Museum Genomics
Open accessAbstract
Natural history collections are invaluable repositories of biological information that provide an unrivaled record of Earth's biodiversity. Museum genomics—genomics research using traditional museum and cryogenic collections and the infrastructure supporting these investigations—has particularly enhanced research in ecology and evolutionary biology, the study of extinct organisms, and the impact of anthropogenic activity on biodiversity. However, leveraging genomics in biological collections has exposed challenges, such as digitizing, integrating, and sharing collections data; updating practices to ensure broadly optimal data extraction from existing and new collections; and modernizing collections practices, infrastructure, and policies to ensure fair, sustainable, and genomically manifold uses of museum collections by increasingly diverse stakeholders. Museum genomics collections are poised to address these challenges and, with increasingly sensitive genomics approaches, will catalyze a future era of reproducibility, innovation, and insight made possible through integrating museum and genome sciences.
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Newfound efficacy with the sequencing of genomes from preserved museum specimens promises to soon fill many populational gaps.
“Sampling difficulties are often exacerbated by the costs of fieldwork, specimen curation, and genome sequencing, but newfound efficacy with the sequencing of genomes from preserved museum specimens promises to soon fill many populational gaps (e.g., Card et al. 2021; Raxworthy and Smith 2021; Benham and Bowie 2023).”
From How many mammal species are there now? Updates and trends in taxonomic, nomenclatural, and geographic knowledge (2025) · cites this paper as Card et al. 2021
Cites
Crutzen, P. J. (2002) · Nature · doi:10.1038/415023a · Cited by 4,788 · see citing works
Has the Earth’s sixth mass extinction already arrived?
Barnosky, A. D., Matzke, N., Tomiya, S., Wogan, G. O. U., Swartz, B., Quental, T. B., Marshall, C., McGuire, J. L., Lindsey, E. L., Maguire, K. C., et al. (2011) · Nature · doi:10.1038/nature09678 · Cited by 4,400 · cited 1× · see citing works
“This unfolding sixth mass extinction (7), dubbed the Anthropocene (38), has resulted in an unplanned experiment providing insight into the resilience of species and ecosystems to rapid change and the capacity for rapid and sustainable evolution (101).”
BackgroundData integration enables global biodiversity synthesis
Heberling, J. M., Miller, J. T., Noesgaard, D., Weingart, S. B., & Schigel, D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018093118 · Cited by 380 · see citing works
Origins and genetic legacy of prehistoric dogs
Bergström, A., Frantz, L., Schmidt, R., Ersmark, E., Lebrasseur, O., Girdland-Flink, L., Lin, A. T., Storå, J., Sjögren, K.-G., Anthony, D., et al. (2020) · Science · doi:10.1126/science.aba9572 · Cited by 297 · see citing works
Climate-induced range contraction drives genetic erosion in an alpine mammal
Rubidge, E. M., Patton, J. L., Lim, M., Burton, A. C., Brashares, J. S., & Moritz, C. (2012) · Nature Climate Change · doi:10.1038/nclimate1415 · Cited by 169 · see citing works
Self-citationCollaborative Archaeologies and Descendant Communities
Colwell, C. (2016) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102215-095937 · Cited by 167 · cited 1× · see citing works
“Overall, the museum community generally acknowledges the continued need for such protocols after decades of sometimes less-than-satisfactory inclusion or acknowledgment of researchers, infrastructure, and investment (33).”
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Single-cell brain organoid screening identifies developmental defects in autism
Li, C., Fleck, J. S., Martins-Costa, C., Burkard, T. R., Themann, J., Stuempflen, M., Peer, A. M., Vertesy, Á., Littleboy, J. B., Esk, C., et al. (2023) · Nature · doi:10.1038/s41586-023-06473-y · Cited by 283 · see citing works
Burgin, C. J., Zijlstra, J. S., Becker, M. A., Handika, H., Alston, J. M., Widness, J., Liphardt, S., Huckaby, D. G., & Upham, N. S. (2025) · Journal of Mammalogy · doi:10.1093/jmammal/gyaf047 · Cited by 28 · see citing works
- Authors
- Card, D. C., Shapiro, B., Giribet, G., Moritz, C., & Edwards, S. V.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Australian National University (AU)
- Corresponding author
- Edwards, Scott V.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2021-11-23
- Volume
- 55
- Issue
- 1
- Pages
- 633-659
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W4200243080
- Cited by
- 151
- References
- 6
- Citations by year
- 2026: 24 · 2025: 40 · 2024: 35 · 2023: 28 · 2022: 21 · 2021: 3
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Annual Review of Genetics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- National Science Foundation (1812310, 1946857, 1831560)
- Topics
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Physical Sciences › Environmental Science › Ecology › Environmental DNA in Biodiversity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- natural history collections, collection digitization, data sharing, collection management, biodiversity, extinct species, human impact on biodiversity, reproducibility
- MeSH terms
- Biological Evolution, Museums, Reproducibility of Results, Genomics, Biodiversity
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