Cited by 847Phagocytosis and Immune RegulationCell death mechanisms and regulationInflammasome and immune disorders

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The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

Barclay, A. Neil, van den Berg, Timo K.·2014·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032713-120142

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Abstract

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a “don't-eat-me” signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation.

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Evolution of the Ly49 and Nkrp1 recognition systems
Carlyle, J. R., Mesci, A., Fine, J. H., Chen, P., Bélanger, S., Tai, L., & Makrigiannis, A. P. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.05.004 · Cited by 103
Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines
Kim, M. J., Lee, J.-C., Lee, J., Kim, S., Lee, S. G., Park, S., Sung, M. W., & Heo, D. S. (2008) · Tumor Biology · doi:10.1159/000132568 · Cited by 101
Subsets of migrating intestinal dendritic cells
Milling, S. W. F., Yrlid, U., Cerovic, V., & MacPherson, G. G. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00866.x · Cited by 101
Endothelial CD47 interaction with SIRPγ is required for human T-cell transendothelial migration under shear flow conditions in vitro
Stefanidakis, M., Newton, G. A., Lee, W. Y., Parkos, C. A., & Luscinskas, F. W. (2008) · Blood · doi:10.1182/blood-2008-01-134429 · Cited by 99
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47 null cells
Wang, H., Madariaga, M. L. L., Wang, S., van Rooijen, N., Oldenborg, P., & Yang, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702881104 · Cited by 94
On the origins of adaptive immunity: innate immune receptors join the tale
VandenBerg, T., Yoder, J. A., & Litman, G. W. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.11.006 · Cited by 93
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Cell polarisation and the immunological synapse
Angus, K. L., & Griffiths, G. M. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.013 · Cited by 93
Expression of the self‐marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs
Van, V. Q., Lesage, S., Bouguermouh, S., Gautier, P., Rubio, M., Lévesque, M., Nguyen, S., Galibert, L., & Sarfati, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601415 · Cited by 92
CD200R signaling in tumor tolerance and inflammation: A tricky balance
Rygiel, T. P., & Meyaard, L. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.002 · Cited by 88
Role of the CD47–SHPS‐1 system in regulation of cell migration
Motegi, S., Okazawa, H., Ohnishi, H., Sato, R., Kaneko, Y., Kobayashi, H., Tomizawa, K., Ito, T., Honma, N., Bühring, H., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg278 · Cited by 87
How the immune system talks to itself: the varied role of synapses
Xie, J., Tato, C. M., & Davis, M. M. (2012) · Immunological Reviews · doi:10.1111/imr.12017 · Cited by 85
Innate Immune Activation during Salmonella Infection Initiates Extramedullary Erythropoiesis and Splenomegaly
Jackson, A., Nanton, M. R., O’Donnell, H., Akue, A. D., & McSorley, S. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001198 · Cited by 85
Selective control of SIRP-α–positive airway dendritic cell trafficking through CD47 is critical for the development of TH2-mediated allergic inflammation
Raymond, M., Rubio, M., Fortin, G., Shalaby, K. H., Hammad, H., Lambrecht, B. N., & Sarfati, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.021 · Cited by 84
A role for CD47 in the development of experimental colitis mediated by SIRPα+CD103− dendritic cells
Fortin, G., Raymond, M., Van, V. Q., Rubio, M., Gautier, P., Sarfati, M., & Franchimont, D. P. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082805 · Cited by 80
Neurotrophin expression by spinal motoneurons in adult and developing rats
Buck, C. R., Seburn, K. L., & Cope, T. C. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000117)416:3 · Cited by 80
The Structure of the Macrophage Signal Regulatory Protein α (SIRPα) Inhibitory Receptor Reveals a Binding Face Reminiscent of That Used by T Cell Receptors
Hatherley, D., Harlos, K., Dunlop, D. C., Stuart, D. I., & Barclay, A. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611511200 · Cited by 78
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Innate immune ‘self’ recognition: a role for CD47–SIRPα interactions in hematopoietic stem cell transplantation
van den Berg, T. K., & van der Schoot, C. E. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.02.004 · Cited by 78
Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo
Cameron, C., Barrett, J. W., Mann, M. J., Lucas, A., & McFadden, G. (2005) · Virology · doi:10.1016/j.virol.2005.03.037 · Cited by 74
CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia
Su, X., Johansen, M. L., Looney, M. R., Brown, E. J., & Matthay, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6947 · Cited by 72
