Cited by 326Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessDigital Mental Health Interventions

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Prevention of Major Depression

Muñoz, Ricardo F., Cuijpers, Pim, Smit, Filip, Barrera, Alinne Z., Leykin, Yan·2010·Annual Review of Clinical Psychology

DOI 10.1146/annurev-clinpsy-033109-132040

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Abstract

Before the 1980s, no randomized controlled trials had been carried out to test whether major depressive episodes could be prevented. In the past 30 years, several trials have reported success in reducing the incidence (the number of new cases) of major depressive episodes. These studies suggest that major depression can be prevented. Given the large burden of disease caused by major depression, it is time for substantial systematic efforts to replicate these studies, carry out multisite trials, and widely disseminate prevention interventions found to be effective. The present review examines the conceptual and practical differences between treatment and prevention trials and the importance of identifying groups at high short-term risk for major depressive episodes to make prevention trials feasible. We also list the randomized controlled prevention trials that have been carried out to date and discuss the need for prevention interventions that go beyond the limits of traditional face-to-face interventions.

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Authors: Muñoz, R. F., Cuijpers, P., Smit, F., Barrera, A. Z., & Leykin, Y.
Affiliations: San Francisco General Hospital (US)
Amsterdam Public Health (NL)
Palo Alto University (US)
ORCID: Muñoz, Ricardo F.
Cuijpers, Pim
Smit, Filip
Barrera, Alinne Z.
Leykin, Yan
Venue: Annual Review of Clinical Psychology
Publisher: Annual Reviews
Published: 2010-03-01
Volume: 6
Issue: 1
Pages: 181-212
ISSN: 1548-5943 (ISSN-L)
1548-5951
DOI: 10.1146/annurev-clinpsy-033109-132040
OpenAlex: W2120806935
Cited by: 326
References: 163
Citations by year: 2026: 8 · 2025: 7 · 2024: 18 · 2023: 17 · 2022: 15 · 2021: 29 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 25 · 2014: 36 · 2013: 28 · 2012: 26
FWCI: 2.95
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: National Institute of Mental Health (T32MH019391, F32 MH07771)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Keywords: major depressive disorder, depression prevention, randomized controlled trials, prevention trials, treatment trials, high-risk groups, replication, multisite trials, intervention dissemination, face-to-face intervention
MeSH terms: Major Depressive Disorder, Health Promotion, Humans, Incidence, Prevalence

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