Cited by 501Gut microbiota and healthGastrointestinal motility and disordersImmune Response and Inflammation

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Microbial Translocation Across the GI Tract

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Brenchley, Jason M., Douek, Daniel C.·2012·Annual Review of Immunology

DOI 10.1146/annurev-immunol-020711-075001PMC PMC3513328

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Abstract

The lumen of the gastrointestinal (GI) tract is home to an enormous quantity of different bacterial species, our microbiota, that thrive in an often symbiotic relationship with the host. Given that the healthy host must regulate contact between the microbiota and its immune system to avoid overwhelming systemic immune activation, humans have evolved several mechanisms to attenuate systemic microbial translocation (MT) and its consequences. However, several diseases are associated with the failure of one or more of these mechanisms, with consequent immune activation and deleterious effects on health. Here, we discuss the mechanisms underlying MT, diseases associated with MT, and therapeutic interventions that aim to decrease it.

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Additional file 5 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682871
Additional file 1 of Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy
Isnard, S., Royston, L., Scott, S. C., Mabanga, T., Lin, J., Fombuena, B., Bu, S., Berini, C. A., Goldberg, M. S., Finkelman, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26590221
Additional file 21 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682919
Additional file 11 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682889
Additional file 16 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682904
Additional file 10 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682886
Additional file 12 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682892
Additional file 4 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682868
Additional file 13 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682895
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Additional file 18 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682910
Additional file 19 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682913
Additional file 6 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682874
Additional file 17 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682907
Additional file 9 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682883
Additional file 15 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682901
Additional file 2 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682862
Additional file 8 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682880
Additional file 3 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682865
Additional file 7 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682877
Additional file 14 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682898
Additional file 1 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682859
Additional file 20 of Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682916
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Influential

Authors: Brenchley, J. M., & Douek, D. C.
Affiliations: National Institutes of Health (US)
ORCID: Brenchley, Jason M.
Douek, Daniel C.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2012-04-23
Volume: 30
Issue: 1
Pages: 149-173
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-020711-075001
PMC: PMC3513328
OpenAlex: W2146488133
Cited by: 496
References: 222
Citations by year: 2026: 22 · 2025: 32 · 2024: 42 · 2023: 30 · 2022: 44 · 2021: 33 · 2020: 42 · 2019: 59 · 2018: 24 · 2017: 40 · 2016: 34 · 2015: 20 · 2014: 27 · 2013: 32 · 2012: 15
FWCI: 2.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (Z01AI001029, ZIAAI005034)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: microbial translocation, gut microbiota, gastrointestinal tract, host-microbe interactions, immune activation, systemic inflammation, therapeutic interventions
MeSH terms: Animals, Anti-Infective Agents, Digestive System Diseases, Humans, Immunologic Factors, Probiotics, Gastrointestinal Tract, Host-Pathogen Interactions, Metagenome

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Microbial Translocation Across the GI Tract

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