Cited by 779Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Chao, Mark P., Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A., Gentles, Andrew J., Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B. +4 more·2010·Science Translational Medicine

Abstract

Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.

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Authors
Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., Majeti, R., & Weissman, I. L.
Affiliations
  • Institute for Stem Cell Biology and Regenerative Medicine (US)
  • Massachusetts General Hospital (US)
  • Stanford Medicine (US)
  • Stanford University (US)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
  • Chao, Mark P.
  • Majeti, Ravindra
  • Weissman, Irving L.
Venue
Science Translational Medicine
Published
2010-12-22
Volume
2
Issue
63
Pages
63ra94-63ra94
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2142541925
Cited by
776
References
55
Citations by year
2026: 35 · 2025: 51 · 2024: 62 · 2023: 81 · 2022: 76 · 2021: 72 · 2020: 62 · 2019: 54 · 2018: 40 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 31 · 2013: 28 · 2012: 36
FWCI
10.73
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Cancer Institute (U54CA149145, CA09302, P01CA139490, R01CA086017, T32CA009302)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
calreticulin, CD47, anti-CD47 antibody, low density lipoprotein receptor-related protein, tumor immune evasion, prognostic factors, acute myeloid leukemia, non-Hodgkin lymphoma, bladder cancer, neuroblastoma, innate immunity
MeSH terms
Animals, Urinary Bladder Neoplasms, Cell Line, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Phagocytosis, Leukemia, Myeloid, Acute, Calreticulin, Cell Line, Tumor, Mice, CD47 Antigen, In Vitro Techniques

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