The DOI matches its Crossref record; 187 of the 189 references it cites were found in a registry or an index.
Sculpting Organs: Mechanical Regulation of Tissue Development
Abstract
The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Finally, it has become increasingly clear that the mechanical properties in three-dimensional (3D) culture systems can have large effects on cell51, organoid52, tissue53, and organ development54,55.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [53]
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,710
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182
Self-citationTensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S. A., Bershadsky, A. D., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,137
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 2,081
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Cells lying on a bed of microneedles: An approach to isolate mechanical force
Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235407100 · Cited by 2,002
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Burridge, K., & Chrzanowska‐Wodnicka, M. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.463 · Cited by 1,957
Geometric cues for directing the differentiation of mesenchymal stem cells
Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841
Nonlinear elasticity in biological gels
Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,707
Maniotis, A. J., Chen, C. S., & Ingber, D. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.849 · Cited by 1,630
Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton
Ren, X. D., Kiosses, W. B., & Schwartz, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.578 · Cited by 1,573
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Grashoff, C., Hoffman, B. D., Brenner, M. D., Zhou, R., Parsons, M., Yang, M. T., McLean, M. A., Sligar, S. G., Chen, C. S., Ha, T., et al. (2010) · Nature · doi:10.1038/nature09198 · Cited by 1,549
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science · doi:10.1126/science.277.5324.333 · Cited by 1,543
How does the extracellular matrix direct gene expression?
Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346
Physical forces during collective cell migration
Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E. J., Weitz, D. A., Butler, J. P., & Fredberg, J. J. (2009) · Nature Physics · doi:10.1038/nphys1269 · Cited by 1,198
Reconstruction of Tissues by Dissociated Cells
Steinberg, M. S. (1963) · Science · doi:10.1126/science.141.3579.401 · Cited by 1,127
Mechanical regulation of cell function with geometrically modulated elastomeric substrates
Fu, J., Wang, Y.-K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1487 · Cited by 1,073
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
Bertet, C., Sulak, L., & Lecuit, T. (2004) · Nature · doi:10.1038/nature02590 · Cited by 1,037
Deconstructing the Cadherin-Catenin-Actin Complex
Yamada, S., Pokutta, S., Drees, F., Weis, W. I., & Nelson, W. J. (2005) · Cell · doi:10.1016/j.cell.2005.09.020 · Cited by 1,022
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
Hove, J. R., Köster, R. W., Forouhar, A. S., Acevedo‐Bolton, G., Fraser, S. E., & Gharib, M. (2003) · Nature · doi:10.1038/nature01282 · Cited by 1,000
α-Catenin as a tension transducer that induces adherens junction development
Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A., & Shibata, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2055 · Cited by 972
Collective cell guidance by cooperative intercellular forces
Tambe, D. T., Hardin, C., Angelini, T. E., Rajendran, K., Park, C. Y., Serra‐Picamal, X., Zhou, E. H., Zaman, M. H., Butler, J. P., Weitz, D. A., et al. (2010) · Nature Materials · doi:10.1038/nmat3025 · Cited by 942
Min, H.-S., Danilenko, D., Scully, S., Bolon, B., Ring, B., Tarpley, J., Derose, M., & Simonet, W. (1998) · Genes & Development · doi:10.1101/gad.12.20.3156 · Cited by 928
The differential adhesion hypothesis: a direct evaluation
Foty, R. A., & Steinberg, M. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.012 · Cited by 908
