The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective
Abstract
Transcription initiation is the crucial focal point of gene expression in prokaryotes. The key players in this process, sigma factors (σs), associate with the catalytic core RNA polymerase to guide it through the essential steps of initiation: promoter recognition and opening, and synthesis of the first few nucleotides of the transcript. Here we recount the key advances in σ biology, from their discovery 45 years ago to the most recent progress in understanding their structure and function at the atomic level. Recent data provide important structural insights into the mechanisms whereby σs initiate promoter opening. We discuss both the housekeeping σs, which govern transcription of the majority of cellular genes, and the alternative σs, which direct RNA polymerase to specialized operons in response to environmental and physiological cues. The review concludes with a genome-scale view of the extracytoplasmic function σs, the most abundant group of alternative σs.
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Cites
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Self-citationCrystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution
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Self-citationThe htpR gene product of E. coli is a sigma factor for heat-shock promoters
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Self-citationConserved and Variable Functions of the σE Stress Response in Related Genomes
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Cited by
Thomason, M. K., Bischler, T., Eisenbart, S. K., Förstner, K. U., Zhang, A., Herbig, A., Nieselt, K., Sharma, C. M., & Storz, G. (2015) · Journal of Bacteriology · doi:10.1128/jb.02096-14 · Cited by 335
Liu, B., Yang, F., Huang, D.-S., & Chou, K.-C. (2018) · Bioinformatics · doi:10.1093/bioinformatics/btx579 · Cited by 331
Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180
Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology
Gale, G. A. R., Schiavon Osorio, A. A., Mills, L. A., Wang, B., Lea-Smith, D. J., & McCormick, A. J. (2019) · Microorganisms · doi:10.3390/microorganisms7100409 · Cited by 61
Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase
Fraser, A., Sokolova, M. L., Drobysheva, A. V., Gordeeva, J. V., Borukhov, S., Jumper, J., Severinov, K. V., & Leiman, P. G. (2022) · Nature Communications · doi:10.1038/s41467-022-31214-6 · Cited by 7
Metadata
- Authors
- Feklístov, A., Sharon, B. D., Darst, S. A., & Gross, C. A.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2014-09-08
- Volume
- 68
- Issue
- 1
- Pages
- 357-376
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2130512803
- Cited by
- 473
- References
- 76
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
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