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47
Soto‐Pantoja, D. R., Stein, E. V., Rogers, N. M., Sharifi‐Sanjani, M., Isenberg, J. S., & Roberts, D. D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.733699 · Cited by 67
Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis
Kuriyama, T., Takenaka, K., Kohno, K., Yamauchi, T., Daitoku, S., Yoshimoto, G., Kikushige, Y., Kishimoto, J., Abe, Y., Harada, N., et al. (2012) · Blood · doi:10.1182/blood-2012-02-408864 · Cited by 67
Phylogenetic Divergence of CD47 Interactions with Human Signal Regulatory Protein α Reveals Locus of Species Specificity
Subramanian, S., Boder, E. T., & Discher, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603923200 · Cited by 66
The Counterbalance Theory for Evolution and Function of Paired Receptors
Barclay, A. N., & Hatherley, D. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.004 · Cited by 65
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Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution
Hatherley, D., Lea, S. M., Johnson, S., & Barclay, A. N. (2013) · Structure · doi:10.1016/j.str.2013.03.008 · Cited by 65
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Macrophage Activation by Immunostimulatory DNA
Stacey, K. J., Sester, D. P., Sweet, M. J., & Hume, D. A. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59672-8_3 · Cited by 64
Dual Regulation of SIRPα Phosphorylation by Integrins and CD47
Johansen, M. L., & Brown, E. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701565200 · Cited by 59
Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein α
Liu, Y., O’Connor, M. B., Mandell, K. J., Zen, K., Ullrich, A., Bühring, H., & Parkos, C. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2578 · Cited by 58
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement
Alenghat, F. J., Baca, Q. J., Rubin, N. T., Pao, L. I., Matozaki, T., Lowell, C. A., Golan, D. E., Neel, B. G., & Swanson, K. D. (2012) · Journal of Cell Science · doi:10.1242/jcs.111260 · Cited by 58
CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1β and TNF
Baba, N., Van, V. Q., Wakahara, K., Rubio, M., Fortin, G., Panzini, B., Soucy, G., Wassef, R., Richard, C. S., Tamaz, R., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122037 · Cited by 57
Molecular Recognition of Paired Receptors in the Immune System
Kuroki, K., Furukawa, A., & Maenaka, K. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00429 · Cited by 56
Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia
Uno, S., Kinoshita, Y., Azuma, Y., Tsunenari, T., Yoshimura, Y., Iida, S., Kikuchi, Y., Yamada‐Okabe, H., & Fukushima, N. (2007) · Oncology Reports · doi:10.3892/or.17.5.1189 · Cited by 56
Expression of CD200 on AML blasts directly suppresses memory T-cell function
Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S., Darley, R. L., & Tonks, A. (2012) · Leukemia · doi:10.1038/leu.2012.77 · Cited by 55
Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules
Umemori, H., & Sanes, J. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805729200 · Cited by 54
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice
Tomizawa, T., Kaneko, Y., Kaneko, Y., Saito, Y., Ohnishi, H., Okajo, J., Okuzawa, C., Ishikawa-Sekigami, T., Murata, Y., Okazawa, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.869 · Cited by 52
Signal regulatory protein α negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction
Dong, L., Kong, X., Yan, H., Yu, L., Chen, L., Yang, W., Liu, Q., Huang, D., Wu, M., & Wang, H. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.03.012 · Cited by 50
An essential role for the association of CD47 to SHPS-1 in skeletal remodeling
Maile, L. A., DeMambro, V., Wai, C., Aday, A. W., Capps, B. E., Beamer, W. G., Rosen, C. J., & Clemmons, D. R. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.441 · Cited by 45
The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L
Viertlboeck, B. C., Schmitt, R., & Göbel, T. (2006) · Immunogenetics · doi:10.1007/s00251-006-0091-8 · Cited by 45
Structure of Signal-regulatory Protein α
Hatherley, D., Graham, S. C., Harlos, K., Stuart, D. I., & Barclay, A. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017566 · Cited by 44
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Novel CD47-dependent intercellular adhesion modulates cell migration
Rebres, R. A., Kajihara, K. K., & Brown, E. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20379 · Cited by 44
Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate 1 Regulates the Migration of Langerhans Cells from the Epidermis to Draining Lymph Nodes
Fukunaga, A., Nagai, H., Noguchi, T., Okazawa, H., Matozaki, T., Yu, X., Lagenaur, C. F., Honma, N., Ichihashi, M., Kasuga, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4091 · Cited by 44
How do pathogens drive the evolution of paired receptors?