Directed movements and selective adhesion of embryonic amphibian cells
Townes, P. L., & Holtfreter, J. (1955) · Journal of Experimental Zoology · doi:10.1002/jez.1401280105 · Cited by 872
Emergent patterns of growth controlled by multicellular form and mechanics
Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502575102 · Cited by 867
Self-citationMechanobiology and diseases of mechanotransduction
Ingber, D. E. (2003) · Annals of Medicine · doi:10.1080/07853890310016333 · Cited by 865
Moerlooze, L. D., Spencer‐Dene, B., Revest, J., Hajihosseini, M. K., Rosewell, I. R., & Dickson, C. (2000) · Development · doi:10.1242/dev.127.3.483 · Cited by 863
Mechanisms of Mechanotransduction
Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.006 · Cited by 838
Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium
Prætorius, H. A., & Spring, K. R. (2001) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0075-4 · Cited by 828
The extracellular matrix guides the orientation of the cell division axis
Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J., & Bornens, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1307 · Cited by 825
Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration
Evans, E. A., & Yeung, A. (1989) · Biophysical Journal · doi:10.1016/s0006-3495(89)82660-8 · Cited by 808
Tensile forces govern germ-layer organization in zebrafish
Krieg, M., Arboleda-Estudillo, Y., Puech, P., Käfer, J., Graner, F., Müller, D. J., & Heisenberg, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1705 · Cited by 804
The branching programme of mouse lung development
Metzger, R. J., Klein, O. D., Martin, G. R., & Krasnow, M. A. (2008) · Nature · doi:10.1038/nature07005 · Cited by 787
The PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 783
Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763
LEUNG, T. K. C., Manser, E. J., Tan, L. H.-P., & Lim, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29051 · Cited by 722
Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development
Costantini, F. D., & Kopan, R. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.04.008 · Cited by 719
Mechanical tugging force regulates the size of cell–cell junctions
Liu, Z., Tan, J. L., Cohen, D. M., Yang, M. T., Sniadecki, N. J., Ruiz, S. A., Nelson, C. M., & Chen, C. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914547107 · Cited by 704
Self-citationSingle stretch-activated ion channels in vascular endothelial cells as mechanotransducers?
Lansman, J. B., Hallam, T. J., & RINK, T. J. (1987) · Nature · doi:10.1038/325811a0 · Cited by 699
Integrins and Extracellular Matrix in Mechanotransduction
Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662
Lubarsky, B., & Krasnow, M. A. (2003) · Cell · doi:10.1016/s0092-8674(02)01283-7 · Cited by 660
le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D., & de Rooij, J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001149 · Cited by 652
Mechanical feedback as a possible regulator of tissue growth.
Shraiman, B. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0404782102 · Cited by 636
Rørth, P. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113231 · Cited by 625
Théry, M., Racine, V., Piel, M., Pépin, A., Dimitrov, A., Chen, Y., Sibarita, J., & Bornens, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609267103 · Cited by 623
Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis
Ewald, A. J., Brenot, A., Duong, M., Chan, B. S., & Werb, Z. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.003 · Cited by 620
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
Rauzi, M., Vérant, P., Lecuit, T., & Lenne, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1798 · Cited by 616
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 616
Self-citationZhong, C., Chrzanowska‐Wodnicka, M., Brown, J. A., Maddox, A. S., Belkin, A. M., & Burridge, K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.539 · Cited by 605
Steinberg, M. S., & Takeichi, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.206 · Cited by 572
Fibronectin requirement in branching morphogenesis
