The DOI matches its Crossref record; 187 of the 189 references it cites were found in a registry or an index.
Sculpting Organs: Mechanical Regulation of Tissue Development
Abstract
The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.
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“Finally, it has become increasingly clear that the mechanical properties in three-dimensional (3D) culture systems can have large effects on cell51, organoid52, tissue53, and organ development54,55.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [53]
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Metadata
- Authors
- Nelson, C. M., & Gleghorn, J. P.
- Affiliations
- Princeton University (US)
- Department of Chemical and Biological Engineering and
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2012-08-15
- Volume
- 14
- Issue
- 1
- Pages
- 129-154
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2170979166
- Cited by
- 130
- References
- 189
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 3
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Susan G. Komen
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R21HL110335, HL110335)
- National Cancer Institute (CA128660, R21CA128660)
- National Institute of General Medical Sciences (R01GM083997, GM083997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- branching morphogenesis, organogenesis, cell contractility, mechanical regulation, mammary gland, lung development, epithelial sheets, microenvironment, tissue mechanics
- MeSH terms
- Animals, Biomedical Engineering, Humans, Lung, Mammary Glands, Animal, Models, Genetic, Morphogenesis, Time Factors, Signal Transduction, Gene Expression Regulation, Developmental, Tissue Engineering, Organogenesis, Mammary Glands, Human
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