Connecting Vascular and Nervous System Development: Angiogenesis and the Blood-Brain Barrier
Abstract
The vascular and nervous systems share a common necessity of circuit formation to coordinate nutrient and information transfer, respectively. Shared developmental principles have evolved to orchestrate the formation of both the vascular and the nervous systems. This evolution is highlighted by the identification of specific guidance cues that direct both systems to their target tissues. In addition to sharing cellular and molecular signaling events during development, the vascular and nervous systems also form an intricate interface within the central nervous system called the neurovascular unit. Understanding how the neurovascular unit develops and functions, and more specifically how the blood-brain barrier within this unit is established, is of utmost importance. We explore the history, recent discoveries, and unanswered questions surrounding the relationship between the vascular and nervous systems with a focus on developmental signaling cues that guide network formation and establish the interface between these two systems.
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Brain vascular endothelial cells connect with each other through junction proteins and are enveloped by surrounding pericytes and astrocytes to form the blood-brain barrier.
“Brain vascular endothelial cells (ECs) connect with each other through junction proteins and are enveloped by surrounding pericytes and astrocytes to form the blood-brain barrier (BBB)1,2,3,4.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [3]
The blood-brain barrier restricts material exchange between the brain and blood vessels to maintain homeostasis of the brain microenvironment.
“The BBB restricts material exchange between the brain and blood vessels to maintain the homeostasis of the brain microenvironment, which is crucial for the normal development and function of the central nervous system (CNS)1,2,3,4.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [3]
Cites
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Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Xu, B., Zhang, Y., Du, X.-F., Li, J., Zi, H.-X., Bu, J.-W., Yan, Y., Han, H., & Du, J.-L. (2017) · Cell Research · doi:10.1038/cr.2017.62 · Cited by 354 · see citing works
Retinoic Acid Induces Blood–Brain Barrier Development
Mizee, M. R., Wooldrik, D., Lakeman, K. A. M., van het Hof, B., Drexhage, J. A. R., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1338-12.2013 · Cited by 203 · see citing works
Wiring the Vascular Network with Neural Cues: A CNS Perspective
Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.038 · Cited by 178 · see citing works
- Authors
- Tam, S. J., & Watts, R. J.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2010-06-01
- Volume
- 33
- Issue
- 1
- Pages
- 379-408
- ISSN
- 0147-006X
- 1545-4126
- Cited by
- 183
- References
- 7
- Language
- en
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