Sakai, T., Larsen, M., & Yamada, K. M. (2003) · Nature · doi:10.1038/nature01712 · Cited by 559
Patterned Gene Expression Directs Bipolar Planar Polarity in Drosophila
Zallen, J. A., & Wieschaus, E. F. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00060-7 · Cited by 556
Integration of contractile forces during tissue invagination
Martin, A. C., Gelbart, M., Fernandez-Gonzalez, R., Kaschube, M., & Wieschaus, E. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910099 · Cited by 545
Defective planar cell polarity in polycystic kidney disease
Fischer, E. A., Legué, E., Doyen, A., Nato, F., Nicolas, J.-F., Torres, V. E., Yaniv, M., & Pontoglio, M. (2005) · Nature Genetics · doi:10.1038/ng1701 · Cited by 534
Mechanisms of convergence and extension by cell intercalation
Keller, R. E., Davidson, L. A., Edlund, A., Elul, T., Ezin, M., Shook, D. R., & Skoglund, P. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0626 · Cited by 521
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
Weaver, M., Dunn, N. R., & Hogan, B. L. M. (2000) · Development · doi:10.1242/dev.127.12.2695 · Cited by 507
Apical constriction: A cell shape change that can drive morphogenesis
Sawyer, J. M., Harrell, J. R., Shemer, G., Sullivan-Brown, J., Roh‐Johnson, M., & Goldstein, B. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.009 · Cited by 458
Cell distribution of stress fibres in response to the geometry of the adhesive environment
Théry, M., Pépin, A., Dressaire, E., Chen, Y., & Bornens, M. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20126 · Cited by 452
Composition and Formation of Intercellular Junctions in Epithelial Cells
Knust, E., & Bossinger, O. (2002) · Science · doi:10.1126/science.1072161 · Cited by 436
The emergence of geometric order in proliferating metazoan epithelia
Gibson, M. C., Patel, A. B., Nagpal, R., & Perrimon, N. (2006) · Nature · doi:10.1038/nature05014 · Cited by 435
Warburton, D., El-Hashash, A. H. K., Carraro, G., Tiozzo, C., Sala, F., Rogers, O., Langhe, S. D., Kemp, P. J., Riccardi, D., Torday, J. S., et al. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)90003-3 · Cited by 431
A two-tiered mechanism for stabilization and immobilization of E-cadherin
Cavey, M., Rauzi, M., Lenne, P., & Lecuit, T. (2008) · Nature · doi:10.1038/nature06953 · Cited by 420
Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures
Ruiz, S. A., & Chen, C. S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0432 · Cited by 415
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Levin, M. G., Thorlin, T., Robinson, K. R., Nogi, T., & Mercola, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00939-x · Cited by 397
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J. (2009) · Nature Genetics · doi:10.1038/ng.400 · Cited by 391
Cell-Cell Mechanical Communication through Compliant Substrates
Reinhart‐King, C. A., Dembo, M., & Hammer, D. A. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.127662 · Cited by 391
Abe, K., & Takeichi, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710504105 · Cited by 378
On the mechanism of wing size determination in fly development
Hufnagel, L., Teleman, A. A., Rouault, H., Cohen, S. M., & Shraiman, B. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607134104 · Cited by 376
Regulation of lung expansion and lung growth before birth
Harding, R., & Hooper, S. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.209 · Cited by 373
Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin
Gao, L., McBeath, R., & Chen, C. S. (2010) · Stem Cells · doi:10.1002/stem.308 · Cited by 372
Surface mechanics mediate pattern formation in the developing retina
Hayashi, T., & Carthew, R. W. (2004) · Nature · doi:10.1038/nature02952 · Cited by 371
Samakovlis, C., Hacohen, N., Manning, G., Sutherland, D. C., Guillemin, K. J., & Krasnow, M. A. (1996) · Development · doi:10.1242/dev.122.5.1395 · Cited by 368
Sakakura, T., Nishizuka, Y., & Dawe, C. J. (1976) · Science · doi:10.1126/science.827022 · Cited by 357
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration
Andrew, D. J., & Ewald, A. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.024 · Cited by 352
