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Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
Open accessAbstract
The schizophrenia spectrum disorders are neurodevelopmental illnesses with a lifetime prevalence near 1%, producing extensive functional impairment and low expectations for recovery. Until recently, treatment in the United States has largely attempted to stabilize individuals with chronic schizophrenia. The identification and promotion of evidence-based practices for schizophrenia via the Patient Outcomes Research Team, combined with international studies supporting the value of early intervention, provided the foundation for the Recovery After an Initial Schizophrenia Episode (RAISE) project. The RAISE studies further supported the value of reducing the duration of untreated psychosis and providing a multi-element treatment called coordinated specialty care (CSC) to improve outcomes for patients in usual treatment settings. Although CSC programs have proliferated rapidly in the United States, many challenges remain in the treatment and recovery of individuals with schizophrenia in the aftermath of RAISE.
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“The ICD-11's shorter duration requirement, along with the introduction of a first-episode course qualifier (also introduced in the DSM-5), is intended to encourage earlier initiation of appropriate treatment, which has been shown to improve patient outcomes 38 .”
From An organization‐ and category‐level comparison of diagnostic requirements for mental disorders in ICD ‐11 and DSM ‐5 (2021) · cites this paper as [38]
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“ACKNOWLEDGMENTS The authors would like to acknowledge Robert Heinssen and Susan Azrin of the National Institute of Mental Health and the RAISE-ETP, RAISE-IES, and STEP study teams.”
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Dixon, L. B., Dickerson, F., Bellack, A. S., Bennett, M., Dickinson, D., Goldberg, R. W., Lehman, A., Tenhula, W. N., Calmes, C., Pasillas, R. M., et al. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp115 · Cited by 774 · cited 2×
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Lehman, A. F., Kreyenbuhl, J. A., Buchanan, R. W., Dickerson, F., Dixon, L. B., Goldberg, R., Green-Paden, L. D., Tenhula, W. N., Boerescu, D. A., Tek, C., et al. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007071 · Cited by 754 · cited 2×
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Lehman, A. F., Steinwachs, D. M., & The Survey Co-Investigators of the PORT Project (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033303 · Cited by 594 · cited 3×
“In the first set of PORT recommendations (Lehman & Steinwachs 1998a), 18 of the 30 recommendations focused on the use of antipsychotic medications for acute and maintenance treatment.”
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Kreyenbuhl, J., Buchanan, R. W., Dickerson, F. B., & Dixon, L. B. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp130 · Cited by 499
Self-citationThe Economic Burden of Schizophrenia in the United States in 2013
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Correll, C. U., Robinson, D. G., Schooler, N. R., Brunette, M. F., Mueser, K. T., Rosenheck, R. A., Marcy, P., Addington, J., Estroff, S. E., Robinson, J., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1314 · Cited by 384 · cited 1×
“With regard to medical status (Correll et al. 2014), in 394 of 404 patients with cardiometabolic data [mean (SD) age = 23.6 (5.0) years; mean (SD) lifetime antipsychotic treatment = 47.3 (46.1) days], 48.3% were obese or overweight, 50.8% smoked, 56.5% had dyslipidemia, 39.9% had pre-hypertension,…”
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“Three of the five papers came from a UK longitudinal study named the Study of Cognitive Reality Alignment Therapy in Early Schizophrenia (SoCRATES) (Lewis et al. 2002, Tarrier & Wykes 2004, Tarrier et al. 2006).”
BackgroundLong-Term Follow-Up of the TIPS Early Detection in Psychosis Study: Effects on 10-Year Outcome
Hegelstad, W. T. V., Larsen, T. K., Auestad, B., Evensen, J. H., Haahr, U., Joa, I., Johannesen, J. O., Langeveld, J., Melle, I. S., Opjordsmoen, S., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030459 · Cited by 317 · cited 1×
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“Three of the five papers came from a UK longitudinal study named the Study of Cognitive Reality Alignment Therapy in Early Schizophrenia (SoCRATES) (Lewis et al. 2002, Tarrier & Wykes 2004, Tarrier et al. 2006).”
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“Five of the studies came from the OPUS project in Denmark (Bertelsen et al. 2008; Jeppesen et al. 2005; Kassow et al. 2002; Petersen et al. 2005a,b), two came from the Lambeth Early Onset (LEO) project in the United Kingdom (Craig et al. 2004, Garety et al. 2006), and one came from a small RCT in…”
BackgroundKillackey, E. J., Jackson, H. J., & McGorry, P. D. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.043109 · Cited by 299 · cited 1×
“This study evaluated an occupational intervention for early psychosis (Killackey et al. 2008).”
