The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Gut Microbiota, Inflammation, and Colorectal Cancer
Open accessAbstract
Colorectal cancer is the second-leading cause of cancer-related deaths in the United States and fourth-leading cause of cancer-related deaths worldwide. While cancer is largely considered to be a disease of genetic and environmental factors, increasing evidence has demonstrated a role for the microbiota (the microorganisms associated with the human body) in shaping inflammatory environments and promoting tumor growth and spread. Herein, we discuss both human data from meta'omics analyses and data from mechanistic studies in cell culture and animal models that support specific bacterial agents as potentiators of tumorigenesis—including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli. Further, we consider how microbes can be used in diagnosing colorectal cancer and manipulating the tumor environment to encourage better patient outcomes in response to immunotherapy treatments.
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Background
Cited by
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
The microbiome, cancer, and cancer therapy
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019) · Nature Medicine · doi:10.1038/s41591-019-0377-7 · Cited by 1,200
Meta-analysis of gut microbiome studies identifies disease-specific and shared responses
(2017) · doi:10.1038/s41467-017-01973-8 · Cited by 986
The Intestinal Microbiota in Colorectal Cancer.
Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777
Diverging inflammasome signals in tumorigenesis and potential targeting
Karki, R., & Kanneganti, T.-D. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0123-y · Cited by 641
Metadata
- Authors
- Brennan, C. A., & Garrett, W. S.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2016-09-08
- Volume
- 70
- Issue
- 1
- Pages
- 395-411
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2302902092
- Cited by
- 578
- References
- 98
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brennan, C. A., & Garrett, W. S. (2016). Gut Microbiota, Inflammation, and Colorectal Cancer. Annual Review of Microbiology. https://doi.org/10.1146/annurev-micro-102215-095513
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
