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Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
Open accessAbstract
The schizophrenia spectrum disorders are neurodevelopmental illnesses with a lifetime prevalence near 1%, producing extensive functional impairment and low expectations for recovery. Until recently, treatment in the United States has largely attempted to stabilize individuals with chronic schizophrenia. The identification and promotion of evidence-based practices for schizophrenia via the Patient Outcomes Research Team, combined with international studies supporting the value of early intervention, provided the foundation for the Recovery After an Initial Schizophrenia Episode (RAISE) project. The RAISE studies further supported the value of reducing the duration of untreated psychosis and providing a multi-element treatment called coordinated specialty care (CSC) to improve outcomes for patients in usual treatment settings. Although CSC programs have proliferated rapidly in the United States, many challenges remain in the treatment and recovery of individuals with schizophrenia in the aftermath of RAISE.
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“The ICD-11's shorter duration requirement, along with the introduction of a first-episode course qualifier (also introduced in the DSM-5), is intended to encourage earlier initiation of appropriate treatment, which has been shown to improve patient outcomes 38 .”
From An organization‐ and category‐level comparison of diagnostic requirements for mental disorders in ICD ‐11 and DSM ‐5 (2021) · cites this paper as [38]
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Self-citationEvolution of a maternal immune activation (mIA) model in rats: Early developmental effects
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Self-citationDisengagement From Early Intervention Services for Psychosis: A Systematic Review
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Self-citationCaregivers of individuals with schizophrenia
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Self-citationOnTrackNY’s learning healthcare system
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Predicting Child-to-Adult Community Mental Health Service Continuation
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“They are highly disabling, create substantial burdens for their families and communities [1–3], and cost the US more than $100 billion annually [4, 5].”
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“…has paved the way for emerging research on Coordinated Specialty Care (CSC) for recent onset of psychosis in young adults (Bello et al., 2017; Dixon et al., 2018; SAMHSA, 2018), results suggest a need for applying emerging research beyond the recent onset of psychosis and inclusive of young…”
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“applyparastyle "fig//caption/p[1]" parastyle "FigCapt" applyparastyle "fig" parastyle "Figure"”
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“An artifact of community mental health care creation in the 1960s, akin to most states in the U.S., the Texas adult public mental health system focuses on treating those “disabled” by serious and persistent mental illnesses (Dixon et al., 2018; Grob, 1994, Grob & Goldman, 2006).”
BackgroundViolence risk assessment for young adults receiving treatment for early psychosis
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“The promise of CSC for promoting the recovery of individuals developing schizophrenia-related disorders has led to the expansion of federal funding for CSC programs through the federal community mental health block grant program (1).”
BackgroundSelf-citationTaking the next step: Improving care transitions from a first‐episode psychosis service
Gallagher, K. E., Ferrara, M., Pollard, J., Sykes, L. Y., Li, F., Imetovski, S., Cahill, J. D., Mathis, W. S., & Srihari, V. H. (2021) · Early Intervention in Psychiatry · doi:10.1111/eip.13127 · Cited by 9
“Consistent with the coordinated specialty care (CSC) model, STEP offers a multicomponent, individualized treatment package (Dixon et al., 2018) (Srihari et al., 2015).”
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“The extensive literature on CSC programs includes research related to pathways to care, service use, and treatment outcomes (2).”
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“One large-scale study called the Recovery After an Initial Schizophrenia Episode (RAISE) project aimed to promote coordinated specialty care to reduce the duration of untreated psychosis after an initial episode [72,73] and showed positive results [74,75].”
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“Specialty team-based clinical services (termed Coordinated Specialty Care or CSC in the US) for early course schizophrenia spectrum disorders have raised expectations for functional recovery [10].”
Self-citationMALLA, A. K., Roy, M., Abdel‐Baki, A., Conus, P., & McGorry, P. D. (2021) · Santé mentale au Québec · doi:10.7202/1088190ar · Cited by 6
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“Schizophrenia is a debilitating chronic condition affecting approximately 1% of the US population (Dixon et al., 2018).”
