The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target
Abstract
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a “don't-eat-me” signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation.
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“Of note, in some preclinical and clinical instances, the activity of surface-exposed CALR is antagonized by CD47, which operates as a “don’t eat me” signal as it inhibits phagocytosis by DCs and macrophages upon interaction with signal regulatory protein alpha (SIRPA) [885, 886].”
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Metadata
- Authors
- Barclay, A. N., & van den Berg, T. K.
- Affiliations
- University of Oxford (GB)
- Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands;
- ORCID
- Barclay, A. Neil
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 25-50
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2139418176
- Cited by
- 841
- References
- 155
- Citations by year
- 2026: 63 · 2025: 107 · 2024: 108 · 2023: 84 · 2022: 77 · 2021: 89 · 2020: 89 · 2019: 51 · 2018: 44 · 2017: 60 · 2016: 32 · 2015: 26 · 2014: 11
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- CD47, SIRPα, don't eat me signal, phagocytosis, immune evasion, autoimmunity, host defense, cancer immunotherapy, inflammation, xenotransplantation, graft survival, receptor evolution
- MeSH terms
- Animals, Antigens, Differentiation, Autoimmune Diseases, Dendritic Cells, Multigene Family, Hematologic Diseases, Humans, Neoplasms, Phagocytosis, Protein Binding, Receptors, Immunologic, T-Lymphocytes, Signal Transduction, CD47 Antigen, Immunological Synapses, Molecular Targeted Therapy
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