Akkaya, M., & Barclay, A. N. (2012) · European Journal of Immunology · doi:10.1002/eji.201242896 · Cited by 42
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CD47 Is Required for Suppression of Allograft Rejection by Donor-Specific Transfusion
Wang, H., Wu, X., Wang, Y., Oldenborg, P., & Yang, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901550 · Cited by 39
Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal‐regulatory protein‐α,β on monocytes from patients with warm autoimmune hemolytic anemia
Barros, M. M. O., Yamamoto, M., Figueiredo, M. S., Cançado, R. D., Kimura, E. Y. S., Langhi, D. M., CHIATTONE, C. S., & Bordin, J. O. (2008) · Transfusion · doi:10.1111/j.1537-2995.2008.01936.x · Cited by 39
Signal Regulatory Protein α Regulates the Homeostasis of T Lymphocytes in the Spleen
Sato‐Hashimoto, M., Saito, Y., Ohnishi, H., Iwamura, H., Kanazawa, Y., Kaneko, T., Kusakari, S., Kotani, T., Mori, M., Murata, Y., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100528 · Cited by 37
SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone.
Carter‐Su, C., Rui, L., & Stofega, M. R. (2000) · PubMed · Cited by 36
Semimature Stage: A Checkpoint in a Dendritic Cell Maturation Program That Allows for Functional Reversion after Signal-Regulatory Protein-α Ligation and Maturation Signals
Braun, D., Galibert, L., Nakajima, T., Saito, H., Van, V. Q., Rubio, M., & Sarfati, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8550 · Cited by 36
On the mechanism of CD47 targeting in cancer
Zhao, X. W., Matlung, H. L., Kuijpers, T. W., & van den Berg, T. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209265109 · Cited by 35
A new disulfide‐linked dimer of a single‐chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor‐1α pathway
Sagawa, M., Shimizu, T., Fukushima, N., Kinoshita, Y., Ohizumi, I., Uno, S., Kikuchi, Y., Ikeda, Y., Yamada‐Okabe, H., & Kizaki, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01925.x · Cited by 34
A Nomenclature for Signal Regulatory Protein Family Members
van den Berg, T. K., van Beek, E. M., Bühring, H.-J., Colonna, M., Hamaguchi, M., Howard, C. J., Kasuga, M., Liu, Y., Matozaki, T., Neel, B. G., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.7788 · Cited by 33
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Is targeting of CD47-SIRPα enough for treating hematopoietic malignancy?
Zhao, X. W., Kuijpers, T. W., & van den Berg, T. K. (2012) · Blood · doi:10.1182/blood-2011-11-391367 · Cited by 32
SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox
van Beek, E. M., Zárate, J. Á., van Bruggen, R., Schornagel, K., Tool, A. T. J., Matozaki, T., Kraal, G., Roos, D., & van den Berg, T. K. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.027 · Cited by 31
Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47
Wang, C., Wang, H., Ide, K., Wang, Y., van Rooijen, N., Ohdan, H., & Yang, Y. (2011) · Cell Transplantation · doi:10.3727/096368911x566253 · Cited by 31
Lack of CD47 on Donor Hepatocytes Promotes Innate Immune Cell Activation and Graft Loss: A Potential Barrier to Hepatocyte Xenotransplantation
Navarro–Álvarez, N., & Yang, Y. (2013) · Cell Transplantation · doi:10.3727/096368913x663604 · Cited by 31
Inhibition of Macrophage Activation by the Myxoma Virus M141 Protein (vCD200)
Zhang, L., Stanford, M. M., Liu, J., Barrett, C., Jiang, L., Barclay, A. N., & McFadden, G. (2009) · Journal of Virology · doi:10.1128/jvi.01078-09 · Cited by 31
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Leishmania donovani‐induced expression of signal regulatory protein α on Kupffer cells enhances hepatic invariant NKT‐cell activation
Beattie, L., Svensson, M., Bune, A. J., Brown, N., Maroof, A., Zubairi, S., Smith, K. R., & Kaye, P. M. (2009) · European Journal of Immunology · doi:10.1002/eji.200939863 · Cited by 30