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“These unacceptable delays to care occur during periods of highest risk for self-harm and aggression (Nielssen & Large 2010, Pompili et al. 2011), but they more commonly cause avoidable suffering for the affected youth and their families as they traverse chaotic and disorganized pathways to care.”
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“Seventeen clinics were randomized to deliver NAVIGATE and 17 clinics were randomized to provide usual care.”
MethodInfluentialSelf-citationImplementing Early Intervention in Psychosis: A Guide to Establishing Psychosis Services
Edwards, J., & McGorry, P. D. (2002) · doi:10.1201/b14315 · Cited by 226
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“The second controlled study, which took place in the Netherlands, found no differences between individuals receiving the family intervention and individuals not receiving it (Linszen et al. 1996).”
Fluphenazine vs Placebo in Patients With Remitted, Acute First-Episode Schizophrenia
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Self-citationFusar‐Poli, P., Yung, A. R., McGorry, P. D., & van Os, J. (2013) · Psychological Medicine · doi:10.1017/s0033291713000184 · Cited by 219 · cited 1×
“[Notably, ongoing and interleaved research efforts have focused on identifying those at risk and testing approaches to prevent the onset of psychosis (Fusar-Poli et al. 2012, 2014), but consideration of that important task is beyond the scope of this review.]”
BackgroundSpecialised care for early psychosis: Symptoms, social functioning and patient satisfaction
Garety, P. A., Craig, T., Dunn, G., Fornells‐Ambrojo, M., Colbert, S., Rahaman, N., Reed, J., & Power, P. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.104.007286 · Cited by 219 · cited 1×
“…the OPUS project in Denmark (Bertelsen et al. 2008; Jeppesen et al. 2005; Kassow et al. 2002; Petersen et al. 2005a,b), two came from the Lambeth Early Onset (LEO) project in the United Kingdom (Craig et al. 2004, Garety et al. 2006), and one came from a small RCT in Norway (Grawe et al. 2006).”
BackgroundSchizophrenia--Time to Commit to Policy Change
Fleischhacker, W. W., Arango, C., Arteel, P., Barnes, T. R. E., Carpenter, W., Duckworth, K., Galderisi, S., Halpern, L., Knapp, M., Marder, S. R., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu006 · Cited by 214 · cited 1×
“…adding to the similar conclusions of the international literature on societal economic benefit (Alison et al. 2012) and strengthening consensus on the need for policy commitments to support further implementation and refinement of models of care (Fleischhacker et al. 2014, Lieberman et al. 2013).”
BackgroundA systematic review and meta-analysis of cognitive remediation in early schizophrenia
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“To name a few, problems with cognition (Revell et al. 2015), substance use (Seddon et al. 2016), and suicidality (Coentre et al. 2017) require further attention.”
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“Adherence estimator scores (McHorney 2009) decreased (fewer beliefs associated with nonadherence) with NAVIGATE but not clinician-choice care.”
BackgroundImplementing Coordinated Specialty Care for Early Psychosis: The RAISE Connection Program
Dixon, L. B., Goldman, H. H., Bennett, M. E., Wang, Y., McNamara, K. A., Mendon, S. J., Goldstein, A. B., Choi, C.-W. J., Lee, R. J., Lieberman, J. A., et al. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400281 · Cited by 190 · cited 2×
“Participants had reduced symptoms and improved social and occupational functioning over time (Dixon et al. 2015).”
BackgroundSelf-citationTek, C., Küçükgöncü, S., Gülöksüz, S., Woods, S. W., Srihari, V. H., & Annamalai, A. (2015) · Early Intervention in Psychiatry · doi:10.1111/eip.12251 · Cited by 187 · cited 1×
“Specific approaches include smoking prevention and cessation, counseling and lifestyle modification to prevent or limit weight gain, preferred use of lower-risk antipsychotics (Tek et al. 2015), routine monitoring, and referral to and coordination of access to appropriate medical care.”
BackgroundSelf-citationSuicide risk in first episode psychosis: A selective review of the current literature
Pompili, M., Serafini, G., Innamorati, M., Lester, D., Shrivastava, A., Girardi, P., & Nordentoft, M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.008 · Cited by 182
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“Only 10–15% of people with schizophrenia are employed, and many remain on disability (Harvey et al. 2012).”
BackgroundMedicaid And Mental Health: Be Careful What You Ask For
Frank, R. G., Goldman, H. H., & Hogan, M. F. (2003) · Health Affairs · doi:10.1377/hlthaff.22.1.101 · Cited by 175 · cited 1×
“The lack of public sector priority for individuals in the early stages of psychosis was exacerbated by the fact that the system increasingly relied on Medicaid for funding (Frank et al. 2003).”
