The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Transmembrane Signaling Proteoglycans
Abstract
Virtually all metazoan cells contain at least one and usually several types of transmembrane proteoglycans. These are varied in protein structure and type of polysaccharide, but the total number of vertebrate genes encoding transmembrane proteoglycan core proteins is less than 10. Some core proteins, including those of the syndecans, always possess covalently coupled glycosaminoglycans; others do not. Syndecan has a long evolutionary history, as it is present in invertebrates, but many other transmembrane proteoglycans are vertebrate inventions. The variety of proteins and their glycosaminoglycan chains is matched by diverse functions. However, all assume roles as coreceptors, often working alongside high-affinity growth factor receptors or adhesion receptors such as integrins. Other common themes are an ability to signal through their cytoplasmic domains, often to the actin cytoskeleton, and linkage to PDZ protein networks. Many transmembrane proteoglycans associate on the cell surface with metzincin proteases and can be shed by them. Work with model systems in vivo and in vitro reveals roles in growth, adhesion, migration, and metabolism. Furthermore, a wide range of phenotypes for the core proteins has been obtained in mouse knockout experiments. Here some of the latest developments in the field are examined in hopes of stimulating further interest in this fascinating group of molecules.
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Extracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
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Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
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Fibronectin Regulates Wnt7a Signaling and Satellite Cell Expansion
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Structure and Response to Flow of the Glycocalyx Layer
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Syndecans in cartilage breakdown and synovial inflammation
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Self-citationOver forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?
Azevedo, R., Peixoto, A., Gaiteiro, C., Fernandes, E., Neves, M., Lima, L., Santos, L. L., & Ferreira, J. A. (2017) · Oncotarget · doi:10.18632/oncotarget.19433 · Cited by 39
Metadata
- Authors
- Couchman, J. R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2010-11-10
- Volume
- 26
- Issue
- 1
- Pages
- 89-114
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2103048323
- Cited by
- 403
- References
- 7
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
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