BackgroundRolin, S. A., Caffrey, D., Flores, M. G., Mootz, J. J., Bello, I., Nossel, I. R., Compton, M. T., Stanley, B., Wainberg, M. L., Dixon, L. B., et al. (2024) · Community Mental Health Journal · doi:10.1007/s10597-024-01343-x · Cited by 5
“…development of specialized early intervention services (EIS) for young people soon after the emergence of psychotic symptoms, has led to improvements in outcomes, such as improved quality of life, higher engagement in treatment and fewer hospitalizations (Dixon, 2018; Lieberman, 2013; Kane, 2016).”
Self-citationDigital health for early psychosis in Ghana: patient and caregiver needs and preferences
Larsen, A., Agorinya, J., Beaulieu, A., Sottie, E. Q., Buck, B., Obeng, K. M., Kyeremeh, B., Dogbe, F. K., Iddrisu, M. I., Dowuona, P. E. O., et al. (2025) · Schizophrenia · doi:10.1038/s41537-025-00554-9 · Cited by 4
“These are key target populations for intervention; individuals with early psychosis stand to bene fi t from early treatments that could greatly impact the lifelong trajectory of their illness 8,9,31 .”
Ghose, S. S., George, P., Goldman, H. H., Ren, W., Zhu, X., Dixon, L. B., & Rosenblatt, A. (2023) · Psychiatric Services · doi:10.1176/appi.ps.20220112 · Cited by 4
Self-citationFekih‐Romdhane, F., Hallit, S. R., Cheour, M., & Jahrami, H. (2023) · Springer eBooks · doi:10.1007/978-3-031-31547-3_45 · Cited by 3
Moe, A. M., Cowan, H. R., Manges, M. E., Wastler, H. M., Hamilton, S. A., Kilicoglu, M. F. V., Holmes, A. C., & Breitborde, N. J. K. (2024) · Early Intervention in Psychiatry · doi:10.1111/eip.13590 · Cited by 4
“Rapid access to specialized intervention following psychosis onset leads to not only symptomatic reduction, but significant improvements in quality of life and functional outcomes (Dixon et al., 2018; Fusar-Poli et al., 2017).”
InfluentialSykes, L. Y., Levine, N., Tayfur, S. N., Gibbs-Dean, T., Hazan, H., Imetovski, S., James, J., Karmani, S., Mathis, W. S., Markovich, P. J., et al. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.03.029 · Cited by 4
Self-citationKlodnick, V. V., Brenits, A., Johnson, R. P., Cohen, D. A., Paauw, M. A., Zeidner, E., & Fagan, M. A. (2023) · Evaluation and Program Planning · doi:10.1016/j.evalprogplan.2023.102268 · Cited by 4
Rolin, S. A., Caffrey, D., Flores, M. G., Pope, L. G., Mootz, J. J., Bello, I., Nossel, I. R., Compton, M. T., Stanley, B., Wainberg, M. L., et al. (2024) · Early Intervention in Psychiatry · doi:10.1111/eip.13543 · Cited by 5
“Early intervention services (EIS) for young people with early psychosis have been associated with improved outcomes, including improved quality of life, higher participation in work/school, fewer hospitalizations and reduced symptoms (Dixon et al., 2018).”
Self-citationStructural Characteristics of Early Psychosis Intervention Network (EPINET) Programs
George, P., Spark, T. L., Devora, A., Mukai, R., Cosgrove, J. A., Goldman, H. H., & Rosenblatt, A. (2026) · Psychiatric Services · doi:10.1176/appi.ps.20250320 · Cited by 3
Self-citationThe Recovery Model and Other Rehabilitative Approaches
Ragins, M., & Sunkel, C. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_157 · Cited by 3
Bargagli, A. M., Cascini, S., Forastiere, A., Calandrini, E., Cesaroni, G., Marino, C., Davoli, M., & Agabiti, N. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06151-x · Cited by 3
“For example, early intervention in mental healthcare services to provide multidisciplinary care for people with emerging psychosis is needed as undertreatment is associated with poorer health and social outcomes [1, 2].”
