Deciphering mechanisms and implications of bacterial translocation in human health and disease
Abstract
Significant increases in potential microbial translocation, especially along the oral-gut axis, have been identified in many immune-related and inflammatory diseases, such as inflammatory bowel disease, colorectal cancer, rheumatoid arthritis, and liver cirrhosis, for which we currently have no cure or long-term treatment options. Recent advances in computational and experimental omics approaches now enable strain tracking, functional profiling, and strain isolation in unprecedented detail, which has the potential to elucidate the causes and consequences of microbial translocation. In this review, we discuss current evidence for the detection of bacterial translocation, examine different translocation axes with a primary focus on the oral-gut axis, and outline currently known translocation mechanisms and how they adversely affect the host in disease. Finally, we conclude with an overview of state-of-the-art computational and experimental tools for strain tracking and highlight the required next steps to elucidate the role of bacterial translocation in human health.
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Confronting risks of mirror life
Adamala, K. P., Agashe, D., Belkaid, Y., Bittencourt, D. M. D. C., Cai, Y., Chang, M. W., Chen, I. A., Church, G. M., Cooper, V. S., Davis, M. M., et al. (2024) · Science · doi:10.1126/science.ads9158 · Cited by 91 · see citing works
- Authors
- Jin, S., Wetzel, D., & Schirmer, M.
- Affiliations
- Technical University of Munich (DE)
- Corresponding author
- Schirmer, Melanie
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 67
- Pages
- 102147
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W4224296268
- Cited by
- 39
- References
- 167
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 9 · 2023: 8 · 2022: 3
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- bacterial translocation, oral-gut axis, inflammatory bowel disease, colorectal cancer, rheumatoid arthritis, liver cirrhosis, strain tracking, gut microbiota, host-microbe interactions, translocation mechanism
- MeSH terms
- Humans, Liver Cirrhosis, Inflammatory Bowel Diseases, Bacterial Translocation
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