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Effect of early intervention on 5-year outcome in non-affective psychosis
Gafoor, R., Nitsch, D., McCrone, P., Craig, T., Garety, P. A., Power, P., & McGuire, P. K. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.066050 · Cited by 168 · cited 2×
“Follow-up studies of several CSC RCTs to date, including OPUS and LEO, suggest that the benefits observed at the time of program completion are not sustained 5 and 10 years later (Bertelsen et al. 2008, Gafoor et al. 2010, Secher et al. 2015, Sigrúnarson et al. 2013).”
BackgroundPragmatic randomised controlled trials in psychiatry
Hotopf, M., Churchill, R., & Lewis, G. (1999) · British Journal of Psychiatry · doi:10.1192/bjp.175.3.217 · Cited by 165 · cited 1×
“This project was advanced by a series of pragmatic randomized trials that retained the experimental benefit of minimizing selection bias (via randomization) while also allowing for more realistic samples, interventions, and patient-oriented outcome measures (Hotopf et al. 1999).”
BackgroundImproving 1-year outcome in first-episode psychosis
Petersen, L., Nordentoft, M., Jeppesen, P., ⊘hlenschlæger, J., Thorup, A. A. E., Christensen, T. Ø., Krarup, G., Dahlstr⊘m, J., Haastrup, B., & J⊘rgensen, P. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.48.s98 · Cited by 162
The Chronically Mentally Ill: Assessing Community Support Programs.
Grusky, O., Tessler, R. C., & Goldman, H. H. (1983) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2068685 · Cited by 162
Self-citationThe RAISE Early Treatment Program for First-Episode Psychosis
Kane, J. M., Schooler, N. R., Marcy, P., Correll, C. U., Brunette, M. F., Mueser, K. T., Rosenheck, R. A., Addington, J., Estroff, S. E., Robinson, J. A., et al. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09289 · Cited by 160 · cited 1×
“A total of 404 firstepisode psychosis patients with a mean age of 23 were enrolled (Kane et al. 2015).”
BackgroundSelf-citationSecher, R. G., Hjorthoj, C. R., Austin, S. F., Thorup, A., Jeppesen, P., Mors, O., & Nordentoft, M. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu155 · Cited by 158 · cited 1×
“Follow-up studies of several CSC RCTs to date, including OPUS and LEO, suggest that the benefits observed at the time of program completion are not sustained 5 and 10 years later (Bertelsen et al. 2008, Gafoor et al. 2010, Secher et al. 2015, Sigrúnarson et al. 2013).”
BackgroundJackson, H. J., McGorry, P. D., Killackey, E. J., Bendall, S., Allott, K., Dudgeon, P., Gleeson, J., Johnson, T., & Harrigan, S. (2007) · Psychological Medicine · doi:10.1017/s0033291707002061 · Cited by 149 · cited 1×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Again, this study found no significant differences between the CBT and comparison groups (Jackson et al. 2008).”
BackgroundInitiatives to shorten duration of untreated psychosis: systematic review
Lloyd‐Evans, B., Crosby, M., Stockton, S., Pilling, S., Hobbs, L. J., Hinton, M., & Johnson, S. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.075622 · Cited by 149 · cited 1×
“Multiple attempts across the world to reduce DUP provide a wealth of lessons and some notable successful examples (Lloyd-Evans et al. 2011).”
BackgroundRandomised-Control Trial of Family Intervention for 78 First-Episode Male Schizophrenic Patients
Zhang, M., Wang, M., Li, J., & Phillips, M. R. (1994) · The British Journal of Psychiatry · doi:10.1192/s0007125000293045 · Cited by 147
Integrated treatment of first-episode psychosis: effect of treatment on family burden
Jeppesen, P., Petersen, L., Thorup, A. A. E., Abel, M.-B., ⊘ehlenschlæger, J., Christensen, T. Ø., Krarup, G., Hemmingsen, R., J⊘rgensen, P., & Nordentoft, M. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.48.s85 · Cited by 142 · cited 1×
“Five of the studies came from the OPUS project in Denmark (Bertelsen et al. 2008; Jeppesen et al. 2005; Kassow et al. 2002; Petersen et al. 2005a,b), two came from the Lambeth Early Onset (LEO) project in the United Kingdom (Craig et al. 2004, Garety et al. 2006), and one came from a small RCT in…”
BackgroundRosenheck, R. A., LESLIE, D. L., Sint, K., Lin, H., Robinson, D. G., Schooler, N. R., Mueser, K. T., Penn, D. L., Addington, J., Brunette, M. F., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv224 · Cited by 141 · cited 3×
“Health economic analysis also indicated that overall the intervention was cost effective (Rosenheck et al. 2016).”
