Cited by 3,452T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Differentiation of Effector CD4 T Cell Populations

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Zhu, Jinfang, Yamane, Hidehiro, Paul, William E.·2010·Annual Review of Immunology

DOI 10.1146/annurev-immunol-030409-101212PMC PMC3502616

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Abstract

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, Th17, and iTreg, as defined by their pattern of cytokine production and function. In this review, we summarize the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.

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Authors: Zhu, J., Yamane, H., & Paul, W. E.
Affiliations: National Institutes of Health (US)
ORCID: Zhu, Jinfang
Yamane, Hidehiro
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2010-03-01
Volume: 28
Issue: 1
Pages: 445-489
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-030409-101212
PMC: PMC3502616
OpenAlex: W2152014155
Cited by: 3,452
References: 313
Citations by year: 2026: 133 · 2025: 177 · 2024: 208 · 2023: 205 · 2022: 247 · 2021: 283 · 2020: 223 · 2019: 224 · 2018: 259 · 2017: 234 · 2016: 203 · 2015: 209 · 2014: 237 · 2013: 210 · 2012: 173
FWCI: 15.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 AI999999)
National Institute of Allergy and Infectious Diseases (Y99 AI999999)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: CD4+ T cell differentiation, Th1 cells, Th2 cells, Th17 cells, induced regulatory T cells, T cell activation, cytokine signaling, transcription factors, epigenetic regulation, autoimmunity, asthma, allergic reactions, antitumor immunity
MeSH terms: Animals, Cell Differentiation, Humans, Transcription Factors, Signal Transduction, CD4-Positive T-Lymphocytes, Cytokines, Cell Lineage

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Differentiation of Effector CD4 T Cell Populations

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