Major depression can be prevented.
Open accessAbstract
The 2009 Institute of Medicine report on prevention of mental, emotional, and behavioral disorders (National Research Council & Institute of Medicine, 2009b) presented evidence that major depression can be prevented. In this article, we highlight the implications of the report for public policy and research. Randomized controlled trials have shown that the incidence of major depressive episodes can be significantly reduced. Meta-analyses suggest that 22% to 38% of major depressive episodes could be prevented with currently available methods. We argue that if major depressive episodes can be prevented, the health care system should provide routine access to evidence-based depression prevention interventions, just as it provides inoculations for other common and debilitating health problems. At the same time, researchers should pursue the major directions advocated by the Institute of Medicine report to increase the enduring effectiveness of future prevention interventions. These directions include taking a developmental perspective, learning to identify groups at high risk, and testing evidence-based interventions that are likely to have the widest reach. Scientific evidence has shown that clinical depression can be averted. Our societies must take action to reduce clinical depression to the lowest possible level. This article is one of three in a special section (see also Biglan, Flay, Embry, & Sandler, 2012; Yoshikawa, Aber, & Beardslee, 2012) representing an elaboration on a theme for prevention science developed by the 2009 report of the National Research Council and Institute of Medicine.
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Past research with college students found adequate internal consistency for DASS depression, anxiety, and stress subscales with alphas of .87, .79, and .84.
“Past research with college students indicates adequate internal consistency with Cronbach’s alpha of .87, .79 and .84 for the depression, anxiety and stress subscales.38”
From Feasibility of a Prototype Web-Based Acceptance and Commitment Therapy Prevention Program for College Students. (2014) · cites this paper as [38]
The passages from the paper’s References section concern depression-prevention studies, not the DASS subscales. Searches for the DASS alpha values and for internal consistency in college students found no passage reporting the claimed values. (LLM, conf=0.76)
Experimental — accuracy not yet measuredIndicated prevention of depression or anxiety disorders in young people still represents a 'blind spot in health care' and has been less investigated than selective/universal approaches.
“Indicated prevention of depression or anxiety disorders in young people still represents a 'blind spot in health care' 108-110 and has been less investigated than selective/universal approaches 111 .”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [109]
Bullying victimization and parental psychological distress could be modified or prevented through interventions.
“Given that bullying victimization and parental psychological distress could be modified or prevented through interventions [17, 35]”
From Predictors of chronic loneliness during adolescence: a population-based cohort study (2022) · cites this paper as [35]
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- Authors
- Muñoz, R. F., Beardslee, W. R., & Leykin, Y.
- Affiliations
- San Francisco General Hospital (US)
- Boston Children's Hospital (US)
- University of California, San Francisco (US)
- Venue
- American Psychologist
- Published
- 2012-05
- Volume
- 67
- Issue
- 4
- Pages
- 285-295
- ISSN
- 0003-066X (ISSN-L)
- 1935-990X
- PMC
- PMC4533896
- OpenAlex
- W1985780857
- Cited by
- 174
- References
- 91
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 17 · 2023: 8 · 2022: 7 · 2021: 23 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 14 · 2016: 16 · 2015: 11 · 2014: 23 · 2013: 18 · 2012: 4
- FWCI
- 27.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Psychologist (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California Committee on Latino Research
- National Institutes of Health (R01MH37992, R21MH59605, R34MH091231, 5K08MH091501)
- Brin/Wojcicki Foundation
- Sidney R. Baer, Jr. Foundation
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, depression prevention, mental health prevention, evidence-based interventions, prevention science, public policy, developmental perspective, high-risk groups
- MeSH terms
- Depressive Disorder, Major, Major Depressive Disorder, Depressive Disorder, Health Policy, Health Promotion, Humans, Evidence-Based Medicine, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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