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The Fluid Mechanics of Cancer and Its Therapy
Abstract
Fluid mechanics is involved in the growth, progression, metastasis, and therapy of cancer. Blood vessels transport oxygen and nutrients to cancerous tissues, provide a route for metastasizing cancer cells to distant organs, and deliver drugs to tumors. The irregular and leaky tumor vasculature is responsible for increased interstitial pressure in the tumor microenvironment, whereas multiscale flow-structure interaction processes control tumor growth, metastasis, and nanoparticle-mediated drug delivery. We outline these flow-mediated processes, along with related experimental and computational methods for the diagnosis, predictive modeling, and therapy of cancer.
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“In contrast to normal tissue, in which lymphatic vessels maintain fluid balance and facilitate macromolecule clearance, tumors exhibit deficient lymphatic drainage, leading to elevated IFP [149,150].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [150]
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Metadata
- Authors
- Koumoutsakos, P., Pivkin, I., & Milde, F.
- Affiliations
- ETH Zurich (CH)
- Università della Svizzera italiana (CH)
- Venue
- Annual Review of Fluid Mechanics
- Publisher
- Annual Reviews
- Published
- 2013-01-03
- Volume
- 45
- Issue
- 1
- Pages
- 325-355
- ISSN
- 0066-4189 (ISSN-L)
- 1545-4479
- OpenAlex
- W2096404892
- Cited by
- 129
- References
- 218
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 10 · 2018: 20 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Fluid Mechanics (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor vasculature, tumor microenvironment, metastasis, nanoparticle drug delivery, tumor growth, cancer therapy
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