BackgroundCalkins, M. E., Jumper, M. B. E., Ered, A., Dong, F., Sarpal, D. K., Baker, K. K., Bencivengo, D. J., Margolis, R. L., Buchanan, R. W., Boumaiz, Y., et al. (2025) · Early Intervention in Psychiatry · doi:10.1111/eip.70031 · Cited by 3
Service Use Following First-Episode Schizophrenia Among Commercially Insured Youth
Gilmer, T., van der Ven, E., Susser, E., Dixon, L. B., & Olfson, M. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz031 · Cited by 3
Self-citationGetting in Early: Early Intervention Services for Psychosis
Gates, J., & Killackey, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815012-2.00024-9 · Cited by 3
Klodnick, V. V., Johnson, R. P., Cohen, D. A., Fagan, M. A., Fetzer, P., & Clark, H. B. “. (2022) · Social Work in Mental Health · doi:10.1080/15332985.2022.2118007 · Cited by 3
“More so than ever before do AYA with a recent onset of psychosis have access to evidence-based care models proven to decrease psychosis symptoms and improve quality of life (e.g., Dixon et al., 2018; Kane et al., 2016).”
BackgroundWhat Explains Changes in Availability of Specialty Mental Health Services in Organized Settings?
Newton, H., Humensky, J. L., Goldman, H. H., & Busch, S. H. (2022) · Milbank Quarterly · doi:10.1111/1468-0009.12592 · Cited by 3
Self-citationThe Recovery Model and Other Rehabilitative Approaches
Ragins, M., & Sunkel, C. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_157-1 · Cited by 3
The Challenge of Nonadherence in Schizophrenia
Lawrence, R. E., & Dixon, L. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-12665-0_4 · Cited by 3
Self-citationEarly interventions for psychosis
Goldman, M. B. (2021) · Current Psychiatry · doi:10.12788/cp.0176 · Cited by 3
Learning health systems for first-episode psychosis: Insights from North America
Srihari, V. H., & Keshavan, M. S. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.10.025 · Cited by 2
Self-citationA systematic review of psychosis in social work literature
Chaudhry, S., Roy, R. J., Weiss, A. L., & Hansel, T. C. (2022) · Social Work in Mental Health · doi:10.1080/15332985.2022.2029667 · Cited by 2
Ghose, S. S., George, P., Goldman, H. H., Daley, T. C., Dixon, L. B., Ren, W., Zhu, X., & Rosenblatt, A. (2022) · Psychiatric Services · doi:10.1176/appi.ps.202100676 · Cited by 2
Self-citationSchizophrenia and Psychosis: Treatment and Follow-Up
Thompson, E. C., Meinhardt, N., & McClellan, J. (2024) · Issues in clinical child psychology · doi:10.1007/978-3-031-62749-1_15 · Cited by 2
Bello, I., Stefančić, A., Florence, A. C., Wall, M. M., Radigan, M., Malinovsky, I., Nossel, I. R., Mathai, C. M., Cabassa, L. J., Fidaleo, K., et al. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.03.033 · Cited by 2
Self-citationThe EnTRy Program: Expanding Coordinated Specialty Care Beyond Early Psychosis
Fried, J., McQuistion, H. L., Marrelli, J., Hampton, M. C., Wu, L., LeGeros, A. R., Lanina, O., & Frankle, W. G. (2025) · Community Mental Health Journal · doi:10.1007/s10597-025-01491-8 · Cited by 2
“This led to a proliferation of funding granted specifically to early intervention programs, such as OnTrackNY in New York State and the Early Assess - ment and Support Alliance (EASA) in Oregon (Dixon et al., 2018), and by 2018 there were 244 CSC programs in the United States dedicated to first break psychosis (George…”
School-Based Approaches in Youth with Psychosis
Hines, S., & Coman, D. C. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.08.014 · Cited by 2
Schizophrenia or Other Primary Psychotic Disorders
Gäebel, W., & Salveridou‐Hof, E. (2023) · Cambridge University Press eBooks · doi:10.1017/9781009182232.004 · Cited by 2
Intervensi Social Skills Training Pada Pasien Skizofrenia: Reviu Literatur
H, S. H. S., & Mustikasari, M. (2023) · Health Information Jurnal Penelitian · doi:10.36990/hijp.v15i3.1151 · Cited by 1
Psychotic Experiences Questionnaire. Part 2
Анатольевна, С. О., Truevtsev, D. V., & Zhirnova, O. V. (2024) · Neurology Bulletin · doi:10.17816/nb632357 · Cited by 1
Johnson, R. P., LaPelusa, B., Mayhue, A., Schneider, A., Crowe, A. N., Diggins, T., Brown, A., Spencer, E., Cohen, D. A., & Klodnick, V. V. (2024) · Community Mental Health Journal · doi:10.1007/s10597-024-01431-y · Cited by 1
“Employment is developmentally normative for TAY (Dixon et al., 2018), and is a social determinant of health (Drake & Wallach, 2020).”
