The DOI matches its Crossref record; 384 of the 384 references it cites were found in a registry or an index.
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
Open accessAbstract
The human intestine is colonized by an estimated 100 trillion bacteria. Some of these bacteria are essential for normal physiology, whereas others have been implicated in the pathogenesis of multiple inflammatory diseases including IBD and asthma. This review examines the influence of signals from intestinal bacteria on the homeostasis of the mammalian immune system in the context of health and disease. We review the bacterial composition of the mammalian intestine, known bacterial-derived immunoregulatory molecules, and the mammalian innate immune receptors that recognize them. We discuss the influence of bacterial-derived signals on immune cell function and the mechanisms by which these signals modulate the development and progression of inflammatory disease. We conclude with an examination of successes and future challenges in using bacterial communities or their products in the prevention or treatment of human disease.
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“On the one hand, they can supply essential nutrients, synthesize vitamin K, aid in the digestion of cellulose, and promote angiogenesis and enteric nerve function [7–9].”
Background
Metadata
- Authors
- Hill, D. A., & Artis, D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 623-667
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2109843135
- Cited by
- 586
- References
- 384
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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