The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biophysics of Channelrhodopsin
Open accessAbstract
Channelrhodopsins (ChRs) are directly light-gated ion channels that function as sensory photoreceptors in flagellated green algae, allowing these algae to identify optimal light conditions for growth. In neuroscience, ChRs constitute the most versatile tools for the light-induced activation of selected cells or cell types with unprecedented precision in time and space. In recent years, many ChR variants have been discovered or engineered, and countless electrical and spectroscopic studies of these ChRs have been carried out, both in host cells and on purified recombinant proteins. With significant support from a high-resolution 3D structure and from molecular dynamics calculations, scientists are now able to develop models that conclusively explain ChR activation and ion conductance on the basis of chromophore isomerization, structural changes, proton transfer reactions, and water rearrangement on timescales ranging from femtoseconds to minutes.
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Cites
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Self-citationIndependent optical excitation of distinct neural populations
Klapoetke, N. C., Murata, Y., Kim, S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2836 · Cited by 2,344
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930
Cited by
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications
Govorunova, E. G., Sineshchekov, O. A., Li, H., & Spudich, J. L. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-101910-144233 · Cited by 363
Optogenetic Tools for Subcellular Applications in Neuroscience
Rost, B. R., Schneider-Warme, F., Schmitz, D., & Hegemann, P. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.047 · Cited by 317
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Metadata
- Authors
- Schneider, F., Grimm, C., & Hegemann, P.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2015-06-22
- Volume
- 44
- Issue
- 1
- Pages
- 167-186
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2111421954
- Cited by
- 192
- References
- 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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