The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Integrative and Conjugative Elements (ICEs): What They Do and How They Work
Open accessAbstract
Horizontal gene transfer plays a major role in microbial evolution, allowing microbes to acquire new genes and phenotypes. Integrative and conjugative elements (ICEs, a.k.a. conjugative transposons) are modular mobile genetic elements integrated into a host genome and are passively propagated during chromosomal replication and cell division. Induction of ICE gene expression leads to excision, production of the conserved conjugation machinery (a type IV secretion system), and the potential to transfer DNA to appropriate recipients. ICEs typically contain cargo genes that are not usually related to the ICE life cycle and that confer phenotypes to host cells. We summarize the life cycle and discovery of ICEs, some of the regulatory mechanisms, and how the types of cargo have influenced our view of ICEs. We discuss how ICEs can acquire new cargo genes and describe challenges to the field and various perspectives on ICE biology.
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Metadata
- Authors
- Johnson, C. M., & Grossman, A. D.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2015-11-23
- Volume
- 49
- Issue
- 1
- Pages
- 577-601
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W1832517154
- Cited by
- 605
- References
- 133
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Johnson, C. M., & Grossman, A. D. (2015). Integrative and Conjugative Elements (ICEs): What They Do and How They Work. Annual Review of Genetics. https://doi.org/10.1146/annurev-genet-112414-055018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
