The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
The Synaptic Vesicle Release Machinery
Abstract
Extensive research has yielded crucial insights into the mechanism of neurotransmitter release, and working models for the functions of key proteins involved in release. The SNAREs Syntaxin-1, Synaptobrevin, and SNAP-25 play a central role in membrane fusion, forming SNARE complexes that bridge the vesicle and plasma membranes and that are disassembled by NSF–SNAPs. Exocytosis likely starts with Syntaxin-1 folded into a self-inhibited closed conformation that binds to Munc18-1. Munc13s open Syntaxin-1, orchestrating SNARE complex assembly in an NSF–SNAP–resistant manner together with Munc18-1. In the resulting primed state, with partially assembled SNARE complexes, fusion is inhibited by Synaptotagmin-1 and Complexins, which also perform active functions in release. Upon influx of Ca 2+, Synaptotagmin-1 activates fast release, likely by relieving the inhibition caused by Complexins and cooperating with the SNAREs in bringing the membranes together. Although alternative models exist and fundamental questions remain unanswered, a definitive description of the basic release mechanism may be available soon.
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Cites
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Cited by
The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms
Chanaday, N. L., Cousin, M. A., Milosevic, I., Watanabe, S., & Morgan, J. R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1158-19.2019 · Cited by 255
Mechanism of neurotransmitter release coming into focus
Rizo, J. (2018) · Protein Science · doi:10.1002/pro.3445 · Cited by 210
Self-citationXu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y.-Z., Ma, C., Tomchick, D. R., Rosenmund, C., et al. (2017) · eLife · doi:10.7554/elife.22567 · Cited by 119
Self-citationNeuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Senatore, A., Reese, T. S., & Smith, C. L. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.162396 · Cited by 113
Recent advances in gene therapy for neurodevelopmental disorders with epilepsy
Turner, T. J., Zourray, C., Schorge, S., & Lignani, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15168 · Cited by 71
Metadata
- Authors
- Rizo, J., & Xu, J.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2015-06-22
- Volume
- 44
- Issue
- 1
- Pages
- 339-367
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2166747217
- Cited by
- 339
- References
- 185
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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