Cited by 860Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismBacterial Cancer Therapy

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Glutaminolysis: A Hallmark of Cancer Metabolism

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Yang, Lifeng, Venneti, Sriram, Nagrath, Deepak·2017·Annual Review of Biomedical Engineering

DOI 10.1146/annurev-bioeng-071516-044546

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Abstract

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for many fundamental cell functions in cancer cells, including synthesis of metabolites that maintain mitochondrial metabolism; generation of antioxidants to remove reactive oxygen species; synthesis of nonessential amino acids (NEAAs), purines, pyrimidines, and fatty acids for cellular replication; and activation of cell signaling. In light of the pleiotropic role of glutamine in cancer cells, a comprehensive understanding of glutamine metabolism is essential for the development of metabolic therapeutic strategies for targeting cancer cells. In this article, we review oncogene-, tumor suppressor–, and tumor microenvironment–mediated regulation of glutamine metabolism in cancer cells. We describe the mechanism of glutamine's regulation of tumor proliferation, metastasis, and global methylation. Furthermore, we highlight the therapeutic potential of glutamine metabolism and emphasize that clinical application of in vivo assessment of glutamine metabolism is critical for identifying new ways to treat patients through glutamine-based metabolic therapy.

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Authors: Yang, L., Venneti, S., & Nagrath, D.
Affiliations: Rice University (US)
University of Michigan (US)
ORCID: Yang, Lifeng
Venneti, Sriram
Nagrath, Deepak
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2017-06-21
Volume: 19
Issue: 1
Pages: 163-194
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev-bioeng-071516-044546
OpenAlex: W2534904302
Cited by: 859
References: 171
Citations by year: 2026: 68 · 2025: 140 · 2024: 137 · 2023: 132 · 2022: 126 · 2021: 98 · 2020: 71 · 2019: 46 · 2018: 28 · 2017: 13
FWCI: 4.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Rice Research Repository (Rice University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: glutamine metabolism, glutaminolysis, cancer metabolism, tumor microenvironment, oncogenes, tumor suppressor, metastasis, global DNA methylation, tumor cell proliferation, metabolic therapy, reactive oxygen species, purine and pyrimidine synthesis, signal transduction
MeSH terms: Animals, Cell Transformation, Neoplastic, Glutamine, Humans, Mitochondria, Models, Biological, Neoplasms, Biomarkers, Tumor, Signal Transduction, Cell Proliferation

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Glutaminolysis: A Hallmark of Cancer Metabolism

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