Drosophila oocyte localization is mediated by differential cadherin-based adhesion
Godt, D., & Tepaß, U. (1998) · Nature · doi:10.1038/26493 · Cited by 349
The Orientation of Cell Divisions Determines the Shape of Drosophila Organs
Baena-López, L. A., Baonza, A., & Garcı́a-Bellido, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.062 · Cited by 332
Kratochwil, K. (1969) · Developmental Biology · doi:10.1016/0012-1606(69)90004-9 · Cited by 331
Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1
Klebe, C., Bischoff, F. R., Ponstingl, H., & Wittinghofer, A. (1995) · Biochemistry · doi:10.1021/bi00002a031 · Cited by 323
Sternlicht, M. D., Sunnarborg, S. W., Kouros‐Mehr, H., Yu, Y., Lee, D. C., & Werb, Z. (2005) · Development · doi:10.1242/dev.01966 · Cited by 322
Luschnig, S., Bätz, T., Armbruster, K., & Krasnow, M. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.11.072 · Cited by 318
Molecular Mechanisms Of Tubulogenesis
Hogan, B. L. M., & Kolodziej, P. A. (2002) · Nature Reviews Genetics · doi:10.1038/nrg840 · Cited by 317
Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development
Ciarloni, L., Mallepell, S., & Brisken, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611647104 · Cited by 316
FGF-10 Is a Chemotactic Factor for Distal Epithelial Buds during Lung Development
Park, W. Y., Miranda, B., Lebeche, D., Hashimoto, G., & Cardoso, W. V. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8994 · Cited by 312
Wnt5a Participates in Distal Lung Morphogenesis
Li, C., Xiao, J., Hormi, K., Borok, Z., & Minoo, P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0729 · Cited by 310
Wiseman, B. S., Sternlicht, M. D., Lund, L. R., Alexander, C. M., Mott, J., Bissell, M. J., Soloway, P. D., Itohara, S., & Werb, Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302090 · Cited by 301
Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation
Blanchard, G. B., Kabla, A., Schultz, N., Butler, L., Sanson, B., Gorfinkiel, N., Mahadevan, L., & Adams, R. J. (2009) · Nature Methods · doi:10.1038/nmeth.1327 · Cited by 301
Brodland, G. W. (2002) · Journal of Biomechanical Engineering · doi:10.1115/1.1449491 · Cited by 296
Cell Migration Driven by Cooperative Substrate Deformation Patterns
Angelini, T. E., Hannezo, É., Trepat, X., Fredberg, J. J., & Weitz, D. A. (2010) · Physical Review Letters · doi:10.1103/physrevlett.104.168104 · Cited by 290
Korman, N. J., Eyre, R. W., Klaus-Kovtun, V., & Stanley, J. R. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909073211002 · Cited by 272
Organogenesis of the Caenorhabditis elegans Intestine
Leung, B., Hermann, G. J., & Priess, J. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9471 · Cited by 271
Wiesen, J. F., Young, P., Werb, Z., & Cunha, G. R. (1999) · Development · doi:10.1242/dev.126.2.335 · Cited by 265
Pierce, D. F., Johnson, M. D., Matsui, Y., Robinson, S. D., Gold, L. I., Purchio, A. F., Daniel, C. W., Hogan, B. L. M., & Moses, H. L. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2308 · Cited by 264
Genetic control of single lumen formation in the zebrafish gut
Bagnat, M., Cheung, I. D., Mostov, K. E., & Stainier, D. Y. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1621 · Cited by 262
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis
Humphreys, R. C., Krajewska, M., Krnacik, S., Jæger, R., Weiher, H., Krajewski, S., Reed, J. C., & Rosen, J. M. (1996) · Development · doi:10.1242/dev.122.12.4013 · Cited by 262
An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos
Monier, B., Pélissier-Monier, A., Brand, A. H., & Sanson, B. (2009) · Nature Cell Biology · doi:10.1038/ncb2005 · Cited by 258
Moore, K. A., Polte, T., Huang, S., Shi, B., Alsberg, E., Sunday, M. E., & Ingber, D. E. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20237 · Cited by 258
Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate
Paszek, M. J., Boettiger, D. E., Weaver, V. M., & Hammer, D. A. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000604 · Cited by 257
Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling
Tamaríz, E., & Grinnell, F. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0291 · Cited by 253
Cell polarity triggered by cell-cell adhesion via E-cadherin
Desai, R. A., Gao, L., Raghavan, S., Liu, W. F., & Chen, C. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.028183 · Cited by 242
Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., San, I. V. L. C., Balda, M. S., & Matter, K. (2011) · Nature Cell Biology · doi:10.1038/ncb2156 · Cited by 238
Cell Mechanics Studied by a Reconstituted Model Tissue
Wakatsuki, T., Kolodney, M. S., Zahalak, G. I., & Elson, E. L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76481-2 · Cited by 236
Chi, X., Michos, O., Shakya, R., Riccio, P. N., Enomoto, H., Licht, J. D., Asai, N., Takahashi, M., Ohgami, N., Kato, M., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.013 · Cited by 234
Orchestrating size and shape during morphogenesis
Lecuit, T., & LeGoff, L. (2007) · Nature · doi:10.1038/nature06304 · Cited by 230
Lenzen, C. U., Cool, R. H., Prinz, H., Kuhlmann, J., & Wittinghofer, A. (1998) · Biochemistry · doi:10.1021/bi972621j · Cited by 227
Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch
Katsumi, A., Naoe, T., Matsushita, T., Kaibuchi, K., & Schwartz, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c400455200 · Cited by 225
Integrated morphodynamic signalling of the mammary gland
Gjorevski, N., & Nelson, C. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3168 · Cited by 224
Self-citationCell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis
Martín‐Belmonte, F., Yu, W., Rodriguez-Fraticelli, A., Ewald, A. J., Werb, Z., Alonso, M. A., & Mostov, K. E. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.076 · Cited by 224
Maternal β-catenin and E-cadherin in mouse development
de Vries, W. N., Evsikov, A. V., Haac, B. E., Fancher, K. S., Holbrook, A. E., Kemler, R., Solter, D., & Knowles, B. B. (2004) · Development · doi:10.1242/dev.01316 · Cited by 217
Harris, A. K. (1976) · Journal of Theoretical Biology · doi:10.1016/0022-5193(76)90019-9 · Cited by 215
Tissue geometry patterns epithelial–mesenchymal transition via intercellular mechanotransduction
Gomez, E. W., Chen, Q. K., Gjorevski, N., & Nelson, C. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22545 · Cited by 214
Self-citationEvidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
Mailleux, A., Tefft, D., Ndiaye‐Lobry, D., Itoh, N., Thiery, J. P., Warburton, D., & Bellusci, S. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00286-6 · Cited by 212
Cell and fibronectin dynamics during branching morphogenesis
Larsen, M., Wei, C., & Yamada, K. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03079 · Cited by 208
Zhou, J., Kim, H. Y., & Davidson, L. A. (2009) · Development · doi:10.1242/dev.026211 · Cited by 200
Developmental Regulation of Lung Liquid Transport
Olver, R. E., Walters, D. V., & Wilson, S. M. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.071702.145229 · Cited by 195
Embryonic origin and differentiation of the Drosophila heart
Rugendorff, A., Younossi‐Hartenstein, A., & Hartenstein, V. (1994) · Development Genes and Evolution · doi:10.1007/bf00360522 · Cited by 193
Collective Cell Migration Drives Morphogenesis of the Kidney Nephron
Vasilyev, A., Liu, Y., Mudumana, S. P., Mangos, S., Lam, P., Majumdar, Å., Zhao, J., Poon, K., Kondrychyn, I., Korzh, V. P., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.1000009 · Cited by 188
Tsarouhas, V., Senti, K.-A., Jayaram, S. A., Tiklová, K., Hemphälä, J., Adler, J., & Samakovlis, C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.06.008 · Cited by 186
Warburton, D., Seth, R., Shum, L., Horcher, P. G., Hall, F. L., Werb, Z., & Slavkin, H. C. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90269-m · Cited by 186
González‐Reyes, A., & Johnston, D. S. (1998) · Development · doi:10.1242/dev.125.15.2837 · Cited by 186
Guillemin, K. J., Groppe, J. C., Duecker, K., Treisman, R., Hafen, E., Affolter, M., & Krasnow, M. A. (1996) · Development · doi:10.1242/dev.122.5.1353 · Cited by 185
Nelson, C. M., Pirone, D. M., Tan, J. L., & Chen, C. S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0745 · Cited by 184