BackgroundMethodResultSelf-citationSrihari, V. H., Tek, C., Küçükgöncü, S., Phutane, V. H., Breitborde, N. J. K., Pollard, J., Özkan, B., Saksa, J. R., Walsh, B. C., & Woods, S. W. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400236 · Cited by 140 · cited 1×
“This trial demonstrated the effectiveness of CSC in a real-world US setting (Srihari et al. 2015), a finding that was further elaborated by the RAISE-ETP (Kane et al. 2016).”
MethodSelf-citationPharmacological Treatments for First-Episode Schizophrenia
Robinson, D. G. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi032 · Cited by 133 · cited 2×
“Additional studies confirmed the efficacy of antipsychotic medications in reducing the risk of relapse following a first episode of psychosis (Robinson et al. 2005).”
BackgroundResultTwo years of continued early treatment for recent‐onset schizophrenia: a randomised controlled study
Gråwe, R. W., Falloon, I. R. H., Widen, J. H., & Skogvoll, E. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00799.x · Cited by 124
Duration of Untreated Psychosis in Community Treatment Settings in the United States.
Addington, J., Heinssen, R., Robinson, D., Schooler, N., Marcy, P., Brunette, M. F., Correll, C., Estroff, S., Mueser, K., Penn, D., et al. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400124 · Cited by 121
Self-citationSeddon, J. L., Birchwood, M. J., Copello, A. G., Everard, L., Jones, P. B., Fowler, D. G., Amos, T., Freemantle, N., Sharma, V. K., Marshall, M., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv154 · Cited by 116 · cited 1×
“To name a few, problems with cognition (Revell et al. 2015), substance use (Seddon et al. 2016), and suicidality (Coentre et al. 2017) require further attention.”
BackgroundSymptom and functional outcomes for a 5year early intervention program for psychoses
Norman, R. M. G., Manchanda, R., MALLA, A. K., Windell, D., Harricharan, R., & Northcott, S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.04.006 · Cited by 113 · cited 1×
“The Prevention and Early Intervention Program for Psychoses in Ontario provided extended continuity of lower-intensity care for three additional years after the two-year standard CSC program (Norman et al. 2011).”
BackgroundRobinson, D. G., Gallego, J. A., John, M., Petrides, G., Hassoun, Y., Zhang, J., Lopez, L. V., Braga, R. J., Sevy, S. M., Addington, J., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv125 · Cited by 112
Self-citationAlbert, N., Melau, M., Jensen, H., Emborg, C., Jepsen, J. R. M., Fagerlund, B., Gluud, C. N., Mors, O. N., Hjorthøj, C. R., & Nordentoft, M. (2017) · BMJ · doi:10.1136/bmj.i6681 · Cited by 109
Social Functioning and the Course of Early-Onset Schizophrenia
Lenior, M. E., Dingemans, P. M. A. J., LINSZEN, D. H., de Haan, L., & Schene, A. H. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.1.53 · Cited by 105 · cited 1×
“In the follow-up study, five years later, individuals who had received the family intervention had spent less time living in institutional settings (Lenior et al. 2001, 2002).”
BackgroundBello, I., Lee, R., Malinovsky, I., Watkins, L. T., Nossel, I. R., Smith, T. E., Ngo, H., Birnbaum, M. L., Marino, L. A., Sederer, L. I., et al. (2016) · Psychiatric Services · doi:10.1176/appi.ps.201600512 · Cited by 102
Self-citationRosenheck, R. A., Mueser, K. T., Sint, K., Lin, H., Lynde, D., Glynn, S. M., Robinson, D. G., Schooler, N. R., Marcy, P., Mohamed, S., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.09.024 · Cited by 102
Self-citationReducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari, V. H., Tek, C., Pollard, J., Zimmet, S. V., Keat, J., Cahill, J. D., Küçükgöncü, S., Walsh, B. C., Li, F., Gueorguieva, R. V., et al. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0335-3 · Cited by 99 · cited 5×
“Effect of an early detection programme on duration of untreated psychosis: part of the Scandinavian TIPS study.”
BackgroundInfluentialSelf-citationThe Dilemma of Federal Mental Health Policy: Radical Reform or Incremental Change?
