The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Inflammasome-Independent Regulation of IL-1-Family Cytokines
Open accessAbstract
Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities. With the exception of the IL-1 receptor antagonist, all IL-1 family cytokines lack a signal peptide and require proteolytic processing into an active molecule. One such unique protease is caspase-1, which is activated by protein platforms called the inflammasomes. However, increasing evidence suggests that inflammasomes and caspase-1 are not the only mechanism for processing IL-1 cytokines. IL-1 cytokines are often released as precursors and require extracellular processing for activity. Here we review the inflammasome-independent enzymatic processes that are able to activate IL-1 cytokines, paying special attention to neutrophil-derived serine proteases, which subsequently induce inflammation and modulate host defense. The inflammasome-independent processing of IL-1 cytokines has important consequences for understanding inflammatory diseases, and it impacts the design of IL-1-based modulatory therapies.
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“the literature suggests that IL-1β can also be processed to a mature cytokine through inflammasome-independent pathways.54”
From TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling (2024) · cites this paper as [54]
In the citing paper
“several inflammasome-independent or noncanonical pathways have been characterized, which also result in caspase activation and maturation of IL-1β (Netea et al, 2015).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Netea et al, 2015
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“inflammasome-dependent activation of IL-1β is cell type specific (Netea et al, 2015).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Netea et al, 2015
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Metadata
- Authors
- Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B.
- Affiliations
- Radboud University Medical Center (NL)
- Department of Internal Medicine,
- University of Colorado Anschutz (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2015-03-21
- Volume
- 33
- Issue
- 1
- Pages
- 49-77
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2156301166
- Cited by
- 326
- References
- 228
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 26 · 2023: 15 · 2022: 24 · 2021: 27 · 2020: 30 · 2019: 33 · 2018: 46 · 2017: 46 · 2016: 41 · 2015: 24
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institutes of Health (CA-04-6934, 15614, AI‐15614)
- National Cancer Institute (CA 046934, P30CA046934)
- National Institute of Allergy and Infectious Diseases (AI‑15614)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR‑45584, R01AR045584)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- caspase-1, neutrophil serine proteases, inflammatory cytokines, cytokine activation, host defense, inflammatory diseases
- MeSH terms
- Animals, Disease Susceptibility, Humans, Inflammation, Interleukin-1, Cytokines, Inflammation Mediators, Inflammasomes
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