Cited by 378Chemical Synthesis and AnalysisDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques

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DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

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Neri, Dario, Lerner, Richard A.·2018·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-062917-012550PMC PMC6080696

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Abstract

The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology, and the biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification bar codes, allows the construction and screening of combinatorial libraries of unprecedented size, thus facilitating the discovery of ligands to many different protein targets. Fundamentally, one links powers of genetics and chemical synthesis. After the initial description of DNA-encoded chemical libraries in 1992, several experimental embodiments of the technology have been reduced to practice. This review provides a historical account of important milestones in the development of DNA-encoded chemical libraries, a survey of relevant ongoing research activities, and a glimpse into the future.

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Authors: Neri, D., & Lerner, R. A.
Affiliations: ETH Zurich (CH)
Scripps Research Institute (US)
ORCID: Neri, Dario
Lerner, Richard A.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2018-06-20
Volume: 87
Issue: 1
Pages: 479-502
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-062917-012550
PMC: PMC6080696
OpenAlex: W2782995788
Cited by: 364
References: 97
Citations by year: 2026: 26 · 2025: 32 · 2024: 27 · 2023: 34 · 2022: 42 · 2021: 63 · 2020: 81 · 2019: 46 · 2018: 13
FWCI: 5.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030B_163479/1, 163479, 160699)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords: DNA-encoded libraries, DNA barcoding, combinatorial libraries, protein-ligand binding, ligand discovery, library screening, molecular identification
MeSH terms: Animals, Humans, Ligands, Gene Library, Peptide Library, Combinatorial Chemistry Techniques, Small Molecule Libraries, Drug Discovery

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DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

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