Provost, S. E. (2007) · Psychiatric Services · doi:10.1176/appi.ps.58.6.881-a · Cited by 94
Robinson, D. G., Schooler, N. R., John, M., Correll, C. U., Marcy, P., Addington, J., Brunette, M. F., Estroff, S. E., Mueser, K. T., Penn, D. L., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101355 · Cited by 93
Self-citationFirst Presentation With Psychotic Symptoms in a Population-Based Sample
Simon, G. E., Coleman, K. J., Yarborough, B. J. H., Operskalski, B. H., Stewart, C. C., Hunkeler, E. M., Lynch, F. W., Carrell, D., & Beck, A. L. (2017) · Psychiatric Services · doi:10.1176/appi.ps.201600257 · Cited by 93
Suicide behaviour over 18 months in recent onset schizophrenic patients: The effects of CBT
Tarrier, N., Haddock, G., Lewis, S., Drake, R., & Gregg, L. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.12.846 · Cited by 88 · cited 1×
“Three of the five papers came from a UK longitudinal study named the Study of Cognitive Reality Alignment Therapy in Early Schizophrenia (SoCRATES) (Lewis et al. 2002, Tarrier & Wykes 2004, Tarrier et al. 2006).”
BackgroundIs Early Intervention for Psychosis Feasible and Effective?
Srihari, V. H., Shah, J. L., & Keshavan, M. S. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.06.004 · Cited by 87 · cited 4×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript well-resourced care (clinician:patient ratios of 1:10 to 1:12), and established the efficacy of comprehensive specialty care services for early psychosis (Srihari et al. 2012).”
BackgroundInfluentialSelf-citationCoentre, R. M., Talina, M. C., Góis, C., & Figueira, M. L. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.04.010 · Cited by 87 · cited 1×
“To name a few, problems with cognition (Revell et al. 2015), substance use (Seddon et al. 2016), and suicidality (Coentre et al. 2017) require further attention.”
BackgroundSchoenbaum, M., Sutherland, J. M., Chappel, A. R., Azrin, S. T., Goldstein, A. B., Rupp, A. E., & HEINSSEN, R. K. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx009 · Cited by 82 · cited 1×
“The stakes are high, with mounting morbidity, premature mortality (Pompili et al. 2011, Schoenbaum et al. 2017), and economic costs (Alison et al. 2012) that only partially measure the true human costs of delayed and inadequate care.”
BackgroundChang, W. C., Chan, G. H. K., Jim, O. T. T., Lau, E. S. K., Hui, C. L. M., Chan, S. K. W., Lee, E. H. M., & Chen, E. Y. H. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.150144 · Cited by 82 · cited 2×
“Chang et al. (2015, 2017) performed an RCT in Hong Kong that compared individuals who had a one-year extension of the two-year CSC program called EASY to individuals who got stepped-down care.”
BackgroundAlvarez-Jimenez, M., O’Donoghue, B., Thompson, A., Gleeson, J. F., Bendall, S., Gonzalez-Blanch, C., Killackey, E., Wunderink, L., & McGorry, P. D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0331-x · Cited by 80
The Mad Among Us: A History of the Care of America's Mentally Ill.
Brown, J. V., Grob, G. M., & Trent, J. W. (1995) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2077415 · Cited by 73
Robinson, D. G., Schooler, N. R., Correll, C. U., John, M., Kurian, B. T., Marcy, P., Miller, A. L., Pipes, R., Trivedi, M. H., & Kane, J. M. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16080919 · Cited by 73
Self-citationEarly Detection and Intervention in Schizophrenia
Lieberman, J. A., Dixon, L. B., & Goldman, H. H. (2013) · JAMA · doi:10.1001/jama.2013.8804 · Cited by 69 · cited 2×
“…adding to the similar conclusions of the international literature on societal economic benefit (Alison et al. 2012) and strengthening consensus on the need for policy commitments to support further implementation and refinement of models of care (Fleischhacker et al. 2014, Lieberman et al. 2013).”
BackgroundSelf-citationLenior, M. E., Dingemans, P. M. A. J., Schene, A. H., Hart, A. A. M., & LINSZEN, D. H. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00305-x · Cited by 67 · cited 1×
“In the follow-up study, five years later, individuals who had received the family intervention had spent less time living in institutional settings (Lenior et al. 2001, 2002).”
BackgroundJackson, H. J., McGorry, P. D., EDWARDS, J., Hulbert, C. A., Henry, L. P., Harrigan, S., Dudgeon, P., Francey, S. M., Maude, D., Cocks, J., et al. (2005) · Psychological Medicine · doi:10.1017/s0033291705004927 · Cited by 64 · cited 1×
“The fourth CBT paper reported on a quasi-experimental study conducted in Australia and found no differences between the CBT intervention group and standard care (Jackson et al. 2005).”
