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Cited by 120Cellular Mechanics and InteractionsMicrotubule and mitosis dynamicsProtein Kinase Regulation and GTPase Signaling

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F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation

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Kadzik, Rachel S., Homa, Kaitlin E., Kovar, David R.·2020·Annual Review of Cell and Developmental Biology
DOI 10.1146/annurev-cellbio-032320-094706PMC PMC8675537
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Abstract

Many fundamental cellular processes such as division, polarization, endocytosis, and motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) networks at specific locations and times within the cell. The particular function of each network is governed by F-actin organization, size, and density as well as by its dynamics. The distinct characteristics of different F-actin networks are determined through the coordinated actions of specific sets of actin-binding proteins (ABPs). Furthermore, a cell typically assembles and uses multiple F-actin networks simultaneously within a common cytoplasm, so these networks must self-organize from a common pool of shared globular actin (G-actin) monomers and overlapping sets of ABPs. Recent advances in multicolor imaging and analysis of ABPs and their associated F-actin networks in cells, as well as the development of sophisticated in vitro reconstitutions of networks with ensembles of ABPs, have allowed the field to start uncovering the underlying principles by which cells self-organize diverse F-actin networks to execute basic cellular functions.

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  • The filamentous actin (F-actin) network must participate in the lumen formation of the 3D-reconstitution model at the right time and place with the right organization.

    “the filamentous actin (F-actin) network must participate in the lumen formation of the 3D-reconstitution model at the right time and place with the right organization.[17]”

    From Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids (2022) · cites this paper as [17]

    The “Self-organization and homeostasis in cell biology” section says F-actin networks must assemble and disassemble at the correct time and place with proper organization. It does not establish that F-actin is required for lumen formation in a 3D-reconstitution model; searches for lumen formation and 3D reconstitution found no supporting passage. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Metadata

Authors
Kadzik, R. S., Homa, K. E., & Kovar, D. R.
Affiliations
  • Northwestern University (US)
  • University of Chicago (US)
ORCID
Kovar, David R.
Venue
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Published
2020-10-06
Volume
36
Issue
1
Pages
35-60
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
DOI
10.1146/annurev-cellbio-032320-094706
PMC
PMC8675537
OpenAlex
W3092324095
Cited by
120
References
0
Citations by year
2026: 18 · 2025: 28 · 2024: 23 · 2023: 24 · 2022: 16 · 2021: 9 · 2020: 2
FWCI
1.48
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Defense (W911NF1410403)
  • National Institutes of Health (GM079265)
  • Multidisciplinary University Research Initiative (W911NF-14-1-0403)
  • National Institute of General Medical Sciences (R01GM079265)
  • Army Research Office (W911NF-14-1-0403)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
F-actin network, actin-binding proteins, actin dynamics, competition and cooperation, multicolor imaging, cell motility, cell division, cell polarization, endocytosis
MeSH terms
Actins, Animals, Humans, Microfilament Proteins, Actin Cytoskeleton, Models, Biological, Schizosaccharomyces

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