Self-citationJaźwińska, A., Ribeiro, C., & Affolter, M. (2003) · Nature Cell Biology · doi:10.1038/ncb1049 · Cited by 183
Levin, M. G., & Mercola, M. A. (1999) · Development · doi:10.1242/dev.126.21.4703 · Cited by 180
Roarty, K. P., & Serra, R. A. (2007) · Development · doi:10.1242/dev.008250 · Cited by 180
Renal branching morphogenesis: concepts, questions, and recent advances
Costantini, F. D. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00106.x · Cited by 180
Tonning, A., Hemphälä, J., Tång, E., Nannmark, U., Samakovlis, C., & Uv, A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.012 · Cited by 179
Control of Mitotic Spindle Angle by the RAS-Regulated ERK1/2 Pathway Determines Lung Tube Shape
Tang, N., Marshall, W., McMahon, M., Metzger, R. J., & Martin, G. (2011) · Science · doi:10.1126/science.1204831 · Cited by 175
Wnt5a regulates Shh and Fgf10 signaling during lung development
Li, C., Hu, L., Xiao, J., Chen, H., Li, J. T., Bellusci, S., Langhe, S. D., & Minoo, P. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.035 · Cited by 174
Collagen involvement in branching morphogenesis of embryonic lung and salivary gland
Spooner, B. S., & Faubion, J. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90458-3 · Cited by 172
Ramasamy, S., Mailleux, A., Gupte, V. V., Mata, F., Sala, F., Veltmaat, J., del Moral, P., Langhe, S. D., Parsa, S., Kelly, L. K., et al. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.033 · Cited by 172
Molliver, D. C., & Snider, W. D. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970519)381:4 · Cited by 171
Schittny, J. C., Miserocchi, G., & Sparrow, M. P. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.1.3926 · Cited by 158
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
Taguchi, K., Ishiuchi, T., & Takeichi, M. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201104124 · Cited by 157
Uitto, J., & Christiano, A. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115938 · Cited by 156
Horowitz, A., & Simons, M. (2008) · Circulation Research · doi:10.1161/circresaha.108.181818 · Cited by 155
Basson, M. A., Watson-Johnson, J., Shakya, R., Akbulut, S., Hyink, D. P., Costantini, F. D., Wilson, P. D., Mason, I. J., & Licht, J. D. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.051 · Cited by 154
Effects of collagenase on developing epithelia in vitro: Lung, ureteric bud, and pancreas
Wessells, N. K., & Cohen, J. H. (1968) · Developmental Biology · doi:10.1016/0012-1606(68)90037-7 · Cited by 150
Helmke, B. P., & Davies, P. F. (2002) · Annals of Biomedical Engineering · doi:10.1114/1.1467926 · Cited by 149
Pattern and regulation of cell proliferation during murine ureteric bud development
Michael, L., & Davies, J. A. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00285.x · Cited by 146
Fujisawa, K., Fujita, A., Ishizaki, T., Saito, Y., & Narumiya, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23022 · Cited by 143
Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland
Nakanishi, Y., Sugiura, F., Kishi, J., & Hayakawa, T. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90122-3 · Cited by 142
Do different branching epithelia use a conserved developmental mechanism?
Davies, J. A. (2002) · BioEssays · doi:10.1002/bies.10161 · Cited by 141
Self-Organization and Branching Morphogenesis of Primary Salivary Epithelial Cells
Wei, C., Larsen, M., Hoffman, M. P., & Yamada, K. M. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0123 · Cited by 139
Endogenous patterns of mechanical stress are required for branching morphogenesis
Gjorevski, N., & Nelson, C. M. (2010) · Integrative Biology · doi:10.1039/c0ib00040j · Cited by 137
Self-citationLiu, W. F., Nelson, C. M., Tan, J. L., & Chen, C. S. (2007) · Circulation Research · doi:10.1161/circresaha.107.158329 · Cited by 133
Self-citationModulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea
Shaye, D. D., Casanova, J., & Llimargas, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1756 · Cited by 124
The development in vitro of the submandibular and sublingual glands of Mus musculus.