Surfactant Protein D (Sp-D) Binds to Membrane-proximal Domain (D3) of Signal Regulatory Protein α (SIRPα), a Site Distant from Binding Domain of CD47, while Also Binding to Analogous Region on Signal Regulatory Protein β (SIRPβ)
Fournier, B., Andargachew, R., Robin, A. Z., Laur, O., Voelker, D. R., Lee, W. Y., Weber, D. A., & Parkos, C. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324533 · Cited by 28
The CD47 pathway is deregulated in human immune thrombocytopenia
Catani, L., Sollazzo, D., Ricci, F., Polverelli, N., Palandri, F., Baccarani, M., Vianelli, N., & Lemoli, R. M. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2010.12.011 · Cited by 27
Structural Insight into the Specific Interaction between Murine SHPS-1/SIRPα and Its Ligand CD47
Nakaishi, A., Hirose, M., Yoshimura, M., Oneyama, C., Saito, K., Kuki, N., Matsuda, M., Honma, N., Ohnishi, H., Matozaki, T., et al. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.10.085 · Cited by 25
Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies
Soto‐Pantoja, D. R., Miller, T. W., Frazier, W. A., & Roberts, D. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205441109 · Cited by 25
Resistance to collagen-induced arthritis in SHPS-1 mutant mice
Okuzawa, C., Kaneko, Y., Murata, Y., Miyake, A., Saito, Y., Okajo, J., Tomizawa, T., Kaneko, Y., Okazawa, H., Ohnishi, H., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.124 · Cited by 25
CD47high Expression on CD4 Effectors Identifies Functional Long-Lived Memory T Cell Progenitors
Van, V. Q., Raymond, M., Baba, N., Rubio, M., Wakahara, K., Susín, S. A., & Sarfati, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102702 · Cited by 25
Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of α-Galactosylceramide-Induced Antimetastatic Activity and Th1 and Th2 Responses of NKT Cells
Okajo, J., Kaneko, Y., Murata, Y., Tomizawa, T., Okuzawa, C., Saito, Y., Kaneko, Y., Ishikawa-Sekigami, T., Okazawa, H., Ohnishi, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6164 · Cited by 24
Integrin-associated protein (IAP)-deficient mice are less susceptible to developing -induced arthritis
Verdrengh, M., Lindberg, F. P., Rydèn, C., & Tarkowski, A. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80076-8 · Cited by 24
Paired Receptor Systems of the Innate Immune System
Yamada, E., & McVicar, D. W. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.ima01xs81 · Cited by 22
Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice
Waern, J., Yuan, Q., Rüdrich, U., Becker, P. D., Schulze, K., Strick‐Marchand, H., Huntington, N. D., Zacher, B. J., Wursthorn, K., Santo, J. P. D., et al. (2012) · Hepatology · doi:10.1002/hep.25816 · Cited by 22
Engagement of CD47 Inhibits the Contact Hypersensitivity Response Via the Suppression of Motility and B7 Expression by Langerhans Cells
Yu, X., Fukunaga, A., Nagai, H., Oniki, S., Honma, N., Ichihashi, M., Matozaki, T., Nishigori, C., & Horikawa, T. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700176 · Cited by 20
CD47 Deficiency Does Not Impede Polymorphonuclear Neutrophil Transmigration but Attenuates Granulopoiesis at the Postacute Stage of Colitis
Bian, Z., Guo, Y.-L., Luo, Y., Tremblay, A., Zhang, X., Dharma, S. S., Mishra, A., & Liu, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201963 · Cited by 19
Essential roles of SHPS-1 in induction of contact hypersensitivity of skin
Motegi, S., Okazawa, H., Murata, Y., Kanazawa, Y., Saito, Y., Kobayashi, H., Ohnishi, H., Oldenborg, P., Ishikawa, O., & Matozaki, T. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.08.005 · Cited by 18
Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells
Irandoust, M. I., Zárate, J. Á., Hubeek, I., van Beek, E. M., Schornagel, K., Broekhuizen, A. J. F., Akyuz, M., van de Loosdrecht, A. A., Delwel, R., Valk, P. J. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052143 · Cited by 18
