The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance
Abstract
Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance. Yeasts are no exception. They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR) and in the cellular efflux of a wide variety of drugs. The PDR transporters Pdr5p of Saccharomyces cerevisiae and Cdr1p of Candida albicans are important members of this PDR subfamily, which comprises up to 10 phylogenetic clusters in fungi. Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pdr5 transports a diverse set of structurally unrelated compounds including azoles, cycloheximide, and rhodamines15.”
From Dual action antifungal small molecule modulates multidrug efflux and TOR signaling (2016) · cites this paper as [15]
Citations
Cites
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., et al. (2009) · Science · doi:10.1126/science.1168750 · Cited by 1,929
The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C., Rzhetsky, A., & Allikmets, R. L. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,820
The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C. (2001) · Genome Research · doi:10.1101/gr.gr-1649r · Cited by 1,121
Structural Biology of Rad50 ATPase
Hopfner, K., Kärcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., & Tainer, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80890-9 · Cited by 924
van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., & Gerrit van, M. E. E. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81370-7 · Cited by 854
Plant ABC proteins – a unified nomenclature and updated inventory
VERRIER, P. J., Bird, D. A., Burla, B., Dassa, E., Forestier, C., Geisler, M. M., Klein, M., Kolukisaoglu, Ü., Lee, Y., Martinoia, E., et al. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2008.02.001 · Cited by 785
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Sanglard, D., & Odds, F. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00181-0 · Cited by 784
The ABC protein turned chloride channel whose failure causes cystic fibrosis
Gadsby, D. C., Vergani, P., & Csanády, L. (2006) · Nature · doi:10.1038/nature04712 · Cited by 726
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.
Ueda, K., Okamura, N., Hirai, M., Tanigawara, Y., Saeki, T., Kioka, N., Komano, T., & Hori, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35757-0 · Cited by 672
Crystal structure of the ATP-binding subunit of an ABC transporter
Hung, L., Wang, I. X., Nikaido, K., Liu, P., Ames, G. F., & Kim, S. (1998) · Nature · doi:10.1038/25393 · Cited by 667
Research works printed but not linked: 3
- Delaveau T, 1994, PDR3, 244, 501
- Rogers B, 2001, J. Mol. Microbiol. Biotechnol., 3, 207
- Sanglard D, 1999, ASM Conf. Candida Candidiasis, 56
Cited by
Sorted by citations
Items 201–220 of 220
Upregulated pleiotropic drug resistance genes in Saccharomyces cerevisiae yrr1–52
Kodo, N., Sakata, S., & Matsuda, T. (2015) · The Nucleus · doi:10.1007/s13237-016-0156-5
Chanet, R., Kienda, G., Heneman-Masurel, A., Vernis, L., Cassinat, B., Guardiola, P., Fenaux, P., Chomienne, C., & Huang, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129222
Shekhar‐Guturja, T. (2016) · TSpace (University of Toronto)
Az antifungális rezisztencia és a virulencia összefüggésének vizsgálata Candida parapsilosis-ban
Papp, C. (2019) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.9943
", Vasilyeva, N. V., Taraskina, A. E., Bogomolova, T. S., Vybornova, I. V., Pchelin, I. M., Ryabinin, I. A., Валерьевич, А. Д., Апалько, С. В., Romaniuk, S. A., et al. (2020) · Infectious diseases News Opinions Training · doi:10.33029/2305-3496-2020-9-2-70-76
Кнорре, Д. А., Galkina, K. V., Широковских, Т. С., Банерджи, A., & Prasad, R. (2020) · Biochemistry (Moscow) · doi:10.31857/s0320972520120088
Self-citationMechanisms of pathogenesis and drug resistance in Candida auris
WeiNa, Z. H. A. O., Zhang, B., & QiMing, W. A. N. G. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0230
Candida: A Model Fungus to Study Differentiation, Pathogenesis, and Bioprospecting
Pathan, E. K., & Deshpande, M. V. (2021) · Springer eBooks · doi:10.1007/978-981-16-3307-2_13
Combinatorial approach to combat drug resistance in human pathogenic fungi
Mir, M. A., Qadri, H., Aisha, S., & Shah, A. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96127-1.00011-5
(2023) · Microbiology Australia · doi:10.1071/mav44n2
Biswas, T., Ahmed, M. A., & Mondal, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-7261-6_4
Management of Candida albicans infections by lactic acid bacteria
Vikrant, V., Sharma, A., Priyanka, P., & Azmi, W. (2023) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2023.12.2.8
The ERAD ubiquitin ligase Doa10 negatively regulates Atg32-mediated mitophagyPreprint
Eiyama, A., Onishi, M., Štupica, H., Omi, Y., Nagumo, S., Nakatsukasa, K., & Okamoto, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.08.588568
Karadzas, M. T., Michel, A. H., Mosbach, A., Giannakopoulos, G., McGettigan, R., Scalliet, G., & Kornmann, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.20.614104
Karadzas, M. T., Michel, A. H., Mosbach, A., Giannakopoulos, G., McGettigan, R., Scalliet, G., & Kornmann, B. (2025) · eLife · doi:10.7554/elife.105333
Claus, S., Jezierska, S., Elbourne, L. D. H., & Bogaert, I. V. (2022) · Figshare · doi:10.6084/m9.figshare.18093122
Bu, X., Lin, J.-Y., Cheng, J., Yang, D., Duan, C.-Q., Koffas, M. A. G., & Yan, G.-L. (2020) · Figshare · doi:10.6084/m9.figshare.13077530
Membrane Access and Orbital Localization Govern ABC Transporter Substrate Recognition
Harrizi, S., Irahal, I. N., Elbirgui, K., & Kabine, M. (2026) · Molecules · doi:10.3390/molecules31122084
Metadata
- Authors
- Prasad, R., & Goffeau, A.
- Affiliations
- Jawaharlal Nehru University (IN)
- Institut des Sciences de la Vie, Université Catholique de Louvain, Louvain-la-Neuve, 1349 Belgium;
- ORCID
- Prasad, Rajendra
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2012-10-13
- Volume
- 66
- Issue
- 1
- Pages
- 39-63
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2101491044
- Cited by
- 221
- References
- 111
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 17 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 12 · 2017: 17 · 2016: 25 · 2015: 21 · 2014: 18 · 2013: 20 · 2012: 4
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- ABC transporters, multidrug resistance, pleiotropic drug resistance, Pdr5p, Cdr1p, Saccharomyces cerevisiae, Candida albicans, drug efflux, ABC exporters
- MeSH terms
- Antifungal Agents, Candida albicans, Fungal Proteins, Humans, Saccharomyces cerevisiae, ATP-Binding Cassette Transporters, Drug Resistance, Multiple, Fungal, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
