Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47
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Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.
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Increased CD47 levels on malignant cells correlate with dismal prognosis in AML, esophageal carcinoma, and ovarian cancer.
“increased CD47 levels on the surface of malignant cells correlate with dismal prognosis in subjects with AML, esophageal carcinoma, and ovarian cancer [888–891].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [890]
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- Authors
- Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., Majeti, R., & Weissman, I. L.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Massachusetts General Hospital (US)
- Stanford Medicine (US)
- Stanford University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Chao, Mark P.
- Majeti, Ravindra
- Weissman, Irving L.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-12-22
- Volume
- 2
- Issue
- 63
- Pages
- 63ra94-63ra94
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4126904
- OpenAlex
- W2142541925
- Cited by
- 776
- References
- 55
- Citations by year
- 2026: 35 · 2025: 51 · 2024: 62 · 2023: 81 · 2022: 76 · 2021: 72 · 2020: 62 · 2019: 54 · 2018: 40 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 31 · 2013: 28 · 2012: 36
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (U54CA149145, CA09302, P01CA139490, R01CA086017, T32CA009302)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- calreticulin, CD47, anti-CD47 antibody, low density lipoprotein receptor-related protein, tumor immune evasion, prognostic factors, acute myeloid leukemia, non-Hodgkin lymphoma, bladder cancer, neuroblastoma, innate immunity
- MeSH terms
- Animals, Urinary Bladder Neoplasms, Cell Line, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Phagocytosis, Leukemia, Myeloid, Acute, Calreticulin, Cell Line, Tumor, Mice, CD47 Antigen, In Vitro Techniques
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