Cited by 1,426Gut microbiota and healthT-cell and B-cell ImmunologyInflammatory Bowel Disease

The role of gut microbiota in immune homeostasis and autoimmunity

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Wu, Hsin-Jung, Wu, Eric·2012·Gut Microbes

Abstract

Keeping a delicate balance in the immune system by eliminating invading pathogens, while still maintaining self-tolerance to avoid autoimmunity, is critical for the body's health. The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Here we review the advances in our understanding of how the gut microbiota regulates innate and adaptive immune homeostasis, which in turn can affect the development of not only intestinal but also systemic autoimmune diseases. Exploring the interaction of gut microbes and the host immune system will not only allow us to understand the pathogenesis of autoimmune diseases but will also provide us new foundations for the design of novel immuno- or microbe-based therapies.

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Authors
Wu, H.-J., & Wu, E.
Affiliations
University of Arizona (US)
Corresponding author
Wu, Hsin-Jung
Venue
Gut Microbes
Published
2012-01
Volume
3
Issue
1
Pages
4-14
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
OpenAlex
W2048502267
Cited by
1,426
References
118
Citations by year
2026: 84 · 2025: 177 · 2024: 244 · 2023: 189 · 2022: 191 · 2021: 171 · 2020: 83 · 2019: 77 · 2018: 78 · 2017: 55 · 2016: 39 · 2015: 21 · 2014: 8 · 2013: 8 · 2012: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
gut microbiota, immune homeostasis, autoimmunity, autoimmune disease, innate immunity, adaptive immunity, self-tolerance, immune dysregulation, systemic autoimmune diseases, microbiota-based therapy
MeSH terms
Animals, Homeostasis, Humans, Immune System, Autoimmunity, Gastrointestinal Tract, Metagenome

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