Targeting SIRP‐α protects from type 2‐driven allergic airway inflammation
Raymond, M., Van, V. Q., Rubio, M., Welzenbach, K., & Sarfati, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040797 · Cited by 17
Expression of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 in Pancreatic β-Cells and Its Role in Promotion of Insulin Secretion and Protection against Diabetes
Kobayashi, M., Ohnishi, H., Okazawa, H., Murata, Y., Hayashi, Y., Kobayashi, H., Kitamura, T., & Matozaki, T. (2008) · Endocrinology · doi:10.1210/en.2008-0236 · Cited by 17
CD47 is expressed at normal levels in patients with autoimmune haemolytic anaemia and/or immune thrombocytopenia
Ahrens, N., Pagenkopf, C., Kiesewetter, H., & Salama, A. (2006) · Transfusion Medicine · doi:10.1111/j.1365-3148.2006.00688.x · Cited by 17
Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment
Nettleship, J. E., Ren, J., Scott, D. J., Rahman, N., Hatherley, D., Zhao, Y., Stuart, D. I., Barclay, A. N., & Owens, R. J. (2013) · BMC Structural Biology · doi:10.1186/1472-6807-13-13 · Cited by 14
Self-citation
Involvement of Signal Regulatory Protein α, a Negative Regulator of Toll-Like Receptor Signaling, in Impairing the MyD88-Independent Pathway and Intracellular Killing of Burkholderia pseudomallei-Infected Mouse Macrophages
Baral, P., & Utaisincharoen, P. (2012) · Infection and Immunity · doi:10.1128/iai.00718-12 · Cited by 14
Increased Susceptibility to Salmonella Infection in Signal Regulatory Protein α-Deficient Mice
Li, L., Atif, S. M., Schmiel, S. E., Lee, S., & McSorley, S. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200429 · Cited by 12
Survival and function of CD47‐deficient thymic grafts in mice
Wang, Y., Wang, H., Wang, S., Fu, Y., & Yang, Y. (2010) · Xenotransplantation · doi:10.1111/j.1399-3089.2010.00578.x · Cited by 11
Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Reduces the Severity of Collagen-Induced Arthritis
Tanaka, K., Horikawa, T., Suzuki, S., Kitaura, K., Watanabe, J. A., Gotoh, A., Shiobara, N., Itoh, T., Yamane, S., Suzuki, R., et al. (2008) · The Journal of Rheumatology · doi:10.3899/jrheum.080369 · Cited by 9
Requirement of SIRPα for protective immunity against Leishmania major
Morimoto, N., Murata, Y., Motegi, S., Suzue, K., Saito, Y., Okazawa, H., Ohnishi, H., Kotani, T., Kusakari, S., Ishikawa, O., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.062 · Cited by 5
Lymphoma spread? Target CD47-SIRPα!
Spaargaren, M. (2011) · Blood · doi:10.1182/blood-2011-09-375139 · Cited by 5

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Authors: Barclay, A. N., & van den Berg, T. K.
Affiliations: University of Oxford (GB)
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands;
ORCID: Barclay, A. Neil
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2014-03-21
Volume: 32
Issue: 1
Pages: 25-50
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032713-120142
OpenAlex: W2139418176
Cited by: 841
References: 155
Citations by year: 2026: 63 · 2025: 107 · 2024: 108 · 2023: 84 · 2022: 77 · 2021: 89 · 2020: 89 · 2019: 51 · 2018: 44 · 2017: 60 · 2016: 32 · 2015: 26 · 2014: 11
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: CD47, SIRPα, don't eat me signal, phagocytosis, immune evasion, autoimmunity, host defense, cancer immunotherapy, inflammation, xenotransplantation, graft survival, receptor evolution
MeSH terms: Animals, Antigens, Differentiation, Autoimmune Diseases, Dendritic Cells, Multigene Family, Hematologic Diseases, Humans, Neoplasms, Phagocytosis, Protein Binding, Receptors, Immunologic, T-Lymphocytes, Signal Transduction, CD47 Antigen, Immunological Synapses, Molecular Targeted Therapy

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The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

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