The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Bacterial Persistence and Toxin-Antitoxin Loci
Open accessAbstract
Bacterial persistence is caused by the presence of rare, slowly growing bacteria among populations of rapidly growing cells. The slowly growing bacteria are tolerant of antibiotics and other environmental insults, whereas their isogenic, rapidly growing siblings are sensitive. Recent research has shown that persistence of the model organism Escherichia coli depends on toxin-antitoxin (TA) loci. Deletion of type II TA loci reduces the level of persistence significantly. Lon protease but no other known ATP-dependent proteases is required for persistence. Polyphosphate and (p)ppGpp also are required for persistence. These observations led to the proposal of a simple and testable model that explains the persistence of E. coli. It is now important to challenge this model and to test whether the persistence of pathogenic bacteria also depends on TA loci.
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Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB
Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009) · Science · doi:10.1126/science.1163806 · Cited by 351
Persistence: mechanisms for triggering and enhancing phenotypic variability
Balaban, N. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.10.001 · Cited by 156
Cited by
Distinguishing between resistance, tolerance and persistence to antibiotic treatment
Brauner, A., Fridman, O., Gefen, O., & Balaban, N. Q. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.34 · Cited by 1,612
ATP-Dependent Persister Formation in Escherichia coli
Shan, Y., Brown Gandt, A., Rowe, S. E., Deisinger, J. P., Conlon, B. P., & Lewis, K. (2017) · mBio · doi:10.1128/mbio.02267-16 · Cited by 508
Comparative genomics of defense systems in archaea and bacteria
Makarova, K. S., Wolf, Y. I., & Koonin, E. V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt157 · Cited by 435
A problem of persistence: still more questions than answers?
Balaban, N. Q., Gerdes, K., Lewis, K., & McKinney, J. D. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3076 · Cited by 263
Self-citationFighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics
Defraine, V., Fauvart, M., & Michiels, J. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.03.002 · Cited by 222
Metadata
- Authors
- Gerdes, K., & Maisonneuve, E.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2012-10-13
- Volume
- 66
- Issue
- 1
- Pages
- 103-123
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2023985059
- Cited by
- 387
- References
- 5
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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