acids Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Russian Science Foundation (19-14-00016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
weak interaction, 3D genome organization, chromatin folding, chromatin compartments, topologically associating domains, chromatin looping, entropic force, electrostatic interactions, liquid-liquid phase separation, DNA supercoiling, RNA, nuclear compartmentalization, chromosome segregation
MeSH terms
Chromatin, DNA, Superhelical, RNA, Static Electricity

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