Inflammasome-Independent Regulation of IL-1-Family Cytokines

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Biologic basis for interleukin-1 in disease.

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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Cloning of a new cytokine that induces IFN-γ production by T cells

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Mechanisms and Functions of Inflammasomes

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Non-canonical inflammasome activation targets caspase-11

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The Inflammasomes: Guardians of the Body

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

Dinarello, C. A. (2011) · Blood · doi:10.1182/blood-2010-07-273417 · Cited by 2,248

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

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The interleukin-1 family: back to the future

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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Molecular Cloning of the Interleukin-1β Converting Enzyme

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

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TH17 cells in development: an updated view of their molecular identity and genetic programming

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The P2X7 Receptor: A Key Player in IL-1 Processing and Release

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

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An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Interleukin-18 and IL-18 Binding Protein

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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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IL-37 is a fundamental inhibitor of innate immunity

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Structure and mechanism of interleukin-lβ converting enzyme

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Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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A pilot study of IL-1 inhibition by anakinra in acute gout

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

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Inflammasome activation and IL-1β and IL-18 processing during infection

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NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

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The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

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Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

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NALP1 in Vitiligo-Associated Multiple Autoimmune Disease

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

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From evolutionary genetics to human immunology: how selection shapes host defence genes

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An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

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Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

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IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

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Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

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Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

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Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

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Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis

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The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo

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IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

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IL-1β Processing in Host Defense: Beyond the Inflammasomes

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Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

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Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

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Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors

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Identification of a membrane-associated interleukin 1 in macrophages.

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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

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Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

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Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

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Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis

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A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release

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Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

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IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

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Interleukin (IL)-1F6, IL-1F8, and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-κB and MAPKs

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The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

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The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene Transcription

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Four New Members Expand the Interleukin-1 Superfamily

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Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

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Engagement of fatty acids with toll‐like receptor 2 drives interleukin‐1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal–induced gouty arthritis

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Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo

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Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

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Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

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Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

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Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2

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Interleukin‐1 Signaling Is Essential for Host Defense during Murine Pulmonary Tuberculosis

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Caspase-1-Mediated Activation of Interleukin-1β (IL-1β) and IL-18 Contributes to Innate Immune Defenses againstSalmonella entericaSerovar Typhimurium Infection

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Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis

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Interleukin-18 and the Pathogenesis of Inflammatory Diseases

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Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

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The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines

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Differences in signaling pathways by IL-1β and IL-18

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Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

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Interleukin-18, a proinflammatory cytokine.

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An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

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The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis

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Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue

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Cloning and Characterization of IL-1HY2, a Novel Interleukin-1 Family Member

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Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

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Neutralization of IL-18 Reduces Neutrophil Tissue Accumulation and Protects Mice Against Lethal Escherichia coli and Salmonella typhimurium Endotoxemia

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Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

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The role of interleukin‐1 and the inflammasome in gout: Implications for therapy

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Pathophysiological roles of interleukin-18 in inflammatory liver diseases

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Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

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Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection

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Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

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Altered Immune Responses and Susceptibility to Leishmania major and Staphylococcus aureus Infection in IL-18-Deficient Mice

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Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes

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Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis

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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

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Beneficial response to interleukin 1 receptor antagonist in traps

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IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis

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Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

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Regulation and Function of the IL-1 Family Cytokine IL-1F9 in Human Bronchial Epithelial Cells

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The inflammatory response in interleukin-1β-deficient mice: comparison with other cytokine-related knock-out mice.

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Interleukin‐1‐induced neurotoxicity is mediated by glia and requires caspase activation and free radical release

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Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1β and Interleukin-18

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Psychosocial effect of common skin diseases.

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The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

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The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes

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Entamoeba histolytica cysteine proteinases with interleukin‐1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis

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Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity

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Identification of a Novel Human Cytokine Gene in the Interleukin Gene Cluster on Chromosome 2q12-14

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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

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