Cited by 190Protein Structure and DynamicsEvolution and Genetic DynamicsRNA and protein synthesis mechanisms

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The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution

Campitelli, Paul, Modi, Tushar, Kumar, Sudhir, Ozkan, S. Banu·2020·Annual Review of Biophysics

DOI 10.1146/annurev-biophys-052118-115517

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Abstract

Advances in sequencing techniques and statistical methods have made it possible not only to predict sequences of ancestral proteins but also to identify thousands of mutations in the human exome, some of which are disease associated. These developments have motivated numerous theories and raised many questions regarding the fundamental principles behind protein evolution, which have been traditionally investigated horizontally using the tip of the phylogenetic tree through comparative studies of extant proteins within a family. In this article, we review a vertical comparison of the modern and resurrected ancestral proteins. We focus mainly on the dynamical properties responsible for a protein's ability to adapt new functions in response to environmental changes. Using the Dynamic Flexibility Index and the Dynamic Coupling Index to quantify the relative flexibility and dynamic coupling at a site-specific, single-amino-acid level, we provide evidence that the migration of hinges, which are often functionally critical rigid sites, is a mechanism through which proteins can rapidly evolve. Additionally, we show that disease-associated mutations in proteins often result in flexibility changes even at positions distal from mutational sites, particularly in the modulation of active site dynamics.

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Authors: Campitelli, P., Modi, T., Kumar, S., & Ozkan, S. B.
Affiliations: Arizona State University (US)
King Abdulaziz University (SA)
ORCID: Campitelli, Paul
Modi, Tushar
Kumar, Sudhir
Ozkan, S. Banu
Venue: Annual Review of Biophysics
Publisher: Annual Reviews
Published: 2020-05-06
Volume: 49
Issue: 1
Pages: 267-288
ISSN: 1936-122X (ISSN-L)
1936-1238
DOI: 10.1146/annurev-biophys-052118-115517
OpenAlex: W3007324177
Cited by: 190
References: 112
Citations by year: 2026: 17 · 2025: 40 · 2024: 31 · 2023: 31 · 2022: 28 · 2021: 32 · 2020: 11
FWCI: 2.43
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: protein evolution, conformational dynamics, allosteric regulation, ancestral proteins, disease-associated mutations, active site dynamics, protein flexibility, functional adaptation
MeSH terms: Allosteric Regulation, Humans, Mutation, Protein Conformation, Proteins, Evolution, Molecular

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The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution

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