BackgroundClient Views of Engagement in the RAISE Connection Program for Early Psychosis Recovery
Lucksted, A. A., Essock, S. M., Stevenson, J., Mendon, S. J., Nossel, I. R., Goldman, H. H., Goldstein, A. B., & Dixon, L. B. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400475 · Cited by 60 · cited 3×
“RAISE-IES also conducted two qualitative sub-studies focusing on engagement of clients and family members (Lucksted et al. 2015, 2017).”
BackgroundMethodSelf-citationCardiovascular mortality in schizophrenia: Defining a critical period for prevention
Srihari, V. H., Phutane, V. H., Özkan, B., Chwastiak, L., Ratliff, J. C., Woods, S. W., & Tek, C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.014 · Cited by 58 · cited 1×
“Given that these risk factors become even more pronounced in chronic psychosis populations, CSC providers are presented with an opportunity to engage in prevention of cardiovascular morbidity and mortality (Srihari et al. 2013).”
BackgroundSelf-citationCompton, M. T., Gordon, T. L., Goulding, S. M., Esterberg, M. L., Carter, T., Leiner, A. S., Weiss, P., Druss, B. G., Walker, E. F., & Kaslow, N. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05704yel · Cited by 57 · cited 1×
“Individuals with new-onset psychosis and their families face unnecessary suffering: delays to care are inordinately long (Addington et al. 2015, Compton et al. 2011), and best-practice services are not routinely available (Dixon 2017a).”
BackgroundDixon, L. B. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2665 · Cited by 53
Self-citationDevelopment and Testing of the First-Episode Psychosis Services Fidelity Scale
Addington, D. E., Norman, R. M. G., Bond, G. R., Sale, T. G., Melton, R. P., McKenzie, E., & Wang, J. (2016) · Psychiatric Services · doi:10.1176/appi.ps.201500398 · Cited by 53
Golay, P., Alameda, L., Baumann, P., Elowe, J., Progin, P., Polari, A. R., & Conus, P. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.017 · Cited by 50 · cited 1×
“DUP varies widely across the many early psychosis studies, which differ in inclusion criteria as well as definitions and assessment strategies for DUP, making cross-study comparisons difficult (Golay et al. 2016).”
BackgroundEffect of an early detection programme on duration of untreated psychosis
Friis, S., Vaglum, P., Haahr, U., Johannessen, J. O., Larsen, T. K., Melle, I. S., Opjordsmoen, S., Rund, B. J. R., Simonsen, E. H., & McGlashan, T. H. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.48.s29 · Cited by 50
Effective Interventions in schizophrenia: the economic case.
Andrew, A., Knapp, M. R. J., McCrone, P., Parsonage, M., & Trachtenberg, M. (2012) · London School of Economics and Political Science Research Online (London School of Economics and Political Science) · Cited by 46
Chang, W. C., Kwong, V. W. Y., Lau, E. S. K., So, H., Wong, C. S. M., Chan, G. H. K., Jim, O. T. T., Hui, C. L. M., Chan, S. K. W., Lee, E. H. M., et al. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.117.198929 · Cited by 45 · cited 2×
“Chang et al. (2015, 2017) performed an RCT in Hong Kong that compared individuals who had a one-year extension of the two-year CSC program called EASY to individuals who got stepped-down care.”
BackgroundFulford, D., Piškulić, D., Addington, J., Kane, J. M., Schooler, N. R., & Mueser, K. T. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx096 · Cited by 44 · cited 1×
“This suggests that improving occupational functioning in this population may benefit from targeting patient motivation directly (e.g., through motivational interviewing) or indirectly (e.g., by improving relationships and support networks) (Fulford et al. 2017).”
BackgroundSelf-citationEssock, S. M., Nossel, I. R., McNamara, K., Bennett, M. E., Buchanan, R. W., Kreyenbuhl, J. A., Mendon, S. J., Goldman, H. H., & Dixon, L. B. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400531 · Cited by 38 · cited 2×
“RAISE-IES also showed it was possible to sustain a long-term program by collaborating with state mental health authorities to fund CSC services (Essock et al. 2015a).”
BackgroundMethodSelf-citationThe RAISE Connection Program for Early Psychosis
Marino, L. A., Nossel, I. R., Choi, J. C., Nuechterlein, K. H., Wang, Y., Essock, S. M., Bennett, M. E., McNamara, K., Mendon, S. J., & Dixon, L. B. (2015) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000293 · Cited by 37 · cited 1×
“…global assessment of functioning; treatment fidelity, engagement, and family involvement were found to be mediators of improvement in occupational and social functioning; and processing speed was identified as a significant moderator of improvement in occupational functioning (Marino et al. 2015).”
