The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Mucins and Their Role in Shaping the Functions of Mucus Barriers
Open accessAbstract
We review what is currently understood about how the structure of the primary solid component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical properties of mucus that are required for it to perform its diverse physiological roles. Macroscale processes such as lubrication require mucus of a certain stiffness and spinnability, which are set by structural features of the mucin network, including the identity and density of cross-links and the degree of glycosylation. At the microscale, these same features affect the mechanical environment experienced by small particles and play a crucial role in establishing an interaction-based filter. Finally, mucin glycans are critical for regulating microbial interactions, serving as receptor binding sites for adhesion, as nutrient sources, and as environmental signals. We conclude by discussing how these structural principles can be used in the design of synthetic mucin-mimetic materials and provide suggestions for directions of future work in this field.
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Cites
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Muc5b is required for airway defence
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Cited by
The extracellular matrix and the immune system: A mutually dependent relationship
Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519
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Mechanomicrobiology: how bacteria sense and respond to forces
Dufrêne, Y. F., & Persat, A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0314-2 · Cited by 299
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment
El Moukhtari, S. H., Rodríguez-Nogales, C., & Blanco-Prieto, M. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.004 · Cited by 70
Chongsaritsinsuk, J., Steigmeyer, A. D., Mahoney, K. E., Rosenfeld, M. A., Lucas, T. M., Smith, C. M., Li, A., Ince, D., Kearns, F. L., Battison, A. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41756-y · Cited by 52
Metadata
- Authors
- Wagner, C. E., Wheeler, K. M., & Ribbeck, K.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2018-10-06
- Volume
- 34
- Issue
- 1
- Pages
- 189-215
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2895500801
- Cited by
- 303
- References
- 11
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wagner, C. E., Wheeler, K. M., & Ribbeck, K. (2018). Mucins and Their Role in Shaping the Functions of Mucus Barriers. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-100617-062818
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
