The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Cardiac Regenerative Capacity and Mechanisms
Open accessAbstract
The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide vulnerable to heart failure each year. By contrast, certain other vertebrate species such as zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms and advances in methodology to transplant cells together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review focuses on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained.
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Cited by
Preparing the ground for tissue regeneration: from mechanism to therapy
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Meis1 regulates postnatal cardiomyocyte cell cycle arrest
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Bioactive polymeric scaffolds for tissue engineering
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Metadata
- Authors
- Kikuchi, K., & Poss, K. D.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2012-11-10
- Volume
- 28
- Issue
- 1
- Pages
- 719-741
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2105435666
- Cited by
- 289
- References
- 14
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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