Cited by 860Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismBacterial Cancer Therapy

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Glutaminolysis: A Hallmark of Cancer Metabolism

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Yang, Lifeng, Venneti, Sriram, Nagrath, Deepak·2017·Annual Review of Biomedical Engineering

DOI 10.1146/annurev-bioeng-071516-044546

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Abstract

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for many fundamental cell functions in cancer cells, including synthesis of metabolites that maintain mitochondrial metabolism; generation of antioxidants to remove reactive oxygen species; synthesis of nonessential amino acids (NEAAs), purines, pyrimidines, and fatty acids for cellular replication; and activation of cell signaling. In light of the pleiotropic role of glutamine in cancer cells, a comprehensive understanding of glutamine metabolism is essential for the development of metabolic therapeutic strategies for targeting cancer cells. In this article, we review oncogene-, tumor suppressor–, and tumor microenvironment–mediated regulation of glutamine metabolism in cancer cells. We describe the mechanism of glutamine's regulation of tumor proliferation, metastasis, and global methylation. Furthermore, we highlight the therapeutic potential of glutamine metabolism and emphasize that clinical application of in vivo assessment of glutamine metabolism is critical for identifying new ways to treat patients through glutamine-based metabolic therapy.

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Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 3×
“In order to systematically understand the role of metabolic reprogramming in cancer cells on establishing and maintaining a tumorigenic status, Pavlova & Thompson (2) summarized”
Background
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 1×
“As tumors develop, cancer cells recruit nonmalignant stromal cells in their vicinity to form a highly interactive tumor microenvironment (137).”
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472

Show all 171 references

Research works printed but not linked: 8

Smolke CD, 2010, The Metabolic Pathway Engineering Handbook: Fundamentals
Matsuno T, 1992, Cancer Res, 52, 1192
10.1038/nature12040 · DOI · Paper page
10.1016/j.cell.2015.07.016 · DOI · Paper page
Pizer ES, 1996, Cancer Res, 56, 1189
Levine B, 2015, J. Clin. Investig., 12514
Majós C, 2004, Am. J. Neuroradiol., 25, 1696
10.1158/1535-7163.MCT-13-0870 · DOI · Paper page

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Wang, H., Lu, J. L., Kulkarni, S., Zhang, W., Gorka, J. E., Mandel, J. A., Goetzman, E. S., & Prochownik, E. V. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005200 · Cited by 29
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Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges
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Zhou, Y.-J., Yu, H., Cheng, S., Chen, Y., He, L., Ren, J., He, X. Q., Chen, J., Zheng, L., Li, F., et al. (2022) · Journal of Cancer · doi:10.7150/jca.64195 · Cited by 28
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The interplay of the circadian clock and metabolic tumorigenesis
Wang, Z., Ma, L., Meng, Y., Fang, J., Xu, D., & Lu, Z. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.11.004 · Cited by 31
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Solsona, B. G., Horn, H., Schmitt, A., Xu, W., Bucher, P., Heinrich, A., Kalmbach, S., Kreienkamp, N., Franke, M., Wimmers, F., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010964 · Cited by 26
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Zhao, Z., Cao, Y., Xu, R. F., Fang, J., Zhang, Y., Xu, X., Huang, L., & Li, R. (2024) · Smart Materials in Medicine · doi:10.1016/j.smaim.2024.03.003 · Cited by 27
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Authors: Yang, L., Venneti, S., & Nagrath, D.
Affiliations: Rice University (US)
University of Michigan (US)
ORCID: Yang, Lifeng
Venneti, Sriram
Nagrath, Deepak
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2017-06-21
Volume: 19
Issue: 1
Pages: 163-194
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev-bioeng-071516-044546
OpenAlex: W2534904302
Cited by: 859
References: 171
Citations by year: 2026: 68 · 2025: 140 · 2024: 137 · 2023: 132 · 2022: 126 · 2021: 98 · 2020: 71 · 2019: 46 · 2018: 28 · 2017: 13
FWCI: 4.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Rice Research Repository (Rice University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: glutamine metabolism, glutaminolysis, cancer metabolism, tumor microenvironment, oncogenes, tumor suppressor, metastasis, global DNA methylation, tumor cell proliferation, metabolic therapy, reactive oxygen species, purine and pyrimidine synthesis, signal transduction
MeSH terms: Animals, Cell Transformation, Neoplastic, Glutamine, Humans, Mitochondria, Models, Biological, Neoplasms, Biomarkers, Tumor, Signal Transduction, Cell Proliferation

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Glutaminolysis: A Hallmark of Cancer Metabolism

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