Dixon, L. B., & Goldman, H. H. (2022) · Community Mental Health Journal · doi:10.1007/s10597-022-00960-8 · Cited by 1
Self-citationFekih‐Romdhane, F., Hallit, S. R., Cheour, M., & Jahrami, H. (2022) · Springer eBooks · doi:10.1007/978-3-030-98711-4_45-1 · Cited by 1
Early Psychosis and the Prevention and Mitigation of Serious Mental Illness
Bello, I., Nossel, I. R., & Dixon, L. B. (2022) · Springer eBooks · doi:10.1007/978-3-031-10239-4_43 · Cited by 1
Self-citationWastler, H. M., Llamocca, E. N., Moe, A. M., Steelsmith, D. L., Brock, G. N., Bridge, J. A., Campo, J. V., & Fontanella, C. A. (2023) · Psychiatric Services · doi:10.1176/appi.ps.20220372 · Cited by 1
Psicose e drogas: estado mental de risco e primeiro episódio psicótico em usuários de maconha
Moreira, E. C. (2022) · EDUFBA eBooks · doi:10.7476/9786556305059 · Cited by 1
Oluwoye, O., Lissau, A., Stokes, S. D., Selloni, A. T., James, N., Amiri, S., McDonell, M. G., & Anglin, D. M. (2023) · Implementation Science Communications · doi:10.1186/s43058-023-00476-6 · Cited by 1
Kopelovich, S. L., Straub, K. T., Vaswani-Bye, A., Brian, R., & Monroe‐DeVita, M. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2024.12.011 · Cited by 1
Building a two-state learning healthcare system for persons with first episode psychosis
Marsteller, J. A., Goldberg, R. W., Boumaiz, Y., Jumper, M. B. E., Taylor, J., Saravana, A., Buchanan, R. W., Chengappa, K. N. R., Conroy, C. G., Dickerson, F., et al. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.02.004 · Cited by 1
Early Intervention in Psychosis: From Science to Services
Smith, T. E., & Dixon, L. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-11908-9_11 · Cited by 1
Self-citationGoldman, H. H. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12823
Self-citationSuryaputra, D., & Adik, W. (2019) · Strengthening Hospital Competitiveness to Improve Patient Satisfaction and Better Health Outcomes · doi:10.26911/the6thicph-fp.04.10
“3 Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative Dixon et al. (2018), USA - The Recovery After an Initial Schizophreni a Episode (RAISE) project - multi-element treatment called coordinated specialty care (CSC) - Evidence is mounting for the positive impact of CSC on a range of…”
InfluentialStacy, M. A., & Davidson, C. A. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108951760.006
Implementing Evidence-Based Psychosocial Interventions for Psychosis
Glenthøj, L. B., Jankowski, S. E., Dixon, L. B., & Nordentoft, M. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108951760.008
Self-citationMeasuring Success in First Episode Psychosis
McKinley, E. (2022) · doi:10.15760/honors.1268
Metadata
- Authors
- Dixon, L. B., Goldman, H. H., Srihari, V. H., & Kane, J. M.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Maryland, Baltimore (US)
- Yale University (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2018-05-07
- Volume
- 14
- Issue
- 1
- Pages
- 237-258
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC8990328
- OpenAlex
- W2782714767
- Cited by
- 112
- References
- 110
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 13 · 2020: 9 · 2019: 15 · 2018: 6
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (RC1MH088971, R01MH120597)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, coordinated specialty care, early intervention, duration of untreated psychosis, schizophrenia spectrum disorders, recovery, evidence-based practice, functional disability
- MeSH terms
- Humans, Mental Health Services, Psychotic Disorders, Schizophrenia, United States, Program Development, Evidence-Based Practice
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