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Tissue Homeostasis and Inflammation
Open accessAbstract
There is a growing interest in understanding tissue organization, homeostasis, and inflammation. However, despite an abundance of data, the organizing principles of tissue biology remain poorly defined. Here, we present a perspective on tissue organization based on the relationships between cell types and the functions that they perform. We provide a formal definition of tissue homeostasis as a collection of circuits that regulate specific variables within the tissue environment, and we describe how the functional organization of tissues allows for the maintenance of both tissue and systemic homeostasis. This leads to a natural definition of inflammation as a response to deviations from homeostasis that cannot be reversed by homeostatic mechanisms alone. We describe how inflammatory signals act on the same cellular functions involved in normal tissue organization and homeostasis in order to coordinate emergency responses to perturbations and ultimately return the system to a homeostatic state. Finally, we consider the hierarchy of homeostatic and inflammatory circuits and the implications for the development of inflammatory diseases.
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“Immune cells and secreted factors such as cytokines are widely involved in the maintenance of tissue homeostasis.7”
From Molecular and spatial signatures of mouse brain aging at single-cell resolution (2023) · cites this paper as [7]
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Metadata
- Authors
- Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R.
- Affiliations
- Yale University (US)
- Harvard University (US)
- Boston Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Medzhitov, Ruslan
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2021-04-26
- Volume
- 39
- Issue
- 1
- Pages
- 557-581
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W3135024921
- Cited by
- 364
- References
- 158
- Citations by year
- 2026: 53 · 2025: 88 · 2024: 95 · 2023: 72 · 2022: 44 · 2021: 11
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Cancer Research Institute
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL139116, F31HL139116)
- National Institute of General Medical Sciences (T32GM136651)
- National Institute of Allergy and Infectious Diseases (R01AI144152)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- tissue homeostasis, inflammation, tissue organization, systemic homeostasis, inflammatory signaling, emergency response, inflammatory diseases, cell types
- MeSH terms
- Animals, Homeostasis, Humans, Inflammation
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