Borghese, E. (1950) · PubMed · Cited by 122
mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins
Tefft, D., Lee, M., Smith, S. M., Crowe, D. L., Bellusci, S., & Warburton, D. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00372.2001 · Cited by 118
Force generated by actomyosin contraction builds bridges between adhesive contacts
Rossier, O., Gauthier, N. C., Biais, N., Vonnegut, W., Fardin, M.-A., Avigan, P., Heller, E., Mathur, A., Ghassemi, S., Koeckert, M. S., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.2 · Cited by 115
Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium
Matsuyama, M., Aizawa, S., & Shimono, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000427 · Cited by 108
Mechanics of head fold formation: investigating tissue-level forces during early development
Varner, V. D., Voronov, D. A., & Taber, L. A. (2010) · Development · doi:10.1242/dev.054387 · Cited by 98
Effect of tracheostomy on lung development in fetal lambs
Fewell, J. E., Hislop, A. A., Kitterman, J. A., & Johnson, P. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.4.1103 · Cited by 96
Zhang, H.-Z., Bennett, J. M., Smith, K. T., Sunil, N., & Haslam, S. Z. (2002) · Endocrinology · doi:10.1210/en.2002-220007 · Cited by 93
Unbekandt, M., del Moral, P.-M., Sala, F. G., Bellusci, S., Warburton, D., & Fleury, V. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.10.013 · Cited by 92
Myat, M. M., & Andrew, D. J. (2000) · Development · doi:10.1242/dev.127.4.679 · Cited by 91
Self-organization of engineered epithelial tubules by differential cellular motility
Mori, H., Gjorevski, N., Inman, J. L., Bissell, M. J., & Nelson, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901269106 · Cited by 88
Self-citationPolycystic kidney disease: Pathogenesis and potential therapies
Takiar, V., & Caplan, M. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.11.014 · Cited by 80
COPI Vesicle Transport Is a Common Requirement for Tube Expansion in Drosophila
Jayaram, S. A., Senti, K.-A., Tiklová, K., Tsarouhas, V., Hemphälä, J., & Samakovlis, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001964 · Cited by 77
Iwaki, D. D., Johansen, K. A., Singer, J. B., & Lengyel, J. A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0483 · Cited by 70
Developing Rat Lung Has a Sided Pacemaker Region for Morphogenesis-Related Airway Peristalsis
Jesudason, E. C., Smith, N. P., Connell, M. G., Spiller, D. G., White, M., Fernig, D. G., & Losty, P. D. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0304oc · Cited by 68
Wurst is essential for airway clearance and respiratory-tube size control
Behr, M., Wingen, C., Wolf, C., Schuh, R., & Hoch, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1611 · Cited by 66
Vascular stenosis: biology and interventions
Roy‐Chaudhury, P., & Lee, T. C. (2007) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3282efa57f · Cited by 64
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells
Chanson, L., Brownfield, D., Garbe, J. C., Kuhn, I., Stampfer, M. R., Bissell, M. J., & LaBarge, M. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019556108 · Cited by 63
Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude
Li, B., Li, F., Puskar, K. M., & Wang, J. H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.04.033 · Cited by 62
Fetal lung growth after tracheal ligation is not solely a pressure phenomenon
Papadakis, K. A., Luks, F. I., Paepe, M. E. D., Piasecki, G. J., & Wesselhoeft, C. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90208-6 · Cited by 59
Moore, K. A., Huang, S., Kong, Y., Sunday, M. E., & Ingber, D. E. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6418 · Cited by 57
Kanwar, Y. S., Ota, K., Yang, Q., Wada, J., Kashihara, N., Tian, Y., & Wallner, E. I. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.6.f934 · Cited by 57
Jesudason, E. C., Smith, N. P., Connell, M. G., Spiller, D. G., White, M., Fernig, D. G., & Losty, P. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00498.2005 · Cited by 56
Role of fetal breathing movements in control of fetal lung distension
Miller, A. A., Hooper, S. B., & Harding, R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.6.2711 · Cited by 55
A mechanism for early branching in lung morphogenesis
Lubkin, S. R., & Murray, J. D. (1995) · Journal of Mathematical Biology · doi:10.1007/bf00180137 · Cited by 54
Upper airway dynamics during breathing and during apnoea in fetal lambs.