BackgroundSelf-citationFamily member engagement with early psychosis specialty care
Lucksted, A. A., Stevenson, J., Nossel, I. R., Drapalski, A. L., Piscitelli, S., & Dixon, L. B. (2016) · Early Intervention in Psychiatry · doi:10.1111/eip.12403 · Cited by 35 · cited 3×
“Family members also shared their own challenges to engagement, which included personal responsibilities, lack of time and resources, and balancing the autonomy of their loved one with providing care and support (Lucksted et al. 2017).”
BackgroundMethodSelf-citationSigrúnarson, V., Gråwe, R. W., & Morken, G. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-200 · Cited by 34
Economic Grand Rounds: Financing First-Episode Psychosis Services in the United States
Goldman, H. H., Karakus, M. C., Frey, W. D., & Beronio, K. K. (2013) · Psychiatric Services · doi:10.1176/appi.ps.201300106 · Cited by 34
Self-citationIncomes and Outcomes: Social Security Disability Benefits in First-Episode Psychosis
Rosenheck, R. A., Estroff, S. E., Sint, K., Lin, H., Mueser, K. T., Robinson, D. G., Schooler, N. R., Marcy, P., Kane, J. M., & for the RAISE-ETP Investigators (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16111273 · Cited by 34
Self-citationSrihari, V. H., Breitborde, N. J. K., Pollard, J., Tek, C., Hyman, L., Frisman, L. K., McGlashan, T. H., Jacobs, S., & Woods, S. W. (2009) · Psychiatric Services · doi:10.1176/appi.ps.60.11.1426 · Cited by 30 · cited 1×
“…et al. 2012), San Francisco’s PREP (2006; http://felton.org/social-services/early-psychosisschizophreniaprep/), and Connecticut’s Specialized Treatment Early in Psychosis (STEP) program, which launched the first US pragmatic RCT of team-based care for early psychosis (2006; Srihari et al. 2009).”
BackgroundSelf-citationFirst-Episode Psychosis in the Criminal Justice System
Ford, E. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000066 · Cited by 30 · cited 1×
“Other strategies will need to reach into jails and prisons as well as schools and other community structures to identify and engage youth who are experiencing the onset of psychosis (Ford 2015).”
BackgroundEvaluation of a multi-element treatment center for early psychosis in the United States
Uzenoff, S. R., Penn, D. L., Graham, K. A., Saade, S., Smith, B. B., & Perkins, D. O. (2012) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-011-0467-4 · Cited by 29 · cited 1×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript (2003; Caplan et al. 2013), North Carolina’s OASIS (2005; Uzenoff et al. 2012), San Francisco’s PREP (2006; http://felton.org/social-services/early-psychosisschizophreniaprep/), and Connecticut’s Specialized Treatment…”
BackgroundEarly Intervention for Psychosis: The Recovery After an Initial Schizophrenia Episode Project
Azrin, S. T., Goldstein, A. B., & HEINSSEN, R. K. (2015) · Psychiatric Annals · doi:10.3928/00485713-20151103-05 · Cited by 27
Caplan, B., Zimmet, S. V., Meyer, E. C., Friedman‐Yakoobian, M. S., Monteleone, T., Leung, Y. J., Guyer, M. E., Rood, L. L., Keshavan, M. S., & Seidman, L. J. (2013) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.10.009 · Cited by 25
McGorry, P. D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr185 · Cited by 24 · cited 1×
“…providing care after the onset of psychosis is consistent with approaches to other medical disorders, and it presented itself as a “best bet” for many national health care systems that invested in this opportunity even as research and testing of specific models were still underway (McGorry 2012).”
MethodProlonged duration of untreated psychosis: a problem that needs addressing
Cotter, J., Zabel, E., French, P., & Yung, A. R. (2016) · Early Intervention in Psychiatry · doi:10.1111/eip.12308 · Cited by 21 · cited 1×
“Three months is a commonly accepted DUP target (Cotter et al. 2017) but the fact that CSC was compiled from treatment known to be effective in chronic schizophrenia suggests such team based, specialty care models may benefit patients later in the illness course.”
BackgroundPerceived Autonomy Support in the NIMH RAISE Early Treatment Program
Browne, J., Penn, D. L., Bauer, D. J., Meyer-Kalos, P., Mueser, K. T., Robinson, D. G., Addington, J., Schooler, N. R., Glynn, S. M., Gingerich, S. L., et al. (2017) · Psychiatric Services · doi:10.1176/appi.ps.201600480 · Cited by 21
Self-citationState Partnerships for First-Episode Psychosis Services
Essock, S. M., Goldman, H. H., Hogan, M. F., Hepburn, B. M., Sederer, L. I., & Dixon, L. B. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400117 · Cited by 20
Self-citationHumensky, J. L., Dixon, L. B., & Essock, S. M. (2013) · Psychiatric Services · doi:10.1176/appi.ps.201300186 · Cited by 20 · cited 1×
“…devised practical strategies to monitor treatment fidelity (Essock et al. 2015b), created an online interactive tool to estimate costs and resources for early psychosis care across a population (Humensky et al. 2013), and outlined approaches to financing the CSC program (Frank et al. 2015).”
MethodSelf-citationHumensky, J. L., Essock, S. M., & Dixon, L. B. (2017) · Psychiatric Rehabilitation Journal · doi:10.1037/prj0000256 · Cited by 19 · cited 1×
“Almost all participants (N = 59) met with the supported employment and education specialist at least three times (Humensky et al. 2017).”
BackgroundSelf-citationMental health economics: current methodological issues
McCrone, P. (2011) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796011000485 · Cited by 19 · cited 1×
“Whereas composite measures such as QALY allow comparisons across medical conditions, these may not be adequately sensitive to meaningful changes in the state of individuals with psychotic illnesses (McCrone 2011).”
BackgroundPaying for Early Interventions in Psychoses: A Three-Part Model
Frank, R. G., Glied, S., & McGuire, T. G. (2014) · Psychiatric Services · doi:10.1176/appi.ps.201400076 · Cited by 16 · cited 1×
“…devised practical strategies to monitor treatment fidelity (Essock et al. 2015b), created an online interactive tool to estimate costs and resources for early psychosis care across a population (Humensky et al. 2013), and outlined approaches to financing the CSC program (Frank et al. 2015).”
MethodWill Health Insurance Reform in the United States Help People With Schizophrenia?
Goldman, H. H. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq082 · Cited by 15
Self-citationDo Not Turn Out the Lights on the Public Mental Health System When the ACA is Fully Implemented
Goldman, H. H., & Karakus, M. C. (2014) · The Journal of Behavioral Health Services & Research · doi:10.1007/s11414-014-9394-y · Cited by 13 · cited 1×
“Furthermore, supplements to the federal block grant specifically earmarked for early intervention made more services available (Goldman & Karakus 2014).”
BackgroundSelf-citation178.2 Developing Strategies to Reduce DUP in the Age of Social Media and the Internet
Kane, J. M., & Birnbaum, M. L. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx021.254 · Cited by 3
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The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
Tandon, R., Nasrallah, H. A., Akbarian, S., Carpenter, W. T., DeLisi, L. E., Gäebel, W., Green, M. F., Gur, R. E., Heckers, S., Kane, J. M., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.11.015 · Cited by 205
Self-citationEvolution of a maternal immune activation (mIA) model in rats: Early developmental effects
Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M., Mason, V., Grayson, B., McHugh, P., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.005 · Cited by 91
“More recently, numerous states in the USA have also begun clinical as well as research pathways focused on early intervention (Dixon et al. 2018), albeit current pharmacological interventions are still not being developed within this staged approach (Marwaha et al.”
Results of a Coordinated Specialty Care Program for Early Psychosis and Predictors of Outcomes
Nossel, I. R., Wall, M. M., Scodes, J. M., Marino, L. A., Zilkha, S., Bello, I., Malinovsky, I., Lee, R., Radigan, M., Smith, T. E., et al. (2018) · Psychiatric Services · doi:10.1176/appi.ps.201700436 · Cited by 84
Self-citationDisengagement From Early Intervention Services for Psychosis: A Systematic Review
Mascayano, F., van der Ven, E., Martínez‐Alés, G., Restrepo, A., Zambrano, J., Jones, N., Cabassa, L. J., Smith, T. E., Yang, L. H., Susser, E., et al. (2020) · Psychiatric Services · doi:10.1176/appi.ps.201900375 · Cited by 81
Self-citation
Metadata
- Authors
- Dixon, L. B., Goldman, H. H., Srihari, V. H., & Kane, J. M.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Maryland, Baltimore (US)
- Yale University (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2018-05-07
- Volume
- 14
- Issue
- 1
- Pages
- 237-258
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC8990328
- OpenAlex
- W2782714767
- Cited by
- 112
- References
- 110
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 13 · 2020: 9 · 2019: 15 · 2018: 6
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (RC1MH088971, R01MH120597)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, coordinated specialty care, early intervention, duration of untreated psychosis, schizophrenia spectrum disorders, recovery, evidence-based practice, functional disability
- MeSH terms
- Humans, Mental Health Services, Psychotic Disorders, Schizophrenia, United States, Program Development, Evidence-Based Practice
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