The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Racemic Protein Crystallography
Abstract
Although natural proteins are chiral and are all of one “handedness,” their mirror image forms can be prepared by chemical synthesis. This opens up new opportunities for protein crystallography. A racemic mixture of the enantiomeric forms of a protein molecule can crystallize in ways that natural proteins cannot. Recent experimental data support a theoretical prediction that this should make racemic protein mixtures highly amenable to crystallization. Crystals obtained from racemic mixtures also offer advantages in structure determination strategies. The relevance of these potential advantages is heightened by advances in synthetic methods, which are extending the size limit for proteins that can be prepared by chemical synthesis. Recent ideas and results in the area of racemic protein crystallography are reviewed.
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Pentelute, B. L., Gates, Z. P., Dashnau, J. L., Vanderkooi, J. M., & Kent, S. B. H. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801352j · Cited by 77
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Cited by
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Chemical synthesis of proteins using peptide hydrazides as thioester surrogates
Zheng, J.-S., Tang, S., Qi, Y.-K., Wang, Z.-P., & Liu, L. (2013) · Nature Protocols · doi:10.1038/nprot.2013.152 · Cited by 537
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Auriemma, F., De Rosa, C., Di Caprio, M. R., Di Girolamo, R., Ellis, W. C., & Coates, G. W. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201410211 · Cited by 164
Synthesis and applications of mirror-image proteins
Harrison, K., Mackay, A. S., Kambanis, L., Maxwell, J. W. C., & Payne, R. J. (2023) · Nature Reviews Chemistry · doi:10.1038/s41570-023-00493-y · Cited by 104
Metadata
- Authors
- Yeates, T. O., & Kent, S. B. H.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2012-06-09
- Volume
- 41
- Issue
- 1
- Pages
- 41-61
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2016024115
- Cited by
- 163
- References
- 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
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