Fewell, J. E., & Johnson, P. A. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014729 · Cited by 51
Cellular and Matrix Contributions to Tissue Construct Stiffness Increase with Cellular Concentration
Marquez, J. P., Genin, G. M., Pryse, K. M., & Elson, E. L. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9160-2 · Cited by 49
The human lung: did evolution get it wrong?
West, J. B., Watson, R. R., & Fu, Z. (2006) · European Respiratory Journal · doi:10.1183/09031936.00133306 · Cited by 48
Kostetskii, I., Yuan, S.-Y., Kostetskaia, E., Linask, K. K., Blanchet, S., Seleiro, E. A. P., Michaille, J., Brickell, P. M., & Zile, M. H. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199810)213:2 · Cited by 45
Seshaiah, P., Miller, B. R., Myat, M. M., & Andrew, D. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0429 · Cited by 45
Pavlovich, A. L., Boghaert, E., & Nelson, C. M. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.03.017 · Cited by 26
Self-citationOntogenetic changes in the fractal geometry of the bronchial tree in Rattus norvegicus
Canals, M., OLIVARES, R., Sprohnle, F. L., & Novoa, F. F. (2000) · Biological Research · doi:10.4067/s0716-97602000000100010 · Cited by 22
Research works printed but not linked: 3
- 10.1038/nature07005 · DOI
- Borghese E., 1950, J. Anat., 84, 287
- Kanwar YS, 1999, Am. J. Physiol., 277, F934
Cited by
Sorted by citations
Spatiotemporal hydrogel biomaterials for regenerative medicine
Brown, T. E., & Anseth, K. S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00445a · Cited by 436
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
In vivo quantification of spatially varying mechanical properties in developing tissues
Serwane, F., Mongera, A., Rowghanian, P., Kealhofer, D., Lucio, A. A., Hockenbery, Z. M., & Campàs, O. (2016) · Nature Methods · doi:10.1038/nmeth.4101 · Cited by 370
Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295
“The first human cell line – HeLa – was derived from the cervical adenoorgan microenvironment (Griffith and Swartz, 2006; Nelson and Gleghorn, 2011; Pexton et al., 2011).”
Human airway organoid engineering as a step toward lung regeneration and disease modeling
Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191
“Better understanding the morphogenetic function of YAP could facilitate advances in generating complex tissue engineered structures such as organoids, and given YAP's mechanoresponsive nature [53,56], our findings suggests that exogenous control of mechanical forces to better mimic the developmental environment may be…”
Background
Metadata
- Authors
- Nelson, C. M., & Gleghorn, J. P.
- Affiliations
- Princeton University (US)
- Department of Chemical and Biological Engineering and
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2012-08-15
- Volume
- 14
- Issue
- 1
- Pages
- 129-154
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2170979166
- Cited by
- 130
- References
- 189
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 3
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Susan G. Komen
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R21HL110335, HL110335)
- National Cancer Institute (CA128660, R21CA128660)
- National Institute of General Medical Sciences (R01GM083997, GM083997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- branching morphogenesis, organogenesis, cell contractility, mechanical regulation, mammary gland, lung development, epithelial sheets, microenvironment, tissue mechanics
- MeSH terms
- Animals, Biomedical Engineering, Humans, Lung, Mammary Glands, Animal, Models, Genetic, Morphogenesis, Time Factors, Signal Transduction, Gene Expression Regulation, Developmental, Tissue Engineering, Organogenesis, Mammary Glands, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review