The DOI matches its Crossref record, with a small difference in title or year; 218 of the 218 references it cites were found in a registry or an index.
The Fluid Mechanics of Cancer and Its Therapy
Abstract
Fluid mechanics is involved in the growth, progression, metastasis, and therapy of cancer. Blood vessels transport oxygen and nutrients to cancerous tissues, provide a route for metastasizing cancer cells to distant organs, and deliver drugs to tumors. The irregular and leaky tumor vasculature is responsible for increased interstitial pressure in the tumor microenvironment, whereas multiscale flow-structure interaction processes control tumor growth, metastasis, and nanoparticle-mediated drug delivery. We outline these flow-mediated processes, along with related experimental and computational methods for the diagnosis, predictive modeling, and therapy of cancer.
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“In contrast to normal tissue, in which lymphatic vessels maintain fluid balance and facilitate macromolecule clearance, tumors exhibit deficient lymphatic drainage, leading to elevated IFP [149,150].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [150]
Citations
Cites
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Cited by
Sorted by citations
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,145
The Role of Mechanical Forces in Tumor Growth and Therapy
Jain, R. K., Martin, J. D., & Stylianopoulos, T. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105259 · Cited by 1,044
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Fluids and their mechanics in tumour transit: shaping metastasis
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Numerical Simulation of Flowing Blood Cells
Freund, J. B. (2013) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-010313-141349 · Cited by 326
Metadata
- Authors
- Koumoutsakos, P., Pivkin, I., & Milde, F.
- Affiliations
- ETH Zurich (CH)
- Università della Svizzera italiana (CH)
- Venue
- Annual Review of Fluid Mechanics
- Publisher
- Annual Reviews
- Published
- 2013-01-03
- Volume
- 45
- Issue
- 1
- Pages
- 325-355
- ISSN
- 0066-4189 (ISSN-L)
- 1545-4479
- OpenAlex
- W2096404892
- Cited by
- 129
- References
- 218
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 10 · 2018: 20 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Fluid Mechanics (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor vasculature, tumor microenvironment, metastasis, nanoparticle drug delivery, tumor growth, cancer therapy
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