The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Long Noncoding RNAs: Molecular Modalities to Organismal Functions
Abstract
We have known for decades that long noncoding RNAs (lncRNAs) can play essential functions across most forms of life. The maintenance of chromosome length requires an lncRNA (e.g., hTERC) and two lncRNAs in the ribosome that are required for protein synthesis. Thus, lncRNAs can represent powerful RNA machines. More recently, it has become clear that mammalian genomes encode thousands more lncRNAs. Thus, we raise the question: Which, if any, of these lncRNAs could also represent RNA-based machines? Here we synthesize studies that are beginning to address this question by investigating fundamental properties of lncRNA genes, revealing new insights into the RNA structure–function relationship, determining cis - and trans -acting lncRNAs in vivo, and generating new developments in high-throughput screening used to identify functional lncRNAs. Overall, these findings provide a context toward understanding the molecular grammar underlying lncRNA biology.
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Molecular Mechanisms of Long Noncoding RNAs
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Self-citationEvolution and Functions of Long Noncoding RNAs
Ponting, C. P., Oliver, P. L., & Reik, W. (2009) · Cell · doi:10.1016/j.cell.2009.02.006 · Cited by 4,208
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Self-citationUnique features of long non-coding RNA biogenesis and function
Quinn, J. J., & Chang, H. Y. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2015.10 · Cited by 3,672
Self-citationCabili, M. N., Trapnell, C., Goff, L., Koziol, M., Tazon-Vega, B., Regev, A., & Rinn, J. L. (2011) · Genes & Development · doi:10.1101/gad.17446611 · Cited by 3,502
Self-citationGenome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature · doi:10.1038/nature14136 · Cited by 2,825
lincRNAs: Genomics, Evolution, and Mechanisms
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Modular regulatory principles of large non-coding RNAs
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Self-citationA Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
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Cited by
Long non-coding RNAs: definitions, functions, challenges and recommendations
Mattick, J. S., Amaral, P. P., Carninci, P., Carpenter, S., Chang, H. Y., Chen, L.-L., Chen, R., Dean, C., Dinger, M. E., Fitzgerald, K. A., et al. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00566-8 · Cited by 2,356
Self-citationDavis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
Lee, J.-H., Wang, R., Xiong, F., Krakowiak, J., Liao, Z., Nguyen, P. T., Moroz-Omori, E. V., Shao, J., Zhu, X., Bolt, M. J., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.024 · Cited by 258
Genome-Wide analysis of human long noncoding RNAs: a provocative review
Ponting, C. P., & Haerty, W. (2022) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-112921-123710 · Cited by 115
Metadata
- Authors
- Rinn, J. L., & Chang, H. Y.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2020-06-20
- Volume
- 89
- Issue
- 1
- Pages
- 283-308
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W3036354173
- Cited by
- 282
- References
- 134
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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