The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications
Open accessAbstract
Microbial rhodopsins are a family of photoactive retinylidene proteins widespread throughout the microbial world. They are notable for their diversity of function, using variations of a shared seven-transmembrane helix design and similar photochemical reactions to carry out distinctly different light-driven energy and sensory transduction processes. Their study has contributed to our understanding of how evolution modifies protein scaffolds to create new protein chemistry, and their use as tools to control membrane potential with light is fundamental to optogenetics for research and clinical applications. We review the currently known functions and present more in-depth assessment of three functionally and structurally distinct types discovered over the past two years: (a) anion channelrhodopsins (ACRs) from cryptophyte algae, which enable efficient optogenetic neural suppression; (b) cryptophyte cation channelrhodopsins (CCRs), structurally distinct from the green algae CCRs used extensively for neural activation and from cryptophyte ACRs; and (c) enzymerhodopsins, with light-gated guanylyl cyclase or kinase activity promising for optogenetic control of signal transduction.
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Cites
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Cited by
Infrared Difference Spectroscopy of Proteins: From Bands to Bonds
Lorenz-Fonfria, V. A. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00449 · Cited by 325
Lamm, G. H. U., Marin, E., Alekseev, A., Schellbach, A. V., Stetsenko, A., Haro-Moreno, J. M., Bourenkov, G., Borshchevskiy, V., Asido, M., Agthe, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv1015 · Cited by 7
Metadata
- Authors
- Govorunova, E. G., Sineshchekov, O. A., Li, H., & Spudich, J. L.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2017-06-20
- Volume
- 86
- Issue
- 1
- Pages
- 845-872
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2559574135
- Cited by
- 363
- References
- 138
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Govorunova, E. G., Sineshchekov, O. A., Li, H., & Spudich, J. L. (2017). Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-101910-144233
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