The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Nutraceutical Bioavailability Classification Scheme: Classifying Nutraceuticals According to Factors Limiting their Oral Bioavailability
Open accessAbstract
The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors important for understanding nutraceutical bioavailability in foods. The article also highlights potential strategies for increasing the oral bioavailability of nutraceuticals based on their NuBACS designation (B*A*T*).
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Cites
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Vitamin A metabolism: An update
D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562
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Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary β-Carotene and Cholesterol
van Bennekum, A., Werder, M., Thuahnai, S. T., Han, C.-H., Duong, P., Williams, D. L., Wettstein, P., Schulthess, G., Phillips, M. C., & Hauser, H. (2005) · Biochemistry · doi:10.1021/bi0484320 · Cited by 290
A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila
Kiefer, C., Sumser, E., Wernet, M. F., & von Lintig, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162182899 · Cited by 255
Cited by
Mangiferin and Cancer: Mechanisms of Action
Gold-Smith, F., Fernandez, A., & Bishop, K. (2016) · Nutrients · doi:10.3390/nu8070396 · Cited by 158
Machado, A. R., Silva, P. M. P., Vicente, A. A., Souza-Soares, L. A., Pinheiro, A. C., & Cerqueira, M. A. (2022) · Polymers · doi:10.3390/polym14214759 · Cited by 57
Metadata
- Authors
- McClements, D. J., Li, F., & Xiao, H.
- Venue
- Annual Review of Food Science and Technology
- Publisher
- Annual Reviews
- Published
- 2015-04-10
- Volume
- 6
- Issue
- 1
- Pages
- 299-327
- ISSN
- 1941-1421 (ISSN-L)
- 1941-1413
- OpenAlex
- W2152871789
- Cited by